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Early renal cell cancer

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Abstract

Renal cell cancer (RCC) mostly arises from the proximal renal tubules and is classified as an adenocarcinoma. The most reliable treatment for RCC is surgical excision; chemotherapy or radiotherapy does not have a practical effect on RCC. In selected patients, immunotherapy, including cytokine administration, has survival benefits. There is no established definition of early RCC. Surgical removal of organ-confined disease (T1 and T2) is likely to achieve tumor-free status leading to good prognosis. Possible definitions, diagnosis and treatment options for T1 and T2 disease are discussed.

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References

  1. RJ Motzer NH Bander DM Nanus (1996) ArticleTitleRenal-cell carcinoma N Engl J Med 335 865–875 Occurrence Handle10.1056/NEJM199609193351207 Occurrence Handle1:STN:280:BymA2MjitVI%3D Occurrence Handle8778606

    Article  CAS  PubMed  Google Scholar 

  2. A Jemal T Murray A Samuels et al. (2003) ArticleTitleCancer statistics, 2003 CA Cancer J Clin 53 5–26 Occurrence Handle12568441

    PubMed  Google Scholar 

  3. Y Aso Y Homma (1992) ArticleTitleA survey on incidental renal cell carcinoma in Japan J Urol 147 340–343 Occurrence Handle1:STN:280:By2C383js1U%3D Occurrence Handle1732589

    CAS  PubMed  Google Scholar 

  4. N Lightfoot M Conlon N Kreiger et al. (2000) ArticleTitleImpact of noninvasive imaging on increased incidental detection of renal cell carcinoma Eur Urol 37 521–527 Occurrence Handle10.1159/000020188 Occurrence Handle1:STN:280:DC%2BD3c3ivFKlug%3D%3D Occurrence Handle10765089

    Article  CAS  PubMed  Google Scholar 

  5. LG Luciani R Cestari C Tallarigo (2000) ArticleTitleIncidental renal cell carcinoma – age and stage characterization and clinical implications: study of 1092 patients (1982–1997) Urology 56 58–62 Occurrence Handle10.1016/S0090-4295(00)00534-3 Occurrence Handle1:STN:280:DC%2BD3czovFyhsQ%3D%3D Occurrence Handle10869624

    Article  CAS  PubMed  Google Scholar 

  6. RC Flanigan SE Salmon BA Blumenstein et al. (2001) ArticleTitleNephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer N Engl J Med 345 1655–1659 Occurrence Handle10.1056/NEJMoa003013 Occurrence Handle1:CAS:528:DC%2BD3MXovFKjt74%3D Occurrence Handle11759643

    Article  CAS  PubMed  Google Scholar 

  7. GH Mickisch A Garin H van Poppel et al. (2001) ArticleTitleRadical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial Lancet 358 966–970 Occurrence Handle10.1016/S0140-6736(01)06103-7 Occurrence Handle1:CAS:528:DC%2BD3MXntF2qtbw%3D Occurrence Handle11583750

    Article  CAS  PubMed  Google Scholar 

  8. InstitutionalAuthorNameMedical Research Council Renal Cancer Collaborators (1999) ArticleTitleInterferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial Lancet 353 14–17

    Google Scholar 

  9. IM Thompson M Peek (1988) ArticleTitleImprovement in survival of patients with renal cell carcinoma – the role of the serendipitously detected tumor J Urol 140 487–490 Occurrence Handle1:STN:280:BieA3Mjgs1Q%3D Occurrence Handle3411657

    CAS  PubMed  Google Scholar 

  10. P Guinan LH Sobin F Algaba et al. (1997) ArticleTitleTNM staging of renal cell carcinoma: Workgroup No. 3. Union International Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC) Cancer 80 992–993 Occurrence Handle10.1002/(SICI)1097-0142(19970901)80:5<992::AID-CNCR26>3.0.CO;2-Q Occurrence Handle1:STN:280:ByiH2M%2Fns1A%3D Occurrence Handle9307205

