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A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder

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Abstract

Background

The differences in clinical, pathological, and biological characteristics between adenocarcinoma (AC) and squamous cell/adenosquamous carcinoma (SC/ASC) of gallbladder cancer have not been well documented. This study is to compare the clinicopathological characteristics and FGFBP1 and WISP-2 expression between AC and SC/ASC patients.

Methods

We examined FGFBP1 and WISP-2 expression in 46 SC/ASC and 80 AC samples using immunohistochemistry and analyzed their correlations with clinicopathological characteristics.

Results

SC/ASCs occur more frequently in older patients and often correspond to larger tumor masses than ACs. Positive FGFBP1 and negative WISP-2 expression were significantly associated with lymph node metastasis and invasion of SC/ASCs and ACs. In addition, positive FGFBP1 and negative WISP-2 expression were significantly associated with differentiation and TMN stage in ACs. Univariate Kaplan–Meier analysis showed that either elevated FGFBP1 (p < 0.001) or lowered WISP-2 (p < 0.001) expression was closely associated with decreased overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive FGFBP1 expression (p = 0.001) or negative WISP-2 expression (p = 0.035 for SC/ASC and p = 0.009 for AC) is an independent predictor of poor prognosis in both SC/ASC and AC patients. We also revealed that differentiation, tumor size, TNM stage, lymph node metastasis, invasion, and surgical procedure were associated with survival of both SC/ASC and AC patients.

Conclusion

Our study suggested that the overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.

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Conflict of interest

All authors declared no conflict of interest.

Author information

Authors and Affiliations

  1. Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China

    Zhulin Yang & Zhi Yang

  2. Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China

    Qiong Zou & Yuan Yuan

  3. Department of Pathology, Basic School of Medicine, Central South University, Changsha, 410011, Hunan, People’s Republic of China

    Jinghe Li

  4. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China

    Daiqiang Li

  5. Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People’s Hospital, Changsha, 410007, Hunan, People’s Republic of China

    Lufeng Liang

  6. Department of Pathology, Loudi Central Hospital, Loudi, 417011, Hunan, People’s Republic of China

    Guixiang Zeng

  7. Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, 410013, Hunan, People’s Republic of China

    Senlin Chen

Authors
  1. Zhulin Yang
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  2. Zhi Yang
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  3. Qiong Zou
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  4. Yuan Yuan
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  5. Jinghe Li
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  6. Daiqiang Li
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  7. Lufeng Liang
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  8. Guixiang Zeng
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  9. Senlin Chen
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Corresponding author

Correspondence to Zhulin Yang.

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Yang, Z., Yang, Z., Zou, Q. et al. A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Int J Clin Oncol 19, 325–335 (2014). https://doi.org/10.1007/s10147-013-0550-9

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  • DOI: https://doi.org/10.1007/s10147-013-0550-9

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