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STAT3 rs4796793 contributes to lung cancer risk and clinical outcomes of platinum-based chemotherapy

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International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Signal transducer and activator of transcription (STAT) 3 plays a vital role in carcinogenesis and drug response. Platinum-based chemotherapy is the first-line treatment for lung cancer patients, especially those in advanced stages. In the present study, we investigated the association of STAT3 polymorphism rs4796793 with lung cancer susceptibility, platinum-based chemotherapy response, and toxicity.

Methods

A total of 498 lung cancer patients and 213 healthy controls were enrolled in the study. 467 of them received at least 2-cycle platinum-based chemotherapy. Unconditional logistical regression analysis was used to assess the associations.

Results

STAT3 rs4769793 G allele carriers had an increased susceptibility of lung cancer [additive model: adjusted OR (95% CI) 1.376 (1.058–1.789), P = 0.017; recessive model: adjusted OR (95% CI) 1.734 (1.007–2.985), P = 0.047]. Rs4769793 was not significantly associated with platinum-based chemotherapy response in lung cancer patients. STAT3 rs4796793 was associated with an increased risk of severe overall toxicity [additive model: adjusted OR (95% CI) 1.410 (1.076–1.850), P = 0.013; dominant model: adjusted OR (95% CI) 1.638 (1.091–2.459), P = 0.017], especially hematological toxicity [additive model: adjusted OR (95% CI) 1.352 (1.001–1.826), P = 0.049].

Conclusions

STAT3 rs4796793 may be considered as a potential candidate biomarker for the prediction of susceptibility and prognosis in Chinese lung cancer patients. However, well-designed studies with larger sample sizes are required to verify the results.

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Acknowledgements

The authors thank all the subjects who volunteered to take part in the study.

Funding

The work was supported by the National Key R&D Program of China (No. 2017YFC0909900) and Hubei Province health and family planning scientific research project (WJ2017M118).

Author information

Author notes

  1. Wei-Jing Gong, Li-Yun Ma and Lei Hu have contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Wei-Jing Gong, Li-Yun Ma, Yong-Ning Lv, Jia-Qiang Xu, Yong Han, Yu Zhang, Shao-Jun Shi & San-Lan Wu

  2. Department of Pharmacy, Peking University People’s Hospital, 100044, Beijing, China

    Lei Hu

  3. Wuhan Highway Management Office, Wuhan, 430000, China

    Hong Huang

  4. Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Dan-Dan Huang

  5. Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, China

    Rui-Jie Liu

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  1. Wei-Jing Gong
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Correspondence to San-Lan Wu.

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Gong, WJ., Ma, LY., Hu, L. et al. STAT3 rs4796793 contributes to lung cancer risk and clinical outcomes of platinum-based chemotherapy. Int J Clin Oncol 24, 476–484 (2019). https://doi.org/10.1007/s10147-018-01386-7

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  • DOI: https://doi.org/10.1007/s10147-018-01386-7

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