    Article  CAS  PubMed  Google Scholar 

  11. J Javidan HJ Stricker P Tamboli et al. (1999) ArticleTitlePrognostic significance of the 1997 TNM classification of renal cell carcinoma J Urol 162 1277–1281 Occurrence Handle1:STN:280:DyaK1MvhvF2hug%3D%3D Occurrence Handle10492179

    CAS  PubMed  Google Scholar 

  12. KS Hafez AF Fergany AC Novick (1999) ArticleTitleNephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging J Urol 162 1930–1933 Occurrence Handle10.1016/S0022-5347(05)68071-8 Occurrence Handle1:STN:280:DC%2BD3c%2FjsVyhug%3D%3D Occurrence Handle10569540

    Article  CAS  PubMed  Google Scholar 

  13. M Kuczyk G Wegener AS Merseburger et al. (2005) ArticleTitleImpact of tumor size on the long-term survival of patients with early stage renal cell cancer World J Urol 23 50–54 Occurrence Handle10.1007/s00345-004-0483-z Occurrence Handle1:STN:280:DC%2BD2M7jvVGlsg%3D%3D Occurrence Handle15729558

    Article  CAS  PubMed  Google Scholar 

  14. MT Gettman ML Blute B Spotts et al. (2001) ArticleTitlePathologic staging of renal cell carcinoma: significance of tumor classification with the 1997 TNM staging system Cancer 91 354–361 Occurrence Handle10.1002/1097-0142(20010115)91:2<354::AID-CNCR1009>3.0.CO;2-9 Occurrence Handle1:STN:280:DC%2BD3M7jtl2jsA%3D%3D Occurrence Handle11180082

    Article  CAS  PubMed  Google Scholar 

  15. JM Elmore KT Kadesky KS Koeneman et al. (2003) ArticleTitleReassessment of the 1997 TNM classification system for renal cell carcinoma Cancer 98 2329–2334 Occurrence Handle10.1002/cncr.11806 Occurrence Handle14635066

    Article  PubMed  Google Scholar 

  16. WW Roberts SB Bhayani ME Allaf et al. (2005) ArticleTitlePathological stage does not alter the prognosis for renal lesions determined to be stage T1 by computerized tomography J Urol 173 713–715 Occurrence Handle10.1097/01.ju.0000153638.15018.58 Occurrence Handle15711249

    Article  PubMed  Google Scholar 

  17. S Siemer J Lehmann A Loch et al. (2005) ArticleTitleCurrent TNM classification of renal cell carcinoma evaluated: revising stage T3a J Urol 173 33–37 Occurrence Handle1:STN:280:DC%2BD2cnhvVChsQ%3D%3D Occurrence Handle15592020

    CAS  PubMed  Google Scholar 

  18. V Ficarra G Novara A Galfano et al. (2004) ArticleTitleApplication of TNM, 2002 version, in localized renal cell carcinoma: is it able to predict different cancer-specific survival probability? Urology 63 1050–1054 Occurrence Handle15183948

    PubMed  Google Scholar 

  19. T Kinouchi S Saiki N Meguro et al. (1999) ArticleTitleImpact of tumor size on the clinical outcomes of patients with Robson Stage I renal cell carcinoma Cancer 85 689–695 Occurrence Handle10.1002/(SICI)1097-0142(19990201)85:3<689::AID-CNCR19>3.0.CO;2-7 Occurrence Handle1:STN:280:DyaK1M7ptVWlsQ%3D%3D Occurrence Handle10091742

    Article  CAS  PubMed  Google Scholar 

  20. SM Bonsib (2005) ArticleTitleT2 clear cell renal cell carcinoma is a rare entity: a study of 120 clear cell renal cell carcinomas J Urol 174 IssueID4 Pt 1 1199–1202 Occurrence Handle16145369

