International Journal of Clinical Oncology

, Volume 15, Issue 3, pp 314–318 | Cite as

Ewing’s sarcoma of the kidney

  • Joel R. Angel
  • Anushayanthan Alfred
  • Ankit Sakhuja
  • Ryan E. Sells
  • Joseph John Zechlinski
Case Report

Abstract

Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing’s sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99+), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.

Keywords

Ewing’s sarcoma Primitive neuroectodermal tumor Translocation Trisomy 

References

  1. 1.
    Stout AP (1918) A tumor of the ulnar nerve. Proc NY Pathol Soc 18:2–12Google Scholar
  2. 2.
    Casella R, Moch H, Rochlitz C et al (2001) Metastatic primitive neuroectodermal tumor of the kidney in adults. Eur Urol 39:613–617CrossRefPubMedGoogle Scholar
  3. 3.
    Stiller CA, Bielack SS, Jundt G et al (2006) Bone tumours in European children and adolescents, 1978–1997. Report from the Automated Childhood Cancer Information System project. Eur J Cancer 42:2124–2135CrossRefPubMedGoogle Scholar
  4. 4.
    Chan YF, Llewellyn H (1994) Intrarenal primitive neuroectodermal tumour. Br J Urol 73:326–327CrossRefPubMedGoogle Scholar
  5. 5.
    Parham DM, Roloson GJ, Feely M et al (2001) Primary malignant neuroepithelial tumors of the kidney: a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms’ Tumor Study Group Pathology Center. Am J Surg Pathol 25:133–146CrossRefPubMedGoogle Scholar
  6. 6.
    Rodriguez-Galindo C, Marina NM, Fletcher BD et al (1997) Is primitive neuroectodermal tumor of the kidney a distinct entity? Cancer 79:2243–2250CrossRefPubMedGoogle Scholar
  7. 7.
    Seemayer TA, Thelmo WL, Bolande RP et al (1975) Peripheral neuroectodermal tumors. Perspect Pediatr Pathol 2:151–172PubMedGoogle Scholar
  8. 8.
    Glass AG, Fraumeni JF Jr (1970) Epidemiology of bone cancer in children. J Natl Cancer Inst 44:187–199PubMedGoogle Scholar
  9. 9.
    Miller RW (1981) Contrasting epidemiology of childhood osteosarcoma, Ewing’s tumor, and rhabdomyosarcoma. Natl Cancer Inst Monogr (56):9–15Google Scholar
  10. 10.
    Jimenez RE, Folpe AL, Lapham RL et al (2002) Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol 26:320–327CrossRefPubMedGoogle Scholar
  11. 11.
    Marley EF, Liapis H, Humphrey PA et al (1997) Primitive neuroectodermal tumor of the kidney—another enigma: a pathologic, immunohistochemical, and molecular diagnostic study. Am J Surg Pathol 21:354–359CrossRefPubMedGoogle Scholar
  12. 12.
    de Alava E, Gerald WL (2000) Molecular biology of the Ewing’s sarcoma/primitive neuroectodermal tumor family. J Clin Oncol 18:204–213PubMedGoogle Scholar
  13. 13.
    Turc-Carel C, Aurias A, Mugneret F et al (1988) Chromosomes in Ewing’s sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet 32:229–238CrossRefPubMedGoogle Scholar
  14. 14.
    Turc-Carel C, Philip I, Berger MP et al (1984) Chromosome study of Ewing’s sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet 12:1–19CrossRefPubMedGoogle Scholar
  15. 15.
    Zucman J, Delattre O, Desmaze C et al (1992) Cloning and characterization of the Ewing’s sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. Genes Chromosomes Cancer 5:271–277CrossRefPubMedGoogle Scholar
  16. 16.
    Gallucci M, Vico E, Sentinelli S et al (2008) Familial papillary renal carcinoma: cytogenetic characterization in normal and tumor tissues in two brothers. A case report. Urol Oncol 26:295–298PubMedGoogle Scholar
  17. 17.
    Klatte T, Rao PN, de Martino M et al (2009) Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma. J Clin Oncol 27:746–753CrossRefPubMedGoogle Scholar
  18. 18.
    Cuesta Alcala JA, Solchaga Martinez A, Caballero Martinez MC et al (2001) Primary neuroectodermal tumor (PNET) of the kidney: 26 cases. Current status of its diagnosis and treatment. Arch Esp Urol 54:1081–1093PubMedGoogle Scholar
  19. 19.
    Gupta NP, Singh BP, Raina V et al (1995) Primitive neuroectodermal kidney tumor: 2 case reports and review of the literature. J Urol 153(6):1890–1892CrossRefPubMedGoogle Scholar
  20. 20.
    Tsokos M (1992) Peripheral primitive neuroectodermal tumors. Diagnosis, classification, and prognosis. Perspect Pediatr Pathol 16:27–98PubMedGoogle Scholar
  21. 21.
    Kushner BH, Yeung HW, Larson SM et al (2001) Extending positron emission tomography scan utility to high-risk neuroblastoma: fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients. J Clin Oncol 19:3397–3405PubMedGoogle Scholar
  22. 22.
    Burgert EO Jr, Nesbit ME, Garnsey LA et al (1990) Multimodal therapy for the management of nonpelvic, localized Ewing’s sarcoma of bone: intergroup study IESS-II. J Clin Oncol 8:1514–1524PubMedGoogle Scholar
  23. 23.
    Nesbit ME Jr, Gehan EA, Burgert EO et al (1990) Multimodal therapy for the management of primary, nonmetastatic Ewing’s sarcoma of bone: a long-term follow-up of the First Intergroup Study. J Clin Oncol 8:1664–1674PubMedGoogle Scholar
  24. 24.
    Grier HE, Krailo MD, Tarbell NJ et al (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348:694–701CrossRefPubMedGoogle Scholar

Copyright information

© Japan Society of Clinical Oncology 2010

Authors and Affiliations

  • Joel R. Angel
    • 1
  • Anushayanthan Alfred
    • 1
  • Ankit Sakhuja
    • 1
  • Ryan E. Sells
    • 1
  • Joseph John Zechlinski
    • 1
  1. 1.Department of MedicineMedical College of WisconsinMilwaukeeUSA

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