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Factors associated with the survival of patients with primary small cell carcinoma of the kidney

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Abstract

Background

Primary small cell carcinoma (SCC) of the kidney is rare, and the factors associated with the survival of these patients are yet to be elucidated.

Patients and methods

We collected data on patients who were admitted to our hospital for SCC of the kidney in the last 22 years and of those in studies in the literature. Clinical characteristics were summarized using descriptive statistics. The associations of these factors with survival were evaluated using Cox regression models, and the hazard ratio of death was calculated.

Results

This study included 45 patients (8 admitted to our hospital and 37 from studies in the literature) with SCC of the kidney. The overall median survival time was 9.9 months (range 6.9–31.6). Data on demographics, clinical symptoms, tumor staging, and tumor characteristics recorded at the time of diagnosis were not associated with survival. Among the different treatment modalities applied, cisplatin-based chemotherapy afforded a strong survival advantage (hazard ratio = 0.35, p = 0.022). However, patients with early local recurrence (hazard ratio = 19.13, p = 0.012) and early distant metastasis (hazard ratio = 10.93, p = 0.003) after primary treatment showed significantly poor survival.

Conclusions

Patients with primary SCC of the kidney generally presented with large, advanced-stage tumors and showed poor survival. Early detection of the tumor, use of cisplatin-based chemotherapy, and careful follow-up for local recurrence or frequent metastasis within 6 months after the primary treatment could be important for improving overall patient survival.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan

    Shen-Yang Lee, Hsiang-Hao Hsu, Yung-Chang Chen, Cheng-Chieh Hung & Chih-Wei Yang

  2. Biostatistics Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Hui-Yi Lin

  3. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 5 Fu-Hsing Street, Gueishan, 33333, Taoyuan, Taiwan

    Yon-Cheong Wong & Li-Jen Wang

  4. Department of Pathology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan

    Kwai-Fong Ng

  5. Department of Urology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan

    Cheng-Keng Chuang

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  1. Shen-Yang Lee
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Correspondence to Li-Jen Wang.

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Lee, SY., Hsu, HH., Lin, HY. et al. Factors associated with the survival of patients with primary small cell carcinoma of the kidney. Int J Clin Oncol 18, 139–147 (2013). https://doi.org/10.1007/s10147-011-0355-7

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  • DOI: https://doi.org/10.1007/s10147-011-0355-7

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