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Expression of vascular endothelial growth factor (VEGF)-C and -D in gastric carcinoma

International Journal of Clinical Oncology volume 11, pages 38–43 (2006)Cite this article

Abstract

Background

Both vascular endothelial growth factor (VEGF)-C and (VEGF)-D are ligands of VEGF receptor (VEGFR)-3 (Flt-4) and VEGFR-2 (KDR/FLK-1) and are supposed to participate in lymphangiogenesis. The purpose of this study was to clarify the clinical significance of the expression of these factors and to evaluate their relationship with prognosis in patients with gastric carcinoma.

Methods

Fifty pairs of normal mucosa and cancer specimens were obtained from patients who had undergone gastrectomy for primary gastric carcinoma and subjected to reverse transcriptase-polymerase chain reaction for VEGF-C, VEGF-D, and VEGFR-3.

Results

Both VEGF-C and VEGF-D mRNA expression significantly correlated with lymphatic invasion (P < 0.05). Although VEGF-C and -D were concomitantly expressed in most cases, only VEGF-C expression was related to lymph node metastasis. VEGFR-3 expression was associated both with VEGF-C and VEGF-D expression, but not with lymph node metastasis. Tumors expressing these mRNAs tended to correlate with poorer prognosis, but the relationships were not statistically significant.

Conclusion

Our study suggests that both VEGF-C and VEGF-D are involved in lymphatic spreading of gastric cancer cells, which is clinically useful for the evaluation of lymphatic invasion in patients with gastric carcinoma.

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Affiliations

  1. Department of Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan

    Atsuo Shida, Shuichi Fujioka, Katsutoshi Kobayashi, Yoshio Ishibashi, Hiroshi Nimura, Norio Mitsumori & Katsuhiko Yanaga

Authors
  1. Atsuo Shida
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  2. Shuichi Fujioka
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  3. Katsutoshi Kobayashi
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  4. Yoshio Ishibashi
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  5. Hiroshi Nimura
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  6. Norio Mitsumori
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  7. Katsuhiko Yanaga
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Corresponding author

Correspondence to Atsuo Shida.

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Shida, A., Fujioka, S., Kobayashi, K. et al. Expression of vascular endothelial growth factor (VEGF)-C and -D in gastric carcinoma. Int J Clin Oncol 11, 38–43 (2006). https://doi.org/10.1007/s10147-005-0528-3

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  • DOI: https://doi.org/10.1007/s10147-005-0528-3

Key words

  • VEGF-C
  • VEGF-D
  • Gastric carcinoma