Advertisement

International Journal of Clinical Oncology

, Volume 23, Issue 2, pp 243–248 | Cite as

Esophageal squamous cell neoplasia is an independent negative prognostic factor for head and neck cancer patients

  • Yasuhiko Hamada
  • Toshiro Mizuno
  • Kyosuke Tanaka
  • Masaki Katsurahara
  • Noriyuki Horiki
  • Reiko Yamada
  • Hiroyuki Inoue
  • Yoshiyuki Takei
  • Naoyuki Katayama
Original Article
  • 119 Downloads

Abstract

Background

Patients with head and neck cancer (HNC) have a high incidence of esophageal squamous cell neoplasms (ESCN). ESCN also has a negative impact on the survival of HNC patients. However, recent endoscopic advances enable the early detection of ESCN, and novel treatments may lead to improving survival rates for HNC patients with ESCN.

Methods

HNC patients who underwent magnifying esophagogastroduodenoscopy (EGDS) from 2005 to 2012 were included in this study (n = 226). We analyzed the prevalence and prognostic value of ESCN in HNC patients and the difference in overall survival between HNC patients with and without ESCN.

Results

Thirty-four patients (15%) developed an ESCN during their clinical course. Of the 34 patients, 10 patients underwent endoscopic resection for ESCN and 10 patients underwent simultaneous chemoradiation therapy for HNC and ESCN. The 3-year survival rates in HNC patients with and without ESCN were 53% and 70%, respectively. Multivariate analysis identified the advanced clinical stage of the HNC [hazard ratio (HR) = 2.15; 95% confidence interval (CI) = 1.18–3.93; p = 0.012] and the presence of ESCN (HR = 1.73; 95% CI = 1.00–2.97; p = 0.049) as significant and independent determinants of overall survival.

Conclusions

Our study suggests that although the survival of HNC patients with ESCN may be improved by routine EGDS during tumor surveys and by advances in endoscopy, the presence of ESCN still remains an independent negative prognostic factor for HNC patients.

Keywords

Head and neck cancer Esophageal neoplasia Prognostic factor 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Ferlay J, Soerjomataram I, Dikshit R et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386CrossRefPubMedGoogle Scholar
  2. 2.
    Chuang SC, Scelo G, Tonita JM et al (2008) Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries. Int J Cancer 123:2390–2396CrossRefPubMedGoogle Scholar
  3. 3.
    Schwartz LH, Ozsahin M, Zhang GN et al (1994) Synchronous and metachronous head and neck carcinomas. Cancer (Phila) 74:1933–1938CrossRefGoogle Scholar
  4. 4.
    Bongers V, Braakhuis BJ, Tobi H et al (1996) The relation between cancer incidence among relatives and the occurrence of multiple primary carcinomas following head and neck cancer. Cancer Epidemiol Biomark Prev 5:595–598Google Scholar
  5. 5.
    Johnson N (2001) Tobacco use and oral cancer: a global perspective. J Dent Educ 65:328–339PubMedGoogle Scholar
  6. 6.
    Slaughter DP, Southwick HW, Smejkal W (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer (Phila) 6:963–968CrossRefGoogle Scholar
  7. 7.
    Haughey BH, Gates GA, Arfken CL et al (1992) Meta-analysis of second malignant tumors in head and neck cancer: the case for an endoscopic screening protocol. Ann Otol Rhinol Laryngol 101:105–112CrossRefPubMedGoogle Scholar
  8. 8.
    Muto M, Hironaka S, Nakane M et al (2002) Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer. Gastrointest Endosc 56:517–521CrossRefPubMedGoogle Scholar
  9. 9.
    Su YY, Chen WC, Chuang HC et al (2013) Effect of routine esophageal screening in patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg 139:350–354CrossRefPubMedGoogle Scholar
  10. 10.
    Wang WL, Lee CT, Lee YC et al (2011) Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer. Head Neck 33:77–81CrossRefPubMedGoogle Scholar
  11. 11.
    Hung SH, Tsai MC, Liu TC et al (2013) Routine endoscopy for esophageal cancer is suggestive for patients with oral, oropharyngeal and hypopharyngeal cancer. PLoS One 8:e72097CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Chen MC, Huang WC, Chan CH et al (2010) Impact of second primary esophageal or lung cancer on survival of patients with head and neck cancer. Oral Oncol 46:249–254CrossRefPubMedGoogle Scholar
  13. 13.
    León X, Quer M, Diez S et al (1999) Second neoplasm in patients with head and neck cancer. Head Neck 21:204–210CrossRefPubMedGoogle Scholar
  14. 14.
    Chu PY, Chang SY, Huang JL et al (2010) Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol 31:168–174CrossRefPubMedGoogle Scholar
  15. 15.
    Sobin LH, Wittekind C (2002) TNM classification of malignant tumours, 6th edn. Wiley, HobokenGoogle Scholar
  16. 16.
    Uedo N, Fujishiro M, Goda K et al (2011) Role of narrow band imaging for diagnosis of early-stage esophagogastric cancer: current consensus of experienced endoscopists in Asia-Pacific region. Dig Endosc 23:58–71CrossRefPubMedGoogle Scholar
  17. 17.
    Lee CT, Chang CY, Lee YC et al (2010) Narrow-band imaging with magnifying endoscopy for the screening of esophageal cancer in patients with primary head and neck cancers. Endoscopy 42:613–619CrossRefPubMedGoogle Scholar
  18. 18.
    Lim H, Kim DH, Jung HY et al (2015) Clinical significance of early detection of esophageal cancer in patients with head and neck cancer. Gut Liver 9:159–165CrossRefPubMedGoogle Scholar
  19. 19.
    Cooper JS, Porter K, Mallin K et al (2009) National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck 31:748–758CrossRefPubMedGoogle Scholar
  20. 20.
    Guillot T, Spielmann M, Kac J et al (1992) Neoadjuvant chemotherapy in multiple synchronous head and neck and esophagus squamous cell carcinomas. Laryngoscope 102:311–319CrossRefPubMedGoogle Scholar
  21. 21.
    Nguyen TD, Panis X, Legros M et al (1989) Neoadjuvant chemotherapy and irradiation in multiple synchronous squamous cell carcinoma of the upper aerodigestive tract. Radiother Oncol 16:283–288CrossRefPubMedGoogle Scholar
  22. 22.
    Welz S, Schmid A, Hehr T et al (2005) Treatment-outcome for synchronous head-and-neck and oesophageal squamous cell carcinoma. Radiother Oncol 77:267–270CrossRefPubMedGoogle Scholar
  23. 23.
    Shinoto M, Shioyama Y et al (2011) Clinical results of definitive chemoradiotherapy for patients with synchronous head and neck squamous cell carcinoma and esophageal cancer. Am J Clin Oncol 34:362–366CrossRefPubMedGoogle Scholar
  24. 24.
    Schallenkamp JM, Miller RC, Brinkmann DH et al (2007) Incidence of radiation pneumonitis after thoracic irradiation: dose–volume correlates. Int J Radiat Oncol Biol Phys 67:410–416CrossRefPubMedGoogle Scholar
  25. 25.
    Vogelius IR, Bentzen SM (2012) A literature-based meta-analysis of clinical risk factors for development of radiation induced pneumonitis. Acta Oncol 51:975–983CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Yasuhiko Hamada
    • 1
  • Toshiro Mizuno
    • 2
  • Kyosuke Tanaka
    • 1
  • Masaki Katsurahara
    • 1
  • Noriyuki Horiki
    • 1
  • Reiko Yamada
    • 3
  • Hiroyuki Inoue
    • 3
  • Yoshiyuki Takei
    • 3
  • Naoyuki Katayama
    • 2
  1. 1.Department of Endoscopic MedicineMie University HospitalTsuJapan
  2. 2.Department of Hematology and OncologyMie University Graduate School of MedicineTsuJapan
  3. 3.Department of Gastroenterology and HepatologyMie University Graduate School of MedicineTsuJapan

Personalised recommendations