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Long-term surgical oncological and functional outcome of large petroclival and cerebellopontine angle epidermoid cysts: a multicenter study

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A Correction to this article was published on 14 April 2022

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Abstract

Cranial nerve (CN) disorders are the foremost symptoms in cerebellopontine angle (CPA) and petroclival area (PCA) epidermoid cysts (EC).The aim of this work was to  assess the long-term surgical results on CN function and tumor control in these patients. We performed a retrospective cohort study about 56 consecutive patients operated on for a CPA or PCA EC between January 2001 and July 2019 in six participating French cranial base referral centers. Sixteen patients (29%) presented a PCA EC and 40 a CPA EC (71%). The median clinical and radiological follow-up was 46 months (range 0–409). Preoperative CN disorders were present in 84% of patients (n = 47), 72% of them experienced CN deficits improvement at the last follow-up consultation (n = 34): 60% of cochlear and vestibular deficits (n = 9/15 in both groups), 67% of trigeminal neuralgia (n = 10/15), 53% of trigeminal hypoesthesia (n = 8/15), 44% of lower cranial nerve disorders (n = 4/9), 38% of facial nerve deficits (n = 5/8) and 43% of oculomotor deficits (n = 3/7) improved or were cured after surgery. New postoperative CN deficits occurred in 48% of patients (n = 27). Most of them resolved at the last follow-up, except for cochlear deficits which improved in only 14% of cases (n = 1/7). Twenty-six patients (46%) showed evidence of tumor progression after a median duration of 63 months (range 7–210). The extent of resection, tumor location, and tumor size was not associated with the occurrence of new postoperative CN deficit or tumor progression. A functional nerve-sparing resection of posterior fossa EC is an effective strategy to optimize the results on preexisting CN deficits and reduce the risk of permanent de novo deficits.

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Data availability

Data will be available upon reasonable request from a qualified investigator.

Code availability

Not applicable.

Change history

Abbreviations

BNI:

Barrow Neurological Institute

CPA:

Cerebellopontine angle

CN:

Cranial nerve(s)

DWI:

Diffusion-weighted magnetic resonance imaging

EC:

Epidermoid cyst

EOR:

Extent of resection

GTR:

Gross total resection

HB:

House and Brackmann

LCN:

Lower cranial nerves

PCA:

Petroclival area

PFS:

Progression-free survival

PR:

Partial resection

RS:

Suboccipital retrosigmoid

STR:

Subtotal Resection

TP:

Transpetrosal

WHO PS:

World Health Organization performance status

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Authors and Affiliations

  1. Department of Neurosurgery, Sainte-Anne Military Hospital, 1 Boulevard Sainte Anne, BP 20545, 83041, Toulon, France

    Aurore Sellier & Pierre-Julien Cungi

  2. Department of Neurosurgery, North University Hospital, Aix Marseille University, Marseille, France

    Lucas Troude & Pierre-Hugues Roche

  3. Department of Neurological Surgery, Grenoble University Hospital, Grenoble, France

    Clément Baumgarten & Emmanuel Gay

  4. Department of Neurosurgery, Pitié Salpêtrière Hospital, Paris, France

    Yohan Caudron & Michel Kalamarides

  5. Department of Neurosurgery, Rennes University Hospital, Rennes, France

    Maxime Bretonnier & Xavier Morandi

  6. Department of Neurosurgery, Angers University Hospital, Angers, France

    Clémentine Gallet & Henri-Dominique Fournier

  7. Department of Neurosurgery, La Timone Hospital, Aix Marseille University, Marseille, France

    Sébastien Boissonneau & Henry Dufour

Authors
  1. Aurore Sellier
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  2. Lucas Troude
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  3. Clément Baumgarten
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  5. Maxime Bretonnier
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  8. Pierre-Julien Cungi
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  9. Xavier Morandi
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  10. Henry Dufour
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  11. Henri-Dominique Fournier
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  12. Emmanuel Gay
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  13. Michel Kalamarides
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  14. Pierre-Hugues Roche
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Contributions

Author contributions to the study and manuscript preparation include the following: conception and design: Roche; acquisition of data: Sellier, Baumgarten, Caudron, Bretonnier, Gallet, Boissonneau; analysis and interpretation of data: all authors; drafting the article: Sellier, Troude, and Roche; critically revising the article: all authors; reviewed submitted version of manuscript: all authors; approved the final version of the manuscript on behalf of all authors: Roche; study supervision: Roche.

Corresponding author

Correspondence to Aurore Sellier.

Ethics declarations

Ethics approval

This study has been approved by the French Neurosurgical College Institutional Review Board (reference: IRB00011687 College de neurochirurgie IRB #1: 2020/04).

Consent to participate

No informed consent was required, as this is a retrospective analysis without any traceable patient data.

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Not applicable.

Conflict of interest

The authors declare no competing interests.

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Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The original online version of this article was revised:

The original version of this article contained a mistake in the title. The word “spetroclival” should have been written “petroclival”. The abbreviation “EC” at the end of the second sentence of the abstract should also have been deleted.

The original article has been corrected.

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Sellier, A., Troude, L., Baumgarten, C. et al. Long-term surgical oncological and functional outcome of large petroclival and cerebellopontine angle epidermoid cysts: a multicenter study. Neurosurg Rev 45, 2119–2131 (2022). https://doi.org/10.1007/s10143-021-01702-2

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  • DOI: https://doi.org/10.1007/s10143-021-01702-2

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