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Predictive markers, including total lesion glycolysis, for the response of lymph node(s) metastasis from head and neck squamous cell carcinoma treated by chemoradiotherapy

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Abstract

Background

Chemoradiotherapy (CRT) is used to treat cervical lymph node(s) metastatic head and neck cancer patients. Evaluation and treatment of lymph node(s) after CRT is important to improve the prognosis.

Methods

Prior to CRT, we determined the TNM stage by visual and imaging examinations. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated from the results of fluorodeoxyglucose-positron emission tomography (FDG-PET). After CRT, the patients were divided in two groups—complete response (CR) and non-CR—and their responses were compared with the clinical characteristics.

Results

T4, N2b, N2c and TLG2.5 ≥18.8 were statistically significant predictive indices before CRT. The odds ratio, 95 % confidence interval and p value were, respectively—T4: 2.73, 1.15–6.51, 0.0230; N2b: 6.96, 1.50–32.3, 0.0132; N2c: 11.80, 2.37–58.50, 0.00258; and TLG2.5 ≥18.8: 6.25, 2.17–18.00, 0.000672.

Conclusions

TLG was found to be a good predictive factor for metastatic lymph node(s) prior to CRT treatment. After CRT treatment, FDG-PET was found to be highly specific and useful for negative screening.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Goshi Nishimura, Masanori Komatsu, Kenichiro Yabuki, Takahide Taguchi, Masahiro Takahashi, Osamu Shiono, Daisuke Sano, Yasuhiro Arai, Hideaki Takahashi, Yoshihiro Chiba & Nobuhiko Oridate

  2. Department of Radiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Masaharu Hata

Authors
  1. Goshi Nishimura
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  2. Masanori Komatsu
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  4. Kenichiro Yabuki
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Correspondence to Goshi Nishimura.

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Nishimura, G., Komatsu, M., Hata, M. et al. Predictive markers, including total lesion glycolysis, for the response of lymph node(s) metastasis from head and neck squamous cell carcinoma treated by chemoradiotherapy. Int J Clin Oncol 21, 224–230 (2016). https://doi.org/10.1007/s10147-015-0890-8

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  • DOI: https://doi.org/10.1007/s10147-015-0890-8

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