International Journal of Clinical Oncology

, Volume 22, Issue 2, pp 269–273

Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population

  • Yoshitaka Nishikawa
  • Masashi Kanai
  • Maiko Narahara
  • Akiko Tamon
  • J. B. Brown
  • Kei Taneishi
  • Masahiko Nakatsui
  • Kazuya Okamoto
  • Yu Uneno
  • Daisuke Yamaguchi
  • Teruko Tomono
  • Yukiko Mori
  • Shigemi Matsumoto
  • Yasushi Okuno
  • Manabu Muto
Original Article

DOI: 10.1007/s10147-016-1061-2

Cite this article as:
Nishikawa, Y., Kanai, M., Narahara, M. et al. Int J Clin Oncol (2017) 22: 269. doi:10.1007/s10147-016-1061-2

Abstract

Background

Lung cancer is the leading cause of cancer death and is closely linked to tobacco smoking. Genetic polymorphisms in genes that encode enzymes involved in metabolizing tobacco carcinogens could affect an individual’s risk for lung cancer. While polymorphism of UDP-glucuronosyltransferase1A1 (UGT1A1) is involved in detoxification of benzo(a)pyrene-7,8-dihydrodiol(–), a major tobacco carcinogen, the association between UGT1A1 genotype and lung cancer has not been examined.

Methods

We retrieved the clinical data of 5,285 patients who underwent systemic chemotherapy at Kyoto University Hospital. A total of 765 patients (194 lung cancer patients and 671 patients with other malignancies) with UGT1A1 genotyping data were included in this analysis. We used logistic regression with recessive, dominant, and additive models to identify differences in genotype frequencies between lung cancer and other malignancies.

Results

In the recessive model, UGT1A1*28*28 genotype was significantly associated with lung cancer compared to other malignancies (odds ratio 5.3, P = 0.0083). Among lung cancer patients with a smoking history, squamous cell carcinoma was significantly predominant in patients with UGT1A1*28*28 compared to those with other UGT1A1 genotypes (P = 0.024).

Conclusion

This is the first study to demonstrate a significant association between the homozygous UGT1A1*28 genotype and lung cancer.

Keywords

Lung cancer Smoking UGT1A1 

Funding information

Funder NameGrant NumberFunding Note
Japan Agency for Medical Research and Development

    Copyright information

    © Japan Society of Clinical Oncology 2016

    Authors and Affiliations

    • Yoshitaka Nishikawa
      • 1
    • Masashi Kanai
      • 1
      • 2
    • Maiko Narahara
      • 3
      • 4
    • Akiko Tamon
      • 5
    • J. B. Brown
      • 5
      • 6
    • Kei Taneishi
      • 5
      • 7
    • Masahiko Nakatsui
      • 5
    • Kazuya Okamoto
      • 8
    • Yu Uneno
      • 1
    • Daisuke Yamaguchi
      • 1
    • Teruko Tomono
      • 9
    • Yukiko Mori
      • 1
      • 2
    • Shigemi Matsumoto
      • 1
    • Yasushi Okuno
      • 5
      • 7
    • Manabu Muto
      • 1
    1. 1.Department of Therapeutic Oncology, Graduate School of MedicineKyoto UniversityKyotoJapan
    2. 2.Department of Clinical Oncology, Pharmacogenomics, and Palliative Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan
    3. 3.Center for Genomic Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan
    4. 4.Department of Human GeneticsMcGill UniversityMontréalCanada
    5. 5.Department of Clinical System Onco-Informatics, Graduate School of MedicineKyoto UniversityKyotoJapan
    6. 6.Center for Medical EducationGraduate School of Medicine, Kyoto UniversityKyotoJapan
    7. 7.RIKEN Advanced Institute for Computational ScienceKobeJapan
    8. 8.Division of Medical Information Technology and Administration PlanningKyoto University HospitalKyotoJapan
    9. 9.Department of Gastroenterology and Hepatology, Graduate School of MedicineKyoto UniversityKyotoJapan

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