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Safety and functional outcome analysis of ventriculoperitoneal shunt placement for hydrocephalus within the critical phase of possible delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

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Abstract

Shunt-dependent hydrocephalus (HC) is a common sequela following aneurysmal subarachnoid hemorrhage (aSAH). However, there is still poor evidence regarding the optimal timing of ventriculoperitoneal shunt (VPS) placement, particularly in the context of early aSAH-associated complications such as delayed cerebral ischemia (DCI). The purpose of this study was to compare the impact of early (< 21 days after aSAH) versus late (≥ 21 days after aSAH) VPS placement on the functional clinical outcome. We retrospectively analyzed data from 82 patients with VPS placement after aSAH enrolled in our institutional database between 2011 and 2021. We compared two groups, early VPS placement (< 21 days after aSAH) versus late VPS placement (≥ 21 days after aSAH) in terms of demographics, SAH grading, radiological parameters, externalized cerebrospinal fluid diversions, DCI, VPS variables, and functional outcome. We identified 53 patients with early and 29 patients with late VPS implantation. Baseline variables, such as the modified Rankin Scale (mRS), the World Federation of Neurological Surgeons Scale, the Glasgow Coma Scale, and Fisher grade were not significantly different between the groups. Postoperatively, the mRS (p = 0.0037), the Glasgow Outcome Scale (p = 0.0037), and the extended Glasgow Outcome Scale (p = 0.0032) showed significantly better functional results in patients with early cerebrospinal fluid diversion. The rate of DCI did not differ significantly between the groups (p = 0.53). There was no difference in the rate of VPS placement associated complications (p = 0.44) or overall mortality (p = 0.39). Early shunt implantation, within 21 days after aSAH and therefore during the timeframe of possible DCI, might not be harmful in patients developing HC after aSAH.

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Acknowledgements

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Funding

The work did not receive funding. The authors are solely responsible for the design and conduct of the presented study.

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Author notes

  1. Julien N. Jost and Yasin Irmak contributed equally and share first authorship.

Authors and Affiliations

  1. Department of Neurosurgery, Kantonsspital Aarau, Aargau, Switzerland

    Julien N. Jost, Yasin Irmak, Angelo Tortora, Serge Marbacher, Christian Musahl, Gerrit A. Schubert, Lukas Andereggen & Stefan Wanderer

  2. Department of Radiology, Division of Neuroradiology, Kantonsspital Aarau, Aargau, Switzerland

    Basil Grüter

  3. Faculty of Medicine, University of Bern, Bern, Switzerland

    Serge Marbacher & Lukas Andereggen

  4. Department of Neurosurgery, RWTH Aachen University, Aachen, Germany

    Gerrit A. Schubert

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  1. Julien N. Jost
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  2. Yasin Irmak
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Contributions

Conception and design: Jost, Wanderer. Acquisition of data: Jost, Irmak. Analysis and interpretation of data: Jost, Irmak, Andereggen, Wanderer. Drafting the article: Jost. Critically revising the article: Irmak, Grüter, Andereggen, Schubert, Wanderer. Reviewed submitted version of manuscript: all authors. Statistical analysis: Jost, Wanderer. Administrative/technical/material support: Schubert. Study supervision: Schubert, Wanderer.

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Correspondence to Julien N. Jost.

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The project was performed in accordance with the permission of the local ethics committee (Ethikkomission Nordwest- und Zentralschweiz, Switzerland, project ID 2022–00894).

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Jost, J.N., Irmak, Y., Grüter, B. et al. Safety and functional outcome analysis of ventriculoperitoneal shunt placement for hydrocephalus within the critical phase of possible delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neurosurg Rev 46, 302 (2023). https://doi.org/10.1007/s10143-023-02203-0

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