Effect of post-filter anticoagulation on mortality in patients with cancer-associated pulmonary embolism

  • Jieun Kang
  • Seon Ok Kim
  • Yeon-Mok Oh
  • Sang-Do Lee
  • Jae Seung Lee
Original Article
  • 4 Downloads

Abstract

Background

Malignancy is associated with an increased risk of venous thromboembolism. Inferior vena cava filters are a viable alternative when anticoagulation is infeasible because of the risk of bleeding. Although the current guidelines recommend that all patients with a vena cava filter be treated with anticoagulation treatment when the risk of bleeding is reduced, studies concerning the role of concomitant anticoagulation after vena cava filter insertion in high-risk patients are scarce. Since many cancer patients suffer from a high risk of hemorrhagic complications, we aimed to determine the effect of post-filter anticoagulation on mortality in patients with a malignant solid tumor.

Methods

A retrospective cohort study of patients with pulmonary embolism was performed between January 2010 and May 2016. Patients with a solid tumor and vena cava filter inserted because of pulmonary embolism were included. Using Cox proportional hazards model, the prognostic effect of clinical variables was analyzed.

Results

A total of 180 patients were analyzed, with 143 patients receiving and 37 patients not receiving post-filter anticoagulation treatment. Mortality was not significantly different between the two groups. The presence of metastatic cancer and that of pancreatobiliary cancer were significant risk factors for mortality. However, post-filter anticoagulation did not show significant effect on mortality regardless of the stage of cancer.

Conclusion

In patients with cancer-associated pulmonary embolism, the effect of post-filter anticoagulation on mortality may not be critical, especially in patients with a short life expectancy.

Keywords

Pulmonary embolism Venous thromboembolism Vena cava filters Anticoagulation 

Notes

Acknowledgements

This study was supported by University of Ulsan College of Medicine.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10147_2018_1290_MOESM1_ESM.docx (27 kb)
Supplementary material 1 (DOCX 27 KB)

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Copyright information

© Japan Society of Clinical Oncology 2018

Authors and Affiliations

  • Jieun Kang
    • 1
  • Seon Ok Kim
    • 2
  • Yeon-Mok Oh
    • 1
  • Sang-Do Lee
    • 1
  • Jae Seung Lee
    • 1
    • 3
  1. 1.Department of Pulmonary and Critical Care Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  2. 2.Department of Clinical Epidemiology and BiostatisticsAsan Medical CenterSeoulSouth Korea
  3. 3.Center for Pulmonary Hypertension and Venous Thrombosis, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea

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