    PubMed  Google Scholar 

  21. N Tsuboi K Horiuchi G Kimura et al. (2000) ArticleTitleRenal masses detected by general health checkup Int J Urol 7 404–408 Occurrence Handle10.1046/j.1442-2042.2000.00220.x Occurrence Handle1:STN:280:DC%2BD3M7ptVOlsg%3D%3D Occurrence Handle11144650

    Article  CAS  PubMed  Google Scholar 

  22. N Sekido T Shimazui R Noguchi et al. (1994) ArticleTitleTransabdominal ultrasonography for detection of urologic diseases in the general health check (in Japanese) Nippon Hinyokika Gakkai Zasshi (Jpn J Urol) 85 1089–1096 Occurrence Handle1:STN:280:ByuA2MbgvV0%3D

    CAS  Google Scholar 

  23. TM Mekhail RM Abou-Jawde G Boumerhi et al. (2005) ArticleTitleValidation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma J Clin Oncol 23 832–841 Occurrence Handle15681528

    PubMed  Google Scholar 

  24. RJ Motzer J Bacik M Mazumdar (2004) ArticleTitlePrognostic factors for survival of patients with stage IV renal cell carcinoma: Memorial Sloan-Kettering Cancer Center experience Clin Cancer Res 10 IssueID18 Pt 2 6302S–6303S Occurrence Handle1:CAS:528:DC%2BD2cXnvVOjsbw%3D Occurrence Handle15448021

    CAS  PubMed  Google Scholar 

  25. MA Bosniak (1986) ArticleTitleThe current radiological approach to renal cysts Radiology 158 1–10 Occurrence Handle1:STN:280:BimD28fptFc%3D Occurrence Handle3510019

    CAS  PubMed  Google Scholar 

  26. GM Israel MA Bosniak (2005) ArticleTitleAn update of the Bosniak renal cyst classification system Urology 66 484–488 Occurrence Handle10.1016/j.urology.2005.04.003 Occurrence Handle16140062

    Article  PubMed  Google Scholar 

  27. MA Bosniak (1981) ArticleTitleAngiomyolipoma (hamartoma) of the kidney: a preoperative diagnosis is possible in virtually every case Urol Radiol 3 135–142 Occurrence Handle1:STN:280:Bi2C2sjjsFc%3D Occurrence Handle7340024

    CAS  PubMed  Google Scholar 

  28. Y Yamashita S Ueno O Makita et al. (1993) ArticleTitleHyperechoic renal tumors: anechoic rim and intratumoral cysts in US differentiation of renal cell carcinoma from angiomyolipoma Radiology 188 179–182 Occurrence Handle1:STN:280:ByyB1cfos10%3D Occurrence Handle8511293

    CAS  PubMed  Google Scholar 

  29. CB Dechet T Sebo G Farrow et al. (1999) ArticleTitleProspective analysis of intraoperative frozen needle biopsy of solid renal masses in adults J Urol 162 1282–1284 Occurrence Handle10.1097/00005392-199907000-00010 Occurrence Handle1:STN:280:DyaK1MvhvF2huw%3D%3D Occurrence Handle10492180

    Article  CAS  PubMed  Google Scholar 

  30. RF Sanchez-Ortiz LT Madsen CE Bermejo et al. (2004) ArticleTitleA renal mass in the setting of a nonrenal malignancy: when is a renal tumor biopsy appropriate? Cancer 101 2195–2201 Occurrence Handle15470708

    PubMed  Google Scholar 

  31. RJ Campbell SB Broaddus GW Leadbetter SuffixJr (1985) ArticleTitleStaging of renal cell carcinoma: cost-effectiveness of routine preoperative bone scans Urology 25 326–329 Occurrence Handle10.1016/0090-4295(85)90344-9 Occurrence Handle1:STN:280:BiqC2czntFw%3D Occurrence Handle2983477

    Article  CAS  PubMed  Google Scholar 

  32. I Atlas D Kwan N Stone (1991) ArticleTitleValue of serum alkaline phosphatase and radionuclide bone scans in patients with renal cell carcinoma Urology 38 220–222 Occurrence Handle10.1016/S0090-4295(91)80348-B Occurrence Handle1:STN:280:By6A287ks1M%3D Occurrence Handle1887534

