Prognostic nomogram for microvascular decompression–treated trigeminal neuralgia


This study aimed to establish an effective prognostic nomogram for microvascular decompression (MVD)–treated trigeminal neuralgia (TN). The nomogram was based on a retrospective cohort study of 1054 patients with TN. During the period 2005–2014, 845 patients at our department treated TN with MVD and served as a development cohort. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve. The model was externally validated by 209 TN patients during 2014–2016. Multivariate cox analysis suggested that the patient’s age, atypical pain, vascular type, number of offending vessels, and second MVD were significant factors influencing the prognosis of MVD-treated TN. The C index of nomogram in the development cohort was 0.767 (95% CI, 0.739–0.794), and 0.749 (95% CI, 0.688–0.810) in the validation cohort. We developed and validated a nomogram to predict 3-year overall remission rate after MVD treatment of TN. The nomogram can be used in clinical trials to determine the likelihood of pain recurrence in TN patients treated with MVD for 3 years to aid in the comprehensive treatment of TN.

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The authors acknowledge the collaboration of all of the staff and technical members at Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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Correspondence to Xiao-Qiang Wang.

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The authors declare that they have no conflict of interest.

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This study has been approved by the Institutional Ethics Committee of Xinhua Hospital and was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments. For this retrospective study, formal consent was not required.

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Informed consent was obtained from all individual participants who were included in the study.

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Wen-Bo Zhang, Ya-Ying Zeng, and Bo-Wen Chang are co-first authors to the article.

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Zhang, WB., Zeng, YY., Chang, BW. et al. Prognostic nomogram for microvascular decompression–treated trigeminal neuralgia. Neurosurg Rev 44, 571–577 (2021).

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  • Trigeminal neuralgia
  • Remission rate
  • Microvascular decompression
  • Nomogram
  • Predictive model