International Journal of Clinical Oncology

, Volume 22, Issue 5, pp 857–864 | Cite as

Post-recurrence chemotherapy for mesothelioma patients undergoing extrapleural pneumonectomy

  • Teruhisa TakuwaEmail author
  • Masaki Hashimoto
  • Seiji Matsumoto
  • Nobuyuki Kondo
  • Kozo Kuribayash
  • Takashi Nakano
  • Seiki Hasegawa
Original Article



Additional chemotherapy is often not feasible in patients with recurrent malignant pleural mesothelioma (MPM) undergoing extrapleural pneumonectomy (EPP), due to deteriorated cardiopulmonary reserve. We thus examined the feasibility and efficacy of additional chemotherapy in patients with recurrent MPM after EPP.


A retrospective review was conducted of 59 consecutive patients who underwent bi-/tri-modal treatment with induction chemotherapy, EPP, and radiation therapy from July 2004 to August 2013 at Hyogo College of Medicine (Nishinomiya, Japan).


Of 59 patients, 39 (male/female = 31/8, right/left = 15/24, pathological stage I/II/III/IV = 1/7/23/3, bi-/tri-modality = 27/12) relapsed at a median age of 62 (range 37–71) years. The median time to recurrence after EPP was 11.6 months. Of the 39 relapsed patients, 12 received best supportive care alone, six started but discontinued chemotherapy, and the remaining 21 (53%) completed more than three cycles of intravenous chemotherapy. The median survival time after EPP was significantly longer in 21 patients who received additional chemotherapy than in 18 patients who did not (39.2 vs. 12.2 months, P = 0.009).


Additional systemic chemotherapy was successfully administered in more than 50% of relapsed patients after bi-/tri-modal treatment, which included EPP, and resulted in a longer survival in comparison with best supportive care alone.


Extrapleural pneumonectomy Malignant pleural mesothelioma Post-recurrence chemotherapy Radiation therapy Best supportive care 



The authors would like to thank Enago ( for the English language review.

Compliance with ethical standards


None declared.

Conflict of interest

All authors have declared no conflicts of interest.


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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Teruhisa Takuwa
    • 1
    Email author
  • Masaki Hashimoto
    • 1
  • Seiji Matsumoto
    • 1
  • Nobuyuki Kondo
    • 1
  • Kozo Kuribayash
    • 2
  • Takashi Nakano
    • 2
  • Seiki Hasegawa
    • 1
  1. 1.Department of Thoracic SurgeryHyogo College of MedicineNishinomiyaJapan
  2. 2.Department of Respiratory MedicineHyogo College of MedicineNishinomiyaJapan

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