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Frequency of fibromyalgia syndrome in breast cancer patients

International Journal of Clinical Oncology volume 18, pages 285–292 (2013)Cite this article

A Letter to the Editor to this article was published on 30 March 2013

Abstract

Background

We aimed to determine the frequency of fibromyalgia syndrome (FM) in operated breast cancer patients and to research the relationship between FM and the severity of fatigue and quality of life in these breast cancer patients.

Methods

The demographic data of 101 operated breast cancer patients were recorded. The patients who had pain were then classified as having regional pain (RP), widespread pain without FM (WP), and widespread pain with FM (WFM). The FM diagnosis was based on the American College of Rheumatology (ACR) criteria. The severity of fatigue was evaluated with the Brief Fatigue Inventory, the disease impact was evaluated with the Fibromyalgia Impact Questionnaire (FIQ), and the quality of life was evaluated with the European Organization for Research on Treatment of Cancer questionnaire Quality of Life-C30 (EORTC-QoL-C30).

Results

There was no pain in 38 (37.6%) patients, whereas there was pain in 63 (62.4%) patients (N = 42, 41.6% had RP, N = 21, 20.8% had WP). Ten (9.9%) of the entire patient cohort were diagnosed as having FM according to the ACR criteria. There were no differences among the 3 groups in respect to demographic characteristics when patients were classified as RP (N = 42), WP (N = 11), and WFM (N = 10) groups. While there were negative correlations between the FIQ and EORTC-QoL-C30-function score (r = −0.727) and EORTC-QoL-C30-global score (r = −0.488), there was a positive correlation between the FIQ and EORTC-QoL-C30-symptom score (r = 0.726).

Conclusion

We note that the frequency of FM in the operated breast cancer patients in this study was higher than that reported in normal populations in the literature. Also, we found that the presence of FM had negative effects on the quality of life of the breast cancer patients. Accordingly, in the evaluation of widespread pain and complaints of fatigue in long-surviving breast cancer patients, after metastatic disease is excluded, the probability of FM should be kept in mind, so that appropriate treatment can be initiated to improve their functional status and quality of life.

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References

  1. Burckhardt CS, Jones KD (2005) Effects of chronic widespread pain on the health status and quality of life of women after breast cancer surgery. Health Qual Life Outcomes 3:30

    Article  PubMed  Google Scholar 

  2. Peto R, Boreham J, Clarke M et al (2000) UK and USA breast cancer deaths down 25% in year 2000 at ages 20–69. Lancet 355:1822

    Article  PubMed  CAS  Google Scholar 

  3. Bardwell WA, Major JM, Rock CL et al (2004) Health-related quality of life in women previously treated for early-stage breast cancer. Psychooncology 13(9):595–604

    Article  PubMed  Google Scholar 

  4. Yates PM, Edwards HE, Nash RE et al (2002) Barriers to effective cancer pain management. A survey of hospitalized cancer patients in Australia. J Pain Symptom Manage 23:393–405

    Article  PubMed  Google Scholar 

  5. Amichetti M, Caffo O (2003) Pain after quadranectomy and radiotherapy for early-stage breast cancer: incidence, characteristics and influence on quality of life. Oncology 65:23–28

    Article  PubMed  Google Scholar 

  6. Caffo O, Amichetti M, Ferro A et al (2003) Pain and quality of life after surgery for breast cancer. Breast Cancer Res Treat 80:39–48

    Article  PubMed  Google Scholar 

  7. Fortner BV, Stepanski EJ, Wang SC et al (2002) Sleep and quality of life in breast cancer patients. J Pain Symptom Manage 24:471–480

    Article  PubMed  Google Scholar 

  8. Torres Lacomba M, Mayoral del Moral O, Coperias Zazo JL et al (2010) Incidence of myofascial pain syndrome in breast cancer surgery: a prospective study. Clin J Pain 26(4):320–325

    Article  PubMed  Google Scholar 

  9. Randal J (1998) Post-mastectomy pain found to be common: treatment options sparse, but growing. J Natl Cancer Inst 90:731–732

    Article  PubMed  CAS  Google Scholar 

  10. Stevens PE, Dibble SL, Miaskowski C (1995) Prevalence, characteristics and impact of postmastectomy pain syndrome: an investigation of women’s experiences. Pain 61:61–68

    Article  PubMed  CAS  Google Scholar 

  11. Wallace MS, Wallace AM, Lee J et al (1996) Pain after breast surgery: a survey of 282 women. Pain 66:195–205

    Article  PubMed  CAS  Google Scholar 

  12. Weir PT, Harlan GA, Nkoy FL et al (2006) The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes. J Clin Rheumatol 12(3):124–128

