Skip to main content

Advertisement

SpringerLink
Log in

A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy

  • Case Report
  • Published:
International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Primary uterine cervical neuroendocrine tumors are rare, but affect relatively young women and the prognosis is poor despite multidisciplinary treatment. The incidence of meningeal carcinomatosis arising from malignant tumors of the uterine cervix is extremely low, only two patients with meningeal carcinomatosis arising from a uterine cervical neuroendocrine tumor have been reported in the English literature. Moreover, there have been no reports in which this was confirmed at autopsy. We encountered a pregnant woman aged 33 years who was diagnosed as having atypical carcinoid of the uterine cervix after radical surgery. Despite multidrug chemotherapy (paclitaxel + etoposide + cisplatin and irinotecan + carboplatin), the patient developed multiple organ metastases. Although there was no metastasis to the brain parenchyma or the spinal cord parenchyma, the patient also developed meningeal carcinomatosis. Whole-brain radiation therapy was performed, but was ineffective. The patient died at 19 months after her initial operation and 10 days after diagnosis of meningeal carcinomatosis. The presence of meningeal carcinomatosis was confirmed at autopsy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Viswanathan AN, Deavers MT, Jhingran A et al (2004) Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecol Oncol 93:27–33

    Article  PubMed  CAS  Google Scholar 

  2. Crowder S, Tuller E (2007) Small cell carcinoma of the female genital tract. Semin Oncol 34:57–63

    Article  PubMed  CAS  Google Scholar 

  3. Chan JK, Loizzi V, Burger RA et al (2003) Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. Cancer 97:568–574

    Article  PubMed  Google Scholar 

  4. Wang KL, Yang YC, Wang TY et al (2006) Neuroendocrine carcinoma of the uterine cervix: a clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother 18:209–216

    PubMed  Google Scholar 

  5. Lee JM, Lee KB, Nam JH et al (2008) Prognostic factors in FIGO stage IB–IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: results of a multi-center retrospective Korean study. Ann Oncol 19:321–326

    Article  PubMed  Google Scholar 

  6. Lee SW, Nam JH, Kim DY et al (2010) Unfavorable prognosis of small cell neuroendocrine carcinoma of the uterine cervix: a retrospective matched case–control study. Int J Gynecol Cancer 20:411–416

    Article  PubMed  Google Scholar 

  7. Weed JC Jr, Graff AT, Shoup B et al (2003) Small cell undifferentiated (neuroendocrine) carcinoma of the uterine cervix. J Am Coll Surg 197:44–51

    Article  PubMed  Google Scholar 

  8. Pentheroudakis G, Pavlidis N (2005) Management of leptomeningeal malignancy. Expert Opin Pharmacother 6:1115–1125

    Article  PubMed  CAS  Google Scholar 

  9. Grossman SA, Krabak MJ (1999) Leptomeningeal carcinomatosis. Cancer Treat Rev 25:103–119

    Article  PubMed  CAS  Google Scholar 

  10. Asensio N, Luis A, Costa I et al (2009) Meningeal carcinomatosis and uterine carcinoma: three different clinical settings and review of the literature. Int J Gynecol Cancer 19:168–172

    Article  PubMed  Google Scholar 

  11. Weed JC Jr, Creasman WT (1975) Meningeal carcinomatosis secondary to advanced squamous cell carcinoma of the cervix: a case report. Meningeal metastasis of advanced cervical cancer. Gynecol Oncol 3:201–204

    Article  PubMed  Google Scholar 

  12. Weithman AM, Morrison G, Ingram EA (1987) Meningeal metastasis of squamous-cell carcinoma of the uterine cervix: case report and review of the literature. Diagn Cytopathol 3:170–172

    Article  PubMed  CAS  Google Scholar 

  13. Aboulafia DM, Taylor LP, Crane RD et al (1996) Carcinomatous meningitis complicating cervical cancer: a clinicopathologic study and literature review. Gynecol Oncol 60:313–318

