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Tuberculosis of the spine and drug resistance: a review article

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Abstract

Pott’s spine is tuberculosis of spine caused due to hematogenous spread of mycobacterium from a primary focus. It constitutes about 50% of skeletal tuberculosis cases. Paradiscal type is the most common type of spinal tuberculosis. Untreated cases can lead to complications like a cold abscess, paraplegia, and deformity which may require surgical intervention. Rapid molecular methods have made the diagnosis of spinal tuberculosis and drug resistance faster and easier but it still remains a problem due to difficulties in sample collection and the paucibacillary nature of the Pott spine. Antitubercular drug therapy forms the mainstay of management. The emergence of MDR TB and XDR TB has posed a big challenge in the management of spinal tuberculosis. The literature regarding drug resistance in spinal tuberculosis and its management is lacking. We conducted a literature review of 29 studies and presented information on pathogenesis, diagnosis, and management of spinal tuberculosis and drug resistance. New shorter regimens for MDR and XDR TB are under trial in different parts of the world. We believe this article will provide information on spinal tuberculosis and drug resistance and help clinicians outline important research areas.

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Authors and Affiliations

  1. Department of Orthopedics, PGIMER, Chandigarh, India

    Vishal Kumar, Deepak Neradi, Balwinder Sherry, Ankit Gaurav & Sarvdeep Singh Dhatt

Authors
  1. Vishal Kumar
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  2. Deepak Neradi
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  3. Balwinder Sherry
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  4. Ankit Gaurav
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  5. Sarvdeep Singh Dhatt
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Contributions

Vishal Kumar: final approval of the version to be published.

Deepak Neradi: critical analysis and revision of content

Balwinder Sherry: drafting of the report

Ankit Gaurav: drafting of the report

Sarvdeep Singh Dhatt: critical analysis and revision of content

Corresponding author

Correspondence to Sarvdeep Singh Dhatt.

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Kumar, V., Neradi, D., Sherry, B. et al. Tuberculosis of the spine and drug resistance: a review article. Neurosurg Rev 45, 217–229 (2022). https://doi.org/10.1007/s10143-021-01595-1

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