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Value of PET-FDG in primary breast cancer based on histopathological and immunohistochemical prognostic factors

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Abstract

Background

The aim of the study was to analyze in breast tumors the correlation between [18F]fluorodeoxyglucose (FDG) uptake assessed by positron emission tomography (PET) and histopathological and immunohistochemical prognostic factors.

Methods

FDG-PET combined with computed tomography (CT) was performed before surgery in 45 women with biopsy-proven primary breast cancer. The standardized uptake value (SUV) was compared with histopathological findings after surgery.

Results

A positive relationship was found between SUV and histological grade (p < 0.0001), histological type (p = 0.001), tumor size (p < 0.0435), estrogen receptor status (p < 0.0005), and progesterone receptor status (p = 0.002). FDG-PET/CT revealed unknown distant metastatic lesions in 2 of 12 patients with triple-negative breast cancer. The sensitivity of FDG-PET/CT for detecting axillary lymph node metastases was, respectively, 21% and 100% for pN1 and pN2 cases, whereas specificity was 100% for pN0.

Conclusion

SUV, a preoperative and noninvasive metabolic parameter, correlates with other known prognostic factors in breast cancer. This study provides valuable insight into the usefulness of FDG-PET/CT for preoperative staging of patients with triple-negative and poorly differentiated breast tumors but not for evaluating axillary lymph nodes and lobular carcinomas.

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Conflict of interest

No author has any conflict of interest.

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Léon Bérard Cancer Center, 28 Rue Laennec, 69008, Lyon, France

    Pierre Heudel

  2. Department of Nuclear Medicine, Léon Bérard Cancer Center, 28 Rue Laennec, 69008, Lyon, France

    Sebastien Cimarelli & Thomas Mognetti

  3. Biostatistics Unit, Léon Bérard Cancer Center, 28 Rue Laennec, 69008, Lyon, France

    Anthony Montella

  4. Department of Surgical Oncology, Léon Bérard Cancer Center, 28 Rue Laennec, 69008, Lyon, France

    Catherine Bouteille

Authors
  1. Pierre Heudel
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  2. Sebastien Cimarelli
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  3. Anthony Montella
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  4. Catherine Bouteille
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  5. Thomas Mognetti
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Corresponding author

Correspondence to Pierre Heudel.

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Heudel, P., Cimarelli, S., Montella, A. et al. Value of PET-FDG in primary breast cancer based on histopathological and immunohistochemical prognostic factors. Int J Clin Oncol 15, 588–593 (2010). https://doi.org/10.1007/s10147-010-0120-3

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  • DOI: https://doi.org/10.1007/s10147-010-0120-3

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