    Article  PubMed  CAS  Google Scholar 

  14. Rentinck ME, Schrijver HM, Kneppers E et al (2004) Carcinomatous meningitis in cancer of the uterine cervix. J Neurooncol 70:87–90

    Article  PubMed  CAS  Google Scholar 

  15. Wuntkal R, Maheshwari A, Kerkar RA et al (2004) Carcinoma of uterine cervix primarily presenting as carcinomatous meningitis: a case report. Aust N Z J Obstet Gynaecol 44:268–269

    Article  PubMed  Google Scholar 

  16. Kumar S, Nair S, Alexander M (2004) Carcinomatous meningitis occurring prior to a diagnosis of large cell neuroendocrine carcinoma of the uterine cervix. J Postgrad Med 50:311–312

    PubMed  CAS  Google Scholar 

  17. Kastritis E, Moulopoulos LA, Politi E et al (2006) Intramedullary spinal cord and leptomeningeal metastases in a patient with carcinoma of the uterine cervix. Gynecol Oncol 102:124–127

    Article  PubMed  CAS  Google Scholar 

  18. Portera CC, Gottesman RF, Srodon M et al (2006) Optic neuropathy from metastatic squamous cell carcinoma of the cervix: an unusual CNS presentation. Gynecol Oncol 102:121–123

    Article  PubMed  Google Scholar 

  19. Han L, Bhan R, Johnson S et al (2007) Leptomeningeal metastasis in a patient with squamous cell carcinoma of the uterine cervix: report of a case and review of the literature. Diagn Cytopathol 35:660–662

    Article  PubMed  Google Scholar 

  20. Ignatius RT, Wills SM, Nadeau L et al (2008) Leptomeningeal carcinomatosis due to squamous cell carcinoma of the uterine cervix associated with HPV-45. J Clin Oncol 26:154–156

    Article  PubMed  Google Scholar 

  21. Yamauchi N, Sameshima H, Osato K et al (2010) Carcinomatous meningitis from adenocarcinoma of the uterine cervix: a case report and literature review. J Obstet Gynaecol Res 36:444–447

    Article  PubMed  Google Scholar 

  22. Drappatz J, Batchelor TT (2007) Leptomeningeal neoplasms. Curr Treat Options Neurol 9:283–293

    Article  PubMed  Google Scholar 

  23. DeAngelis LM, Boutros D (2005) Leptomeningeal metastasis. Cancer Invest 23:145–154

    PubMed  Google Scholar 

  24. Gibbs AR, Thunnissen FBJM (2001) Histological typing of lung and pleural tumours: third edition. J Clin Pathol 54:498–499

    Article  PubMed  CAS  Google Scholar 

  25. Hoskins PJ, Swenerton KD, Pike JA et al (2003) Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination. J Clin Oncol 21:3495–3501

    Article  PubMed  CAS  Google Scholar 

  26. Conner MG, Richter H, Moran CA et al (2002) Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol 6:345–348

    Article  PubMed  Google Scholar 

  27. Trinh XB, Bogers JJ, Van Marck EA et al (2004) Treatment policy of neuroendocrine small cell cancer of the cervix. Eur J Gynaecol Oncol 25:40–44

    PubMed  CAS  Google Scholar 

  28. Noda K, Nishiwaki Y, Kawahara M et al (2002) Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med 346:85–91

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

No author has any conflict of interest.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan

    Shinichi Komiyama, Eiji Nishio, Yutaka Torii, Kyoko Kawamura, Shuko Oe, Rina Kato, Kiyoshi Hasagawa & Yasuhiro Udagawa

  2. Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan

    Masato Abe & Makoto Kuroda

Authors
  1. Shinichi Komiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eiji Nishio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yutaka Torii
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kyoko Kawamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shuko Oe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rina Kato
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kiyoshi Hasagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masato Abe
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Makoto Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yasuhiro Udagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shinichi Komiyama.

About this article

Cite this article

Komiyama, S., Nishio, E., Torii, Y. et al. A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy. Int J Clin Oncol 16, 581–586 (2011). https://doi.org/10.1007/s10147-010-0155-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10147-010-0155-5

Keywords

Search

Navigation