Abstract
Background
Patients with unresectable pancreatic and biliary cancers sometimes need decompression due to obstruction of the gastrointestinal tract and/or biliary tract. The aim of this study was to determine the prognostic factors associated with an indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers.
Methods
Between April 2005 and September 2011, 37 patients with unresectable pancreatic and biliary cancers underwent palliative bypass surgery. Prognostic factors were searched for among clinical characteristics, operation-related factors, and tumor-related factors using a prospective database.
Results
The median survival time (MST) of these patients was 4.6 months, with a 6-month survival rate of 40.5 %. A multivariate Cox proportional hazards regression analysis revealed that mGPS >2 was the only independent prognostic factor for bypass surgery. Patients with an mGPS of 2 had an MST of 1.7 months, and they had a significantly worse prognosis than mGPS 0–1 patients with an MST of 6.3 months.
Conclusions
The mGPS is useful for predicting survival after surgical decompression due to gastrointestinal obstruction in patients with unresectable pancreatic and biliary cancers. Patients with a poor mGPS may not be indicated for palliative bypass surgery.
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References
Li D, Xie K, Wolff R, Abbruzzese JL et al (2004) Pancreatic cancer. Lancet 363:1049–1057
Sahani DV, Shah ZK, Catalano OA et al (2008) Radiology of pancreatic adenocarcinoma: current status of imaging. J Gastroenterol Hepatol 23:23–33
Nagakawa T, Kayahara M, Ikeda S et al (2009) Biliary tract cancer treatment: results from the biliary tract cancer statistics registry in Japan. J Hepatobiliary Pancreat Surg 9:569–575
Nakakura EK, Warren RS (2007) Palliative care for patients with advanced pancreatic and biliary cancers. Surg Oncol 16:293–297
McMillan DC, Crozier JE, Canna K et al (2007) Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int J Color Dis 22:881–886
Kneuertz PJ, Cunningham SC, Cameron JL et al (2011) Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experience. J Gastroint Surg 15:1917–1927
Maltoni M, Caraceni A, Brunelli C, Steering Committee of the European Association for Palliative Care, et al (2005) Prognostic factors in advanced cancer patients: evidence-based clinical recommendations––a study by the steering committee of the European Association for Palliative Care. J Clin Oncol 23:6240–6248
McMillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12:223–226
Roxburgh CS, McMillan DC (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Fut Oncol 6:149–163
O’Gorman P, McMillan DC, McArdle CS (2000) Prognostic factors in advanced gastrointestinal cancer patients with weight loss. Nutr Can 37:36–40
Yamashita H, Katai H (2010) Systemic inflammatory response in gastric cancer. World J Surg 34:2399–2400
Forrest LM, McMillan DC, McArdle CS et al (2005) A prospective longitudinal study of performance status, anti-inflammation-based score (GPS) and survival in patients with inoperable non-small cell lung cancer. Br J Can 92:1834–1836
Al Murri AM, Bartlett JM, Canney PA et al (2006) Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer. Br J Can 94:227–230
Glen P, Jamieson NB, McMillan DC et al (2006) Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology 6:450–453
Ramsey S, Lamb GW, Aitchison M et al (2007) Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer. Cancer 109:205–212
Shimoda M, Katoh M, Kita J et al (2010) The Glasgow Prognostic Score is a good predictor of treatment outcome in patients with unresectable pancreatic cancer. Chemotherapy 56:501–506
Dutta S, Al-Mrabt NM, Fullarton GM et al (2011) A comparison of POSSUM and GPS models in the prediction of post-operative outcome in patients undergoing oesophago-gastric cancer resection. Ann Surg Oncol 18:2808–2817
Roxburgh CS, Salmond JM, Horgan PG et al (2009) Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer. Ann Surg 249:788–793
Lamb GW, Aitchison M, Ramsey S et al (2012) Clinical utility of the Glasgow Prognostic Score in patients undergoing curative nephrectomy for renal clear cell cancer: basis of new prognostic scoring systems. Br J Can 106:279–283
Jamieson NB, Denley SM, Logue J et al (2011) A prospective comparison of the prognostic value of tumor- and patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma. Ann Surg Oncol 18:2318–2328
Horino K, Beppu T, Kuroki H et al (2012) Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma. Int J Clin Oncol [Epub ahead of print]
Krishnan S, Rana V, Janjan NA et al (2006) Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation. Cancer 107:2589–2596
Thieblemont C, Grossoeuvre A, Houot R et al (2008) Non-Hodgkin’s lymphoma in very elderly patients over 80 years. A descriptive analysis of clinical presentation and outcome. Ann Oncol 19:774–779
Engelken FJ, Bettschart V, Rahman MQ et al (2003) Prognostic factors in the palliation of pancreatic cancer. Eur J Surg Oncol 29:368–373
Costamagna G, Pandolfi M (2004) Endoscopic stenting for biliary and pancreatic malignancies. J Clin Gastroenterol 38:59–67
Maire F, Hammel P, Ponsot P et al (2006) Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas. Am J Gastroenterol 101:735–742
Graber I, Dumas R, Filoche B et al (2007) The efficacy and safety of duodenal stenting: a prospective multicenter study. Endoscopy 39:784–787
Cheng HT, Tsou YK, Lin CH et al (2011) Endoscopic metal stents for the palliation of malignant upper gastroduodenal obstruction. Hepatogastroenterology 58:1998–2002
Jeurnink SM, van Eijck CH, Steyerberg EW et al (2007) Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review. BMC Gastroenterol 7:18
Jeurnink SM, Steyerberg EW, van Hooft JE et al (2010) Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastrointest Endosc 71:490–499
Hochwald SN, Burke EC, Jarnagin WR et al (1999) Association of preoperative biliary stenting with increased postoperative infectious complications in proximal cholangiocarcinoma. Arch Surg 134:261–266
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Ikuta, Y., Takamori, H., Sakamoto, Y. et al. The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers. Int J Clin Oncol 19, 629–633 (2014). https://doi.org/10.1007/s10147-013-0613-y
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DOI: https://doi.org/10.1007/s10147-013-0613-y