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International Journal of Clinical Oncology

, Volume 20, Issue 2, pp 308–316 | Cite as

[18F]fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in advanced oral squamous cell carcinoma

  • Hiroyuki ShimomuraEmail author
  • Tomonori Sasahira
  • Yasutsugu Yamanaka
  • Miyako Kurihara
  • Yuichiro Imai
  • Shigehiro Tamaki
  • Nobuhiro Yamakawa
  • Norihisa Shirone
  • Masatoshi Hasegawa
  • Hiroki Kuniyasu
  • Tadaaki Kirita
Original Article

Abstract

Background

[18F]fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) is widely used to evaluate tumor metabolic activity. The aim of this study was to evaluate the usefulness of FDG-PET in assessing the histopathological response to preoperative concurrent chemoradiotherapy (CRT) in patients with oral squamous cell carcinoma (OSCC).

Methods

Forty-five patients with resectable advanced OSCC who had received preoperative CRT followed by tumor ablative surgery between January 2004 and December 2011 were included in the study. All patients underwent FDG-PET before and after preoperative CRT. The maximum standardized uptake value (SUVmax) before (pre-SUV) and after preoperative CRT (post-SUV) and the SUVmax reduction rate (ΔSUV %) were used to evaluate the response to preoperative CRT. Correlations among SUVmax, histopathological response, and expression of cancer antigen Ki-67 and hypoxia-inducible factor-1α (HIF-1α) were analyzed.

Results

Preoperative CRT significantly reduced intratumoral FDG uptake (P < 0.001). The pre-SUV and post-SUV were significantly lower in patients with a pathological complete response (pCR) than in those with a non-pCR (pre-SUV P = 0.037; post-SUV P = 0.001). ΔSUV % was higher in patients with pCR than in those with non-pCR (P = 0.029). The pre-SUV was significantly correlated with Ki-67 and HIF-1α expression in pretreatment biopsy specimens (Ki-67 P = 0.046, R = 0.292; HIF-1α P = 0.007, R = 0.385). The expression of both Ki-67 and HIF-1α was significantly lower in patients with pCR than in those with non-pCR (Ki-67 P < 0.001; HIF-1α P < 0.001).

Conclusions

Low pre-SUV and post-SUV and high ΔSUV % may predict a good histopathological response to preoperative CRT. Ki-67 and HIF-1α expression in pretreatment biopsy specimens were predictors of histopathological response to preoperative CRT.

Keywords

Oral squamous cell carcinoma FDG-PET Standardized uptake value Ki-67 HIF-1α Chemoradiotherapy 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2014

Authors and Affiliations

  • Hiroyuki Shimomura
    • 1
    Email author
  • Tomonori Sasahira
    • 2
  • Yasutsugu Yamanaka
    • 3
  • Miyako Kurihara
    • 2
  • Yuichiro Imai
    • 1
  • Shigehiro Tamaki
    • 3
  • Nobuhiro Yamakawa
    • 1
  • Norihisa Shirone
    • 4
  • Masatoshi Hasegawa
    • 5
  • Hiroki Kuniyasu
    • 2
  • Tadaaki Kirita
    • 1
  1. 1.Department of Oral and Maxillofacial SurgeryNara Medical UniversityKashiharaJapan
  2. 2.Department of Molecular PathologyNara Medical UniversityKashiharaJapan
  3. 3.Department of Dentistry and Oral SurgeryTakai HospitalTenriJapan
  4. 4.Department of RadiologyTakai HospitalTenriJapan
  5. 5.Department of Radiation OncologyNara Medical UniversityKashiharaJapan

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