    Article  PubMed  Google Scholar 

  13. Staud R, Cannon RC (2003) Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia. Pain 102:87–95

    Article  PubMed  Google Scholar 

  14. Waylonis GW, Perkins RH (1994) Post-traumatic fibromyalgia: a long-term follow up. Am J Phys Med Rehabil 73:403–412

    Article  PubMed  CAS  Google Scholar 

  15. Warner E, Keshavjee al-N, Shupak R et al (1997) Rheumatic symptoms following adjuvant therapy for breast cancer. Am J Clin Oncol 20(3):322–326

    Google Scholar 

  16. Nyrén O, Yin L, Josefsson S et al (1998) Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden. BMJ 316(7129):417–422

    Article  PubMed  Google Scholar 

  17. Piller NB, Thelander A (1998) Treatment of chronic postmastectomy lymphedema with low level laser therapy: a 2.5 year followup. Lymphology 31:74–86

    PubMed  CAS  Google Scholar 

  18. Vilholm OJ, Cold S, Rasmussen L et al (2008) The postmastectomy pain syndrome: an epidemiological study on the prevalence of chronic pain after surgery for breast cancer. Br J Cancer 99(4):604–610

    Article  PubMed  CAS  Google Scholar 

  19. Eyigor S, Karapolat H, Korkmaz OK et al (2009) The frequency of fibromyalgia syndrome and quality of life in hospitalized cancer patients. Eur J Cancer Care (Engl) 18(2):195–201

    Article  CAS  Google Scholar 

  20. Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172

    Article  PubMed  CAS  Google Scholar 

  21. Mendoza TR, Wang XS, Cleeland CS et al (1999) The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer 85:1186–1196

    Article  PubMed  CAS  Google Scholar 

  22. Burckhardt CS, Clark SR, Bennett RM (1991) The Fibromyalgia Impact Questionnaire: development and validation. J Rheumatol 18:728–734

    PubMed  CAS  Google Scholar 

  23. Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-c30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376

    Article  PubMed  CAS  Google Scholar 

  24. Topbas M, Cakirbay H, Gulec H et al (2005) The prevalence of fibromyalgia in women aged 20–64 in Turkey. Scand J Rheumatol 34:140–144

    PubMed  CAS  Google Scholar 

  25. Chen ML, Chang HK (2004) Physical symptom profiles of depressed and nondepressed patients with cancer. Palliat Med 18:712–718

    Article  PubMed  Google Scholar 

  26. Herndon JE, Fleishman S, Kornblith AB et al (1999) Is quality of life predictive of the survival of patients with advanced nonsmall cell lung carcinoma? Cancer 85:333–340

    Article  PubMed  Google Scholar 

  27. Hwang SS, Chang VT, Cogswell J et al (2002) Clinical relevance of fatigue levels in cancer patients at a VA medical center. Cancer 94:2481–2489

    Article  PubMed  Google Scholar 

  28. Poole K, Fallowfield LJ (2002) The psychological impact of post-operative arm morbidity following axillary surgery for breast cancer: a critical review. Breast 11:81–87

    Article  PubMed  CAS  Google Scholar 

  29. Rietman JS, Dijkstra PU, Debreczeni R et al (2004) Impairments, disabilities and health related quality of life after treatment for breast cancer: a follow-up study 2.7 years after surgery. Disabil Rehabil 26:78–84

    Article  PubMed  Google Scholar 

  30. Henry NL, Giles JT, Ang D et al (2008) Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Breast Cancer Res Treat 111(2):365–372

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medicine Faculty, University of Pamukkale, 20070, Kinikli-Denizli, Turkey

    Nuray Akkaya, Nilgün Simsir Atalay, Hakan Alkan, Necdet Catalbas & Füsun Sahin

  2. Department of Physical Medicine and Rehabilitation, Ankara Oncology Education and Research Hospital, Ankara, Turkey

    Selin Taflan Selcuk

Authors
  1. Nuray Akkaya
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  2. Nilgün Simsir Atalay
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  3. Selin Taflan Selcuk
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  4. Hakan Alkan
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  5. Necdet Catalbas
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  6. Füsun Sahin
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Correspondence to Nuray Akkaya.

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Akkaya, N., Atalay, N.S., Selcuk, S.T. et al. Frequency of fibromyalgia syndrome in breast cancer patients. Int J Clin Oncol 18, 285–292 (2013). https://doi.org/10.1007/s10147-012-0377-9

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  • DOI: https://doi.org/10.1007/s10147-012-0377-9

Keywords

  • Breast cancer
  • Chronic pain
  • FM syndrome
  • Quality of life