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International Journal of Clinical Oncology

, Volume 23, Issue 2, pp 314–320 | Cite as

Radiotherapy for vaginal cancer: a multi-institutional survey study of the Japanese Radiation Oncology Study Group

  • Hitoshi Ikushima
  • Masaru Wakatsuki
  • Takuro Ariga
  • Yuko Kaneyasu
  • Sunao Tokumaru
  • Fumiaki Isohashi
  • Noriko Ii
  • Takashi Uno
  • Tatsuya Ohno
  • Kokichi Arisawa
  • Takafumi Toita
Original Article

Abstract

Purpose

Our aim was to assess the patterns of practice and treatment outcomes of definitive radiotherapy (RT) for vaginal cancer in Japan.

Materials and methods

RT methods and outcomes of patients with vaginal cancer treated with definitive RT or chemoradiotherapy at 10 institutes of the Japanese Radiation Oncology Study Group between January 2000 and March 2010 were retrospectively evaluated.

Results

A total of 90 patients were enrolled in the study. The clinical stages were I, II, III, and IVA in 34, 36, 16, and 4 patients, respectively. Seventy patients were treated with three-dimensional conformal RT (3DCRT) and brachytherapy (BT), 12 with BT alone, and 8 with 3DCRT alone. Chemotherapy was administered to 29 patients. The 5-year overall survival and local control rates were 77 and 83% with a median follow-up period of 94 months for surviving or lost patients. The 5-year overall survival rates according to stage were 94, 71, 56, and 75% for stages I, II, III, and IVA, respectively. The 5-year local control rates according to stage were 94, 77, 74, and 75% for stages I, II, III, and IVA, respectively. Twenty-nine percent (6 of 21 patients) of local recurrences occurred between 5 and 10 years after RT. The 10-year local control rate of all patients was 71%. Significant prognostic factors for overall survival by univariate and multi-variate analyses were performance status, tumor size, and pelvic lymph node metastasis. Grade 3 late radiation morbidity of the rectum, pelvic bone, urinary bladder, and skin developed in 9% (8 of 90 patients).

Conclusions

Good outcomes similar to those of cervical cancer can be achieved with definitive RT delivered by 3DCRT and/or BT for vaginal cancer. Long follow-up is necessary for a continuing risk of local recurrence after 5 years.

Keywords

Brachytherapy Chemoradiotherapy Radiotherapy Vaginal cancer 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Hitoshi Ikushima
    • 1
  • Masaru Wakatsuki
    • 2
    • 3
  • Takuro Ariga
    • 4
  • Yuko Kaneyasu
    • 5
    • 6
  • Sunao Tokumaru
    • 7
    • 8
  • Fumiaki Isohashi
    • 9
  • Noriko Ii
    • 10
  • Takashi Uno
    • 11
  • Tatsuya Ohno
    • 12
  • Kokichi Arisawa
    • 13
  • Takafumi Toita
    • 4
  1. 1.Department of Therapeutic RadiologyTokushima University Graduate SchoolTokushimaJapan
  2. 2.Department of RadiologyJichi Medical UniversityShimotsukeJapan
  3. 3.National Institutes for Quantum and Radiological Science and TechnologyChibaJapan
  4. 4.Department of Radiology, Graduate School of Medical ScienceUniversity of the RyukyusNakagamiJapan
  5. 5.National Hospital Organization Fukuyama Medical CenterFukuyamaJapan
  6. 6.Department of Radiation OncologyHiroshima UniversityHigashihiroshimaJapan
  7. 7.Hyogo Ion Beam Medical CenterTatsunoJapan
  8. 8.Department of RadiologySaga UniversitySagaJapan
  9. 9.Department of Radiation OncologyOsaka University Graduate School of MedicineSuitaJapan
  10. 10.Department of Radiation OncologyMie University HospitalTsuJapan
  11. 11.Diagnostic Radiology and Radiation Oncology, Graduate School of MedicineChiba UniversityChibaJapan
  12. 12.Gunma University Heavy Ion Medical CenterMaebashiJapan
  13. 13.Department of Preventive MedicineTokushima University Graduate SchoolTokushimaJapan

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