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Angiosarcoma-related cerebral metastases: a systematic review of the literature

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Abstract

Angiosarcoma-related cerebral metastases have only been recorded in a few case reports and case series and have not been systematically reviewed to date. Our objective was therefore to perform a systematic literature review on cases of angiosarcomas metastasizing to the brain to inform current practice. All three major libraries—PubMed/MEDLINE, Embase, and Cochrane—were systematically searched, until January 2019. Articles in English reporting angiosarcoma-related cerebral metastases via hematogenous route were included. Our search yielded 45 articles (38 case reports, 5 retrospective studies, 1 case series and 1 letter to the editor), totaling 48 patients (mean age 47.9 years). The main primary site was the heart. The mean time of diagnosis of cerebral metastases following primary tumor identification was 