    Article  CAS  PubMed  Google Scholar 

  33. O Shvarts JS Lam HL Kim et al. (2004) ArticleTitleEastern Cooperative Oncology Group performance status predicts bone metastasis in patients presenting with renal cell carcinoma: implication for preoperative bone scans J Urol 172 867–870 Occurrence Handle10.1097/01.ju.0000135803.91207.b0 Occurrence Handle15310985

    Article  PubMed  Google Scholar 

  34. CJ Robson BM Churchill W Anderson (2002) ArticleTitleThe results of radical nephrectomy for renal cell carcinoma. 1969 J Urol 167 IssueID2 Pt 2 873–875 Occurrence Handle11905914

    PubMed  Google Scholar 

  35. RV Clayman LR Kavoussi NJ Soper et al. (1991) ArticleTitleLaparoscopic nephrectomy: initial case report J Urol 146 278–282 Occurrence Handle1:STN:280:By6A3M7nsFU%3D Occurrence Handle1830346

    CAS  PubMed  Google Scholar 

  36. Y Yoshikawa Y Ono R Hattori et al. (2004) ArticleTitleLaparoscopic partial nephrectomy for renal tumor: Nagoya experience Urology 64 259–263 Occurrence Handle10.1016/j.urology.2004.03.022 Occurrence Handle15302474

    Article  PubMed  Google Scholar 

  37. MD Shuford EM McDougall SS Chang et al. (2004) ArticleTitleComplications of contemporary radical nephrectomy: comparison of open vs laparoscopic approach Urol Oncol 22 121–126 Occurrence Handle15082009

    PubMed  Google Scholar 

  38. Y Ono R Hattori M Gotoh et al. (2005) ArticleTitleLaparoscopic radical nephrectomy for renal cell carcinoma: the standard of care already? Curr Opin Urol 15 75–78 Occurrence Handle10.1097/01.mou.0000160619.28613.3c Occurrence Handle15725928

    Article  PubMed  Google Scholar 

  39. S Permpongkosol DY Chan RE Link et al. (2005) ArticleTitleLong-term survival analysis after laparoscopic radical nephrectomy J Urol 174 IssueID4 Pt 1 1222–1225 Occurrence Handle16145374

    PubMed  Google Scholar 

  40. JJ Patard O Shvarts JS Lam et al. (2004) ArticleTitleSafety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience J Urol 171 IssueID6 Pt 1 2181–2185 Occurrence Handle15126781

    PubMed  Google Scholar 

  41. A Lapini S Serni A Minervini et al. (2005) ArticleTitleProgression and long-term survival after simple enucleation for the elective treatment of renal cell carcinoma: experience in 107 patients J Urol 174 57–60 Occurrence Handle10.1097/01.ju.0000162019.45820.53 Occurrence Handle15947577

    Article  PubMed  Google Scholar 

  42. AF Fergany KS Hafez AC Novick (2000) ArticleTitleLong-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup J Urol 163 442–445 Occurrence Handle1:STN:280:DC%2BD3c7ht1WktA%3D%3D Occurrence Handle10647650

    CAS  PubMed  Google Scholar 

  43. AC Novick (2004) ArticleTitleLaparoscopic and partial nephrectomy Clin Cancer Res 10 IssueID18 Pt 2 6322S–6327S Occurrence Handle15448025

    PubMed  Google Scholar 

  44. DB Johnson SB Solomon LM Su et al. (2004) ArticleTitleDefining the complications of cryoablation and radio frequency ablation of small renal tumors: a multi-institutional review J Urol 172 874–877 Occurrence Handle10.1097/01.ju.0000135833.67906.ec Occurrence Handle15310987

    Article  PubMed  Google Scholar 

  45. WS McDougal DA Gervais FJ McGovern et al. (2005) ArticleTitleLong-term followup of patients with renal cell carcinoma treated with radio frequency ablation with curative intent J Urol 174 61–63 Occurrence Handle15947578

