Japan Society of Gynecologic Oncology guidelines 2013 for the treatment of uterine body neoplasms
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The third version of the Japan Society of Gynecologic Oncology guidelines for the treatment of uterine body neoplasms was published in 2013. The guidelines comprise nine chapters and nine algorithms. Each chapter includes a clinical question, recommendations, background, objectives, explanations, and references. This revision was intended to collect up-to-date international evidence. The highlights of this revision are to (1) newly specify costs and conflicts of interest; (2) describe the clinical significance of pelvic lymph node dissection and para-aortic lymphadenectomy, including variant histologic types; (3) describe more clearly the indications for laparoscopic surgery as the standard treatment; (4) provide guidelines for post-treatment hormone replacement therapy; (5) clearly differentiate treatment of advanced or recurrent cancer between the initial treatment and the treatment carried out after the primary operation; (6) collectively describe fertility-sparing therapy for both atypical endometrial hyperplasia and endometrioid adenocarcinoma (corresponding to G1) and newly describe relapse therapy after fertility-preserving treatment; and (7) newly describe the treatment of trophoblastic disease. Overall, the objective of these guidelines is to clearly delineate the standard of care for uterine body neoplasms in Japan with the goal of ensuring a high standard of care for all Japanese women diagnosed with uterine body neoplasms.
KeywordsClinical practice guidelines Endometrial cancer Treatment Trophoblastic disease Uterine sarcoma
We thank the Japan Society of Obstetrics and Gynecology, the Japan Association of Obstetricians and Gynecologists, the Japanese Gynecologic Oncology Group, the Japan Society of Clinical Oncology, and the Japanese Society for Therapeutic Radiology and Oncology for their comments and contributions throughout the project. We also acknowledge the support by grants from the Ministry of Health, Labour and Welfare and H24-Clinical Cancer Research-001 (chief researcher, Koichi Hirata).
Members of guidelines formulation committee Yasuhiko Ebina, Hisaya Fujiwara, Shinji Fukunaga, Yasuyuki Hasuo, Atsushi Hongo, Kazuhiko Ino, Yuko Kaneyasu, Hidenori Kato, Naoki Kawamura, Yoichi Kobayashi, Kaneyuki Kubushiro, Masataka Kudo, Hideo Matsui, Koji Matsumoto, Yoshiki Mikami, Toshinari Muramatsu, Shoji Nagao, Satoru Nagase, Takafumi Nakamura, Toru Nakanishi, Satoru Nakayama, Hideyuki Ohtake, Yoshikazu Ozaki, Nobuyuki Susumu, Tsutomu Tabata, Kiyoshi Takamatsu, Masashi Takano, Satoshi Takeuchi, Yoshito Terai, Takafumi Toita, Akiko Tozawa, Takashi Uno, Hidemichi Watari, Tetsuro Yahata, Hideko Yamamoto, Koji Yamazawa, Nozomu Yanaihara, Masami Yasuda, Yoshihito Yokoyama.
Members of guidelines evaluation committee Daisuke Aoki, Yoichi Aoki, Makoto Emoto, Takayuki Enomoto, Toru Hachisuga, Seiryu Kamoi, Takahiro Kasamatsu, Noriyuki Katsumata, Junzo Kigawa, Hiroaki Kobayashi, Takeshi Kodaira, Junichi Kodama, Shinichi Komiyama, Hiroyuki Kuramoto, Makoto Kuroda, Masaki Mandai, Etsuko Miyagi, Takashi Nakano, Kaei Nasu, Fumitaka Numa, Kazunori Ochiai, Tsuyoshi Saito, Toshiaki Saito, Masaru Sakamoto, Noriaki Sakuragi, Nobuhiro Takeshima, Toshimitsu Toya, Satoshi Umezawa, Yoh Watanabe, Hiroyuki Yanai.
Compliance with ethical standards
Conflict of interest
Kiyoshi Takamatsu received lecture fees from Bayer Yakuhin, Ldt, and Pfizer Japan Inc.
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