Abstract
A 46-year-old woman presented with whole abdominal discomfort, and imaging revealed a 3-cm-sized ill-defined ovarian mass with extensive peritoneal carcinomatosis. Histologic examination showed malignant fibrous histiocytoma of ovary with predominant myxoid stroma. Microscopic examination showed a highly cellular neoplasm composed of fibroblast-like cells with a predominant myxoid stroma and high pleomorphism and mitotic activity. Immunohistochemically, the tumor was negative for smooth muscle actin, desmin, S-100, pancytokeratin, c-kit, epithelial membrane antigen, and calretinin. Malignant fibrous histiocytoma of ovary is extremely rare, with only six previously reported cases. To the best of our knowledge, the myxoid type of malignant fibrous histiocytoma of ovary has not been previously reported in the English literature except for a case arising in a dermoid cyst of ovary. We present the case and briefly discuss the differential diagnosis.
Similar content being viewed by others
References
Coindre JM, Terrier P, Guillou L et al (2001) Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer 91:1914–1926
Daw NC, Billups CA, Pappo AS et al (2003) Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients: the St. Jude Children’s Research Hospital experience. Cancer 97:2839–2847
Kyriakos M, Kempson RL (1976) Inflammatory fibrous histiocytoma. An aggressive and lethal lesion. Cancer 37:1584–1606
O’Brien JE, Stout AP (1964) Malignant fibrous xanthomas. Cancer 17:1445–1455
Fletcher CD (1987) Malignant fibrous histiocytoma? Histopathology 11:433–437
Al-Agha OM, Igbokwe AA (2008) Malignant fibrous histiocytoma: between the past and the present. Arch Pathol Lab Med 132:1030–1035
Hanada M, Tsujimura T, Shimizu H (1981) Multiple malignancies (squamous cell carcinoma and sarcoma) arising in a dermoid cyst of the ovary. Acta Pathol Jpn 31:681–688
Mukherjee S, Sen S, Biswas P et al (2009) Primary pleomorphic sarcoma of the ovary with rhabdomyosarcomatous differentiation. Indian J Pathol Microbiol 52:217–218
Ueda G, Sato Y, Yamasaki M et al (1977) Malignant fibrous histiocytoma arising in a benign cystic teratoma of the ovary. Gynecol Oncol 5:313–322
Yamakawa Y, Fujimura M, Hidaka T et al (1999) Inflammatory malignant fibrous histiocytoma of the ovary producing interleukin-6: a case report. Gynecol Oncol 75:484–489
Dilek TU, Dilek S, Pata O et al (2006) Malignant fibrous histiocytoma of the ovary: a case report. Int J Gynecol Cancer 16 Suppl 1:352-356
Roque DM, Jones DF, Carter G et al (2010) Primary giant cell malignant fibrous histiocytoma of the ovary: case report and review of the literature. Gynecol Oncol 119:397–398
Fletcher CDM, Unni KK, Mertens F (2002) World Health Organization classification of tumors pathology and genetics of tumours of soft tissues and bone. IARC Press, Lyon
Weiss SW, Enzinger FM (1977) Myxoid variant of malignant fibrous histiocytoma. Cancer 39:1672–1685
Zagars GK, Mullen JR, Pollack A (1996) Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys 34:983–994
Conflict of interest
The authors declare no conflict of interest related to this case report.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Choi, SY., Kim, TH., Park, HS. et al. Myxoid malignant fibrous histiocytoma of the ovary: a case report. Int J Clin Oncol 16, 601–604 (2011). https://doi.org/10.1007/s10147-010-0174-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-010-0174-2