    PubMed  Google Scholar 

  46. RA Rendon N Stanietzky T Panzarella et al. (2000) ArticleTitleThe natural history of small renal masses J Urol 164 1143–1147 Occurrence Handle10.1016/S0022-5347(05)67129-7 Occurrence Handle1:STN:280:DC%2BD3cvksV2hsw%3D%3D Occurrence Handle10992354

    Article  CAS  PubMed  Google Scholar 

  47. S Ozono N Miyao T Igarashi et al. (2004) ArticleTitleTumor doubling time of renal cell carcinoma measured by CT: collaboration of Japanese Society of Renal Cancer Jpn J Clin Oncol 34 82–85 Occurrence Handle10.1093/jjco/hyh011 Occurrence Handle15067101

    Article  PubMed  Google Scholar 

  48. B Ljungberg FI Alamdari T Rasmuson et al. (1999) ArticleTitleFollow-up guidelines for nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomy BJU Int 84 405–411 Occurrence Handle10.1046/j.1464-410x.1999.00202.x Occurrence Handle1:STN:280:DyaK1MzpvVyqtA%3D%3D Occurrence Handle10468753

    Article  CAS  PubMed  Google Scholar 

  49. MJ O'Dea H Zincke DC Utz et al. (1978) ArticleTitleThe treatment of renal cell carcinoma with solitary metastasis J Urol 120 540–542 Occurrence Handle712892

    PubMed  Google Scholar 

  50. RJ Cerfolio MS Allen C Deschamps et al. (1994) ArticleTitlePulmonary resection of metastatic renal cell carcinoma Ann Thorac Surg 57 339–344 Occurrence Handle1:STN:280:ByuC2crit1w%3D Occurrence Handle8311594

    CAS  PubMed  Google Scholar 

  51. DA Levy JW Slaton DA Swanson et al. (1998) ArticleTitleStage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma J Urol 159 1163–1167 Occurrence Handle1:STN:280:DyaK1c7mslansw%3D%3D Occurrence Handle9507823

    CAS  PubMed  Google Scholar 

  52. EJ Chae JK Kim SH Kim et al. (2005) ArticleTitleRenal cell carcinoma: analysis of postoperative recurrence patterns Radiology 234 189–196 Occurrence Handle15537838

    PubMed  Google Scholar 

  53. KA Furge KA Lucas M Takahashi et al. (2004) ArticleTitleRobust classification of renal cell carcinoma based on gene expression data and predicted cytogenetic profiles Cancer Res 64 4117–4121 Occurrence Handle10.1158/0008-5472.CAN-04-0534 Occurrence Handle1:CAS:528:DC%2BD2cXkvFWls78%3D Occurrence Handle15205321

    Article  CAS  PubMed  Google Scholar 

  54. BI Rini JA Sosman RJ Motzer (2005) ArticleTitleTherapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: biology, clinical results and future development BJU Int 96 286–290 Occurrence Handle10.1111/j.1464-410X.2005.05616.x Occurrence Handle1:CAS:528:DC%2BD2MXpvFehtLg%3D Occurrence Handle16042715

    Article  CAS  PubMed  Google Scholar 

  55. A Arora EM Scholar (2005) ArticleTitleRole of tyrosine kinase inhibitors in cancer therapy J Pharmacol Exp Ther 315 971–979 Occurrence Handle10.1124/jpet.105.084145 Occurrence Handle1:CAS:528:DC%2BD2MXhtlalur3L Occurrence Handle16002463

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Urology, Course of Metabolic and Regenerative Medicine, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan

    Yoshihiko Tomita

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  1. Yoshihiko Tomita
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Correspondence to Yoshihiko Tomita.

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Tomita, Y. Early renal cell cancer. Int J Clin Oncol 11, 22–27 (2006). https://doi.org/10.1007/s10147-005-0551-4

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