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Prognostic factors for patients in postoperative brain metastases from surgically resected non-small cell lung cancer

International Journal of Clinical Oncology volume 19, pages 50–56 (2014)Cite this article

Abstract

Background

Postoperative recurrence in non-small cell lung cancer (NSCLC) reduces the life expectancy of patients. In this retrospective study, we investigated the prognostic factors in patients with postoperative brain metastases from surgical resected non-small cell lung cancer (NSCLC).

Methods

We conducted a retrospective chart review of patients who had undergone resection for NSCLC between April 2004 and February 2009 and found 65 had experienced postoperative brain metastases by March 2010. We reviewed these patients for clinicopathological information, treatments and responses to treatment, and overall survival.

Results

The 5-year survival rate after the diagnosis of brain metastases was 15.4 %. Significantly favorable prognostic factors for patients after a diagnosis of brain metastases included female gender, adenocarcinoma, a small number (1–3) of brain metastases, no extracranial metastasis at the diagnosis of brain metastases, radiation treatment (whole-brain radiation and/or stereotactic irradiation), and local treatment [stereotactic irradiation and/or surgical operation (craniotomy)]. Furthermore, in patients with only brain metastases as the postoperative initial recurrence, the favorable positive prognostic factors included a small number (1–3) of brain metastases, adjuvant chemotherapy, chemotherapy (including adjuvant and other chemotherapy and excluding epidermal growth factor receptor–tyrosine kinase inhibitors), and local treatment.

Conclusions

Our study found that the foregoing clinical characteristics in postoperative brain metastases and the administration of treatment contributed to patient life expectancy.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Affiliations

  1. Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University Hospital, 54 Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Jin Sakamoto, Makoto Sonobe, Masashi Kobayashi, Masashi Ishikawa, Ryutaro Kikuchi, Daisuke Nakajima, Tetsu Yamada, Ei Nakayama, Tsuyoshi Takahashi, Toshihiko Sato, Fengshi Chen, Toru Bando & Hiroshi Date

Authors
  1. Jin Sakamoto
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  2. Makoto Sonobe
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  3. Masashi Kobayashi
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  4. Masashi Ishikawa
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  5. Ryutaro Kikuchi
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  6. Daisuke Nakajima
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  7. Tetsu Yamada
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  8. Ei Nakayama
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  9. Tsuyoshi Takahashi
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  10. Toshihiko Sato
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  11. Fengshi Chen
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  12. Toru Bando
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  13. Hiroshi Date
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Corresponding author

Correspondence to Hiroshi Date.

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Cite this article

Sakamoto, J., Sonobe, M., Kobayashi, M. et al. Prognostic factors for patients in postoperative brain metastases from surgically resected non-small cell lung cancer. Int J Clin Oncol 19, 50–56 (2014). https://doi.org/10.1007/s10147-012-0503-8

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  • DOI: https://doi.org/10.1007/s10147-012-0503-8

Keywords

  • Prognostic factors
  • Postoperative brain metastases
  • Non-small cell lung cancer