Abstract
We report a rare case of metachronous multiple adenocarcinoma of the pancreas. A 59-year-old Japanese man visited our institute for a routine workup as a hepatitis C virus carrier, resulting in detection of a 3-cm tumor in the pancreatic body by screening echogram. Results from several imaging modalities were consistent with pancreatic carcinoma. Distal pancreatectomy along with dissection of partial gastrectomy, transverse colectomy, and lymph node dissection were performed in November 2003. Histological examination confirmed a pancreatic ductal adenocarcinoma with a clear surgical margin and negative lymph node metastases. Gemcitabine was administered for 5 years, then suspended because no recurrent signs were found. The patient returned to our hospital in March 2009, with obstructive jaundice along with a 2-cm tumor in the head of the remnant pancreas. The condition of the patient was carefully investigated and extra-pancreatic metastatic lesions were not found; a pancreaticoduodenectomy was then carried out. Histological examination revealed a diagnosis of pancreatic adenocarcinoma arising from the remnant pancreas gland.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hidalgo M (2010) Pancreatic cancer. N Engl J Med 362(17):1605–1617
Available from: http://www.jstage.jst.go.jp/article/suizo/22/1/e33/_pdf/-char/ja/
Eriguchi N, Aoyagi S, Imayama H et al (2000) Resectable carcinoma of the pancreatic head developing 7 years and 4 months after distal pancreatectomy for carcinoma of the pancreatic tail. J Hepatobiliary Pancreat Surg 7(3):316–320
Doi R, Ikeda H, Kobayashi H et al (2003) Carcinoma in the remnant pancreas after distal pancreatectomy for carcinoma. Eur J Surg Suppl (588):62–65
International Union Against Cancer (2002) TNM classification of malignant tumours. Wiley-Liss, New York
Kaplan L, Shechter FR, Rasansky HN (1953) Metachronous carcinomas of the colon. Gastroenterology 25(1):75–79
Dinis-Ribeiro M, Lomba-Viana H, Silva R et al (2002) Associated primary tumors in patients with gastric cancer. J Clin Gastroenterol 34(5):533–535
Park IJ, Yu CS, Kim HC et al (2006) Metachronous colorectal cancer. Colorectal Dis 8(4):323–327
Oettle H, Post S, Neuhaus P et al (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 297(3):267–277
Ueno H, Kosuge T, Matsuyama Y et al (2009) A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer 101(6):908–915
Conflict of interest
No author has any conflict of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Ikematsu, Y., Tamura, H., Nakata, Y. et al. Metachronous multiple adenocarcinomas of the pancreas. Int J Clin Oncol 16, 726–731 (2011). https://doi.org/10.1007/s10147-011-0206-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-011-0206-6