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Primary intracranial leiomyosarcoma in an HIV-infected patient

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Abstract

Primary intracranial leiomyosarcomas are rare tumors arising from the mesenchymal cells of the dura matter or the cerebral blood vessels. Only 14 cases of primary intracranial leiomyosarcoma are reported in the literature. We report a case of primary intracranial leiomyosarcoma in an human immunodeficiency virus-positive patient with a CD4 count of 14 cells/μL. Additionally, in-situ hybridization of Epstein–Barr virus (EBV) early RNA stained sections highlighted the tumor cells, consistent with the presence of EBV. Review of the literature strongly suggests an association between AIDS, EBV, and primary intracranial leiomyosarcoma. Given the paucity of information in the literature, we review possible chemotherapeutic agents for treatment of primary intracranial leiomyosarcoma in patients refractory to surgical resection and radiation therapy.

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References

  1. Clark MA, Fisher C, Judson I et al (2005) Soft-tissue sarcomas in adults. N Engl J Med 353:701–711

    Article  CAS  PubMed  Google Scholar 

  2. Paulus W, Slowik F, Jellinger K (1991) Primary intracranial sarcomas: histopathological features of 19 cases. Histopathology 18:395–402

    Article  CAS  PubMed  Google Scholar 

  3. Anderson WR, Cameron JD, Tsai SH (1980) Primary intracranial leiomyosarcoma. Case report with ultrastructural study. J Neurosurg 53:401–405

    Article  CAS  PubMed  Google Scholar 

  4. Asai A, Yamada H, Murata S et al (1988) Primary leiomyosarcoma of the dura mater. Case report. J Neurosurg 68:308–311

    Article  CAS  PubMed  Google Scholar 

  5. Blumenthal DT, Raizer JJ, Rosenblum MK et al (1999) Primary intracranial neoplasms in patients with HIV. Neurology 52:1648–1651

    CAS  PubMed  Google Scholar 

  6. Brown HG, Burger PC, Olivi A et al (1999) Intracranial leiomyosarcoma in a patient with AIDS. Neuroradiology 41:35–39

    Article  CAS  PubMed  Google Scholar 

  7. Citow JS, Kranzler L (2000) Multicentric intracranial smooth-muscle tumor in a woman with human immunodeficiency virus. Case report. J Neurosurg 93:701–703

    Article  CAS  PubMed  Google Scholar 

  8. Hussain S, Nanda A, Fowler M et al (2006) Primary intracranial leiomyosarcoma: report of a case and review of the literature. Sarcoma 2006:52140

    Article  PubMed  Google Scholar 

  9. Lerdlum S, Lalitanantpong S, Numkarunarunrote N et al (2004) MR imaging of CNS leiomyosarcoma in AIDS patients. J Med Assoc Thai 87(Suppl 2):S152–S160

    PubMed  Google Scholar 

  10. Litofsky NS, Pihan G, Corvi F et al (1998) Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol 40:179–183

    Article  CAS  PubMed  Google Scholar 

  11. Louis DN, Richardson EP Jr, Dickersin GR et al (1989) Primary intracranial leiomyosarcoma. Case report. J Neurosurg 71:279–282

    Article  CAS  PubMed  Google Scholar 

  12. Murakami N, Morioka T, Nishio S et al (1997) Radiation-induced leiomyosarcoma of the dura mater: a case report. No Shinkei Geka 25:1049–1053

    CAS  PubMed  Google Scholar 

  13. Niwa J, Hashi K, Minase T (1996) Radiation induced intracranial leiomyosarcoma: its histopathological features. Acta Neurochir (Wien) 138:1470–1471

    Article  CAS  Google Scholar 

  14. Skullerud K, Stenwig AE, Brandtzaeg P et al (1995) Intracranial primary leiomyosarcoma arising in a teratoma of the pineal area. Clin Neuropathol 14:245–248

    CAS  PubMed  Google Scholar 

  15. Suankratay C, Shuangshoti S, Mutirangura A et al (2005) Epstein-Barr virus infection-associated smooth-muscle tumors in patients with AIDS. Clin Infect Dis 40:1521–1528

    Article  PubMed  Google Scholar 

  16. Accessed at Center for Disease Control. http://www.cdc.gov/hiv/topics/surveillance/basic.htm#area. Accessed Nov 2009

  17. Granovsky MO, Mueller BU, Nicholson HS et al (1998) Cancer in human immunodeficiency virus-infected children: a case series from the Children’s Cancer Group and the National Cancer Institute. J Clin Oncol 16:1729–1735

    CAS  PubMed  Google Scholar 

  18. Lacy CFAL, Goldman MP, Lance LL (2008) Lexi-Comp’s drug information handbook, 17th edn. Lexi-Comp Inc, Hudson

    Google Scholar 

  19. Talbot SM, Keohan ML, Hesdorffer M et al (2003) A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. Cancer 98:1942–1946

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Tisch Cancer Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, New York, NY, 10029, USA

    Shanthi Sivendran & Myra F. Barginear

  2. Department of Pathology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, New York, NY, 10029, USA

    Claudia Irene Vidal

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  1. Shanthi Sivendran
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  2. Claudia Irene Vidal
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  3. Myra F. Barginear
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Correspondence to Shanthi Sivendran.

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Sivendran, S., Vidal, C.I. & Barginear, M.F. Primary intracranial leiomyosarcoma in an HIV-infected patient. Int J Clin Oncol 16, 63–66 (2011). https://doi.org/10.1007/s10147-010-0110-5

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  • DOI: https://doi.org/10.1007/s10147-010-0110-5

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