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Comparison of prognosis between patients with renal cell carcinoma on hemodialysis and those with renal cell carcinoma in the general population

International Journal of Clinical Oncology volume 20, pages 1035–1041 (2015)Cite this article

Abstract

Objective

We compared the clinical features and prognosis of renal cell carcinoma (RCC) between patients on hemodialysis (RCC-HD) and those in the general population (RCC-general).

Methods

We included a total of 1,794 patients who underwent surgery (RCC-HD, 408; RCC-general, 1,386) and analyzed the clinical characteristics and oncological outcomes using a stage-for-stage analysis between the two groups.

Results

In the RCC-HD group, the mean duration of dialysis before surgery was 120 months. Compared to the RCC-general group, the RCC-HD group tended to be younger (55 vs. 60 years, p < 0.0001) and more predominately male (84 % vs. 70 %, p < 0.0001), and the tumor size was smaller in this group (39 vs. 49 mm, p < 0.0001). The pathological characteristics of the RCC-HD group included a higher frequency of papillary tumors (22 % vs. 5 %, p < 0.0001) and stage I tumors (82 % vs. 68 %, p < 0.0001). During the follow-up period, 39 of patients (10 %) in the RCC-HD group and 193 patients (14 %) in the RCC-general group died of cancer. The patients on hemodialysis had better cancer-specific survival (CSS) than their counterparts (p = 0.0292) in the univariable analysis, but no significance was found in the multivariable analysis. In the stage-for-stage analysis, the 5-year CSS was similar between the two groups for each stage.

Conclusions

CSS appeared to be better in the RCC-HD group than in the RCC-general group, which may be associated with the higher incidence of stage I disease in the RCC-HD group. The comparable CSS between the groups in the stage-for-stage analysis supports this finding.

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Abbreviations

RCC:

Renal cell carcinoma

ESRD:

End-stage renal disease

HD:

Hemodialysis

CSS:

Cancer-specific survival

ACDK:

Acquired cystic disease of kidney

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Yasunobu Hashimoto, Toshio Takagi, Tsunenori Kondo, Junpei Iizuka, Hirohito Kobayashi, Kenji Omae, Kazuhiko Yoshida & Kazunari Tanabe

Authors
  1. Yasunobu Hashimoto
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  2. Toshio Takagi
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  3. Tsunenori Kondo
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  4. Junpei Iizuka
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  5. Hirohito Kobayashi
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  6. Kenji Omae
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  7. Kazuhiko Yoshida
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  8. Kazunari Tanabe
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Corresponding author

Correspondence to Toshio Takagi.

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Hashimoto, Y., Takagi, T., Kondo, T. et al. Comparison of prognosis between patients with renal cell carcinoma on hemodialysis and those with renal cell carcinoma in the general population. Int J Clin Oncol 20, 1035–1041 (2015). https://doi.org/10.1007/s10147-015-0812-9

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  • DOI: https://doi.org/10.1007/s10147-015-0812-9

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