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International Journal of Clinical Oncology

, Volume 23, Issue 1, pp 181–188 | Cite as

Clinical outcomes of patients with epithelioid sarcomas: impact and management of nodal metastasis

  • Hidetatsu Outani
  • Yoshinori Imura
  • Takaaki Tanaka
  • Satoshi Takenaka
  • Kazuya Oshima
  • Kenichiro Hamada
  • Shigeki Kakunaga
  • Susumu Joyama
  • Norifumi Naka
  • Ikuo Kudawara
  • Takafumi Ueda
  • Nobuhito Araki
  • Hideki Yoshikawa
Original Article

Abstract

Purpose

An epithelioid sarcoma is a rare histological subtype of a soft tissue sarcoma with a high local recurrence rate, which frequently shows lymph node metastasis. However, because of the rarity of this tumor, the impact of nodal metastasis and its appropriate management remain unclear. The present study investigated the clinical outcomes of patients with epithelioid sarcomas, with a focus on lymph node metastasis.

Methods

We retrospectively evaluated the clinical outcomes of 27 patients with epithelioid sarcomas treated between 1985 and 2015. The log-rank test was used to assess the prognostic variables.

Results

The overall local recurrence rate was 33%, and the estimated overall 5-year survival rate was 62%. Hand and foot locations were associated with favorable overall survival. During the follow-up period, new nodal metastasis was noted in 14 patients (52%). The incidence of local recurrence was higher in patients with new nodal metastasis than in patients who did not develop nodal metastasis. The development of new nodal metastasis had a tendency to worsen survival; however, this association was not statistically significant. Lymphadenectomy did not affect overall survival.

Conclusions

Peripheral tumor location is associated with a better prognosis. The development of new nodal metastasis tends to be associated with poor prognosis; however, among patients with nodal metastasis, resection of the metastatic lesions has a low impact on survival.

Keywords

Epithelioid sarcoma Clinical outcome Lymph node metastasis Prognosis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

There is no funding source.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Hidetatsu Outani
    • 1
    • 2
  • Yoshinori Imura
    • 1
  • Takaaki Tanaka
    • 1
  • Satoshi Takenaka
    • 2
  • Kazuya Oshima
    • 1
  • Kenichiro Hamada
    • 2
  • Shigeki Kakunaga
    • 3
  • Susumu Joyama
    • 4
  • Norifumi Naka
    • 1
  • Ikuo Kudawara
    • 3
  • Takafumi Ueda
    • 3
  • Nobuhito Araki
    • 1
  • Hideki Yoshikawa
    • 2
  1. 1.Musculoskeletal Oncology ServiceOsaka International Cancer InstituteChuou-kuJapan
  2. 2.Department of Orthopaedic SurgeryOsaka University Graduate School of MedicineSuitaJapan
  3. 3.Department of Orthopaedic SurgeryOsaka National HospitalChuo-kuJapan
  4. 4.Department of Orthopaedic SurgeryKawachi General HospitalHigashiosakaJapan

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