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International Journal of Clinical Oncology

, Volume 14, Issue 3, pp 254–257 | Cite as

Serous adenocarcinoma of the retroperitoneum, as a type of multifocal müllerian carcinoma

  • Ayaka IuraEmail author
  • Yuko Sasajima
  • Noriyuki Katsumata
  • Takahiro Kasamatsu
Case Report

Abstract

Primary retroperitoneal serous adenocarcinoma is an extremely rare clinical entity, with only five cases previously reported. We describe a 66-year-old woman with serous adenocarcinoma arising from the retroperitoneum, adhesive to the ileocecum. On MRI, the tumor was 17 × 10 × 6 cm in size and monocystic. The tumor cells were positive for CA125, estrogen receptor, and Wilms tumor 1, and were differentiated from enterogenic cyst by the presence of cytokeratin 7 (+), and the absence of cytokeratin 20 (−). Simultaneously, uterine adnexal serous adenocarcinoma was detected. The volume of the retroperitoneal tumor was 14 times larger than that of the uterine adnexal tumor. We suggest the possibility that the retroperitoneal cancer arose as a primary cancer from rests of the müllerian epithelium synchronously with the uterine adnexal cancer. The patient had been taking conjugated estrogen for 10 years, suggesting that long-term estrogen stimulation may have contributed to the progression of the tumors.

Key words

Serous adenocarcinoma Retroperitoneum Müllerian carcinoma 

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References

  1. 1.
    Ulbright TM, Morley DJ, Roth LM, et al. (1983) Papillary serous carcinoma of the retroperitoneum. Am J Clin Pathol 79:633–637PubMedGoogle Scholar
  2. 2.
    Caruncho M, Pombo F, Arnal-Monreal F (1993) Primary retroperitoneal serous cystadenocarcinoma of “ovarian type”: US and CT findings. Eur J Radiol 17:115–116PubMedCrossRefGoogle Scholar
  3. 3.
    Kurosaki Y, Kuramoto K (1998) Case report: serous cystadenocarcinoma of the retroperitoneum: CT and sonographic appearance. Clin Radiol 53:916–918PubMedCrossRefGoogle Scholar
  4. 4.
    Fujiwara K, Oda T, Suzuki S, et al. (1999) Primary serous adenocarcinoma of the retroperitoneum with a response to platinumbased chemotherapy: a case report. Int J Gynecol Cancer 9: 170–172PubMedCrossRefGoogle Scholar
  5. 5.
    Kaku M, Ohara N, Seima Y, et al. (2004) A primary retroperitoneal serous cystadenocarcinoma with clinically aggressive behavior. Arch Gynecol Obstet 270:302–306PubMedCrossRefGoogle Scholar
  6. 6.
    Lauchlan SC (1972) The secondary müllerian system. Obstet Gynecol Surv 27:133–146PubMedCrossRefGoogle Scholar
  7. 7.
    Muto MG, Welch WR, Mok SC, et al. (1995) Evidence for a multifocal origin of papillary serous carcinoma of the peritoneum. Cancer Res 55:490–492PubMedGoogle Scholar
  8. 8.
    Halperin R, Zehavi S, Langer R, et al. (2001) Primary peritoneal serous papillary carcinoma: a new epidemiologic trend? A matched-case comparison with ovarian serous papillary cancer. Int J Gynecol Cancer 11:403–408PubMedCrossRefGoogle Scholar
  9. 9.
    Han AC, Hovenden S, Rosenblum NG, et al. (1998) Adenocarcinoma arising in extragonadal endometriosis. An immunohistochemical study. Cancer 83:1163–1169Google Scholar
  10. 10.
    Brooks JJ, Wheeler JE (1977) Malignancy arising in extragonadal endometriosis. A case report and summary of the world literature. Cancer 40:3065–3073PubMedCrossRefGoogle Scholar
  11. 11.
    Gücer F, Pieber D, Arikan G (1998) Malignancy arising in extraovarian endometriosis during estrogen stimulation. Eur J Gynaecol Oncol 19:39–41PubMedGoogle Scholar
  12. 12.
    Modesitt SC, Tortolero-Luna G, Robinson JB, et al. (2002) Ovarian and extraovarian endometriosis-associated cancer. Obstet Gynecol 100:788–795PubMedCrossRefGoogle Scholar
  13. 13.
    Jones KD, Owen E, Berresford A, et al. (2002) Case report: endometrial adenocarcinoma arising from endometriosis of the rectosigmoid colon. Gynecol Oncol 86:220–222PubMedCrossRefGoogle Scholar
  14. 14.
    Petersen VC, Underwood JC, Wells M, et al. (2002) Primary endometrioid adenocarcinoma of the large intestine arising in colorectal endometriosis. Histopathology 40:171–176PubMedCrossRefGoogle Scholar

Copyright information

© Japan Society of Clinical Oncology 2009

Authors and Affiliations

  • Ayaka Iura
    • 1
    Email author
  • Yuko Sasajima
    • 2
  • Noriyuki Katsumata
    • 1
  • Takahiro Kasamatsu
    • 3
  1. 1.Breast and Medical Oncology DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Diagnostic Pathology DivisionNational Cancer Center HospitalTokyoJapan
  3. 3.Gynecology DivisionNational Cancer Center HospitalTokyoJapan

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