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The relationship between urinary bisphenol A levels and meningioma in Chinese adults

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Abstract

Background

Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.

Method

An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.

Results

A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).

Conclusion

In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant NSFC-30871386).

Conflict of interest

No author has any conflict of interest.

Author information

Author notes

  1. Bo Duan

    Present address: Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China

Authors and Affiliations

  1. Department of Neurosurgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China

    Bo Duan, Xuebin Hu & Hongyang Zhao

  2. Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China

    Jun Qin & Jie Luo

Authors
  1. Bo Duan
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  2. Xuebin Hu
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  3. Hongyang Zhao
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  4. Jun Qin
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  5. Jie Luo
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Corresponding author

Correspondence to Hongyang Zhao.

Additional information

B. Duan and X. Hu contributed equally to this work.

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Cite this article

Duan, B., Hu, X., Zhao, H. et al. The relationship between urinary bisphenol A levels and meningioma in Chinese adults. Int J Clin Oncol 18, 492–497 (2013). https://doi.org/10.1007/s10147-012-0408-6

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  • DOI: https://doi.org/10.1007/s10147-012-0408-6

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