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Decrease of creatinine clearance rate with aging in patients with head and neck cancer in Japan

International Journal of Clinical Oncology volume 12, pages 120–124 (2007)Cite this article

Abstract

Background

We aimed to clarify the reason for the lower dosage of cis-platinum (CDDP) in patients with head and neck cancer in Japan compared with that in other countries, by evaluating renal function.

Methods

We studied 375 patients with head and neck cancer who had been hospitalized from January 1998 to October 2005, to evaluate and treat the disease. The creatinine clearance rate (Ccr) was calculated at least three times before beginning the treatments, and the average Ccr was estimated to evaluate the renal function.

Results

The Ccr decreased with aging, and the percentages of patients with Ccr lower than 65 ml/min per 1.73 m2 were 27.1% of patients in their fifties, 36.8% in their sixties, 62.3% in their seventies, and 87.5% in their eighties. There was no correlation between renal function and the Japanese lifestyle (i.e., diet. water consumption).

Conclusion

The renal function of Japanese decreases rapidly with aging, whereas that of Americans is maintained for longer periods. The poor renal function of Japanese is one of the causes of the need to reduce the dosage of or avoid the administration of CDDP in cancer patients.

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Affiliations

  1. Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Goshi Nishimura, Choichi Horiuchi, Kenichi Satake, Takafumi Yoshida, Takahide Taguchi, Junichi Nagao, Mariko Kawakami, Norio Kondo & Yasukazu Mikami

  2. Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Mamoru Tsukuda & Hideki Matsuda

Authors
  1. Goshi Nishimura
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  2. Mamoru Tsukuda
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  3. Choichi Horiuchi
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  4. Kenichi Satake
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  5. Takafumi Yoshida
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  6. Takahide Taguchi
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  7. Junichi Nagao
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  8. Mariko Kawakami
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  9. Norio Kondo
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  10. Hideki Matsuda
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  11. Yasukazu Mikami
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Corresponding author

Correspondence to Goshi Nishimura.

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Cite this article

Nishimura, G., Tsukuda, M., Horiuchi, C. et al. Decrease of creatinine clearance rate with aging in patients with head and neck cancer in Japan. Int J Clin Oncol 12, 120–124 (2007). https://doi.org/10.1007/s10147-006-0635-9

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  • DOI: https://doi.org/10.1007/s10147-006-0635-9

Key words

  • Head and neck cancer
  • Ccr
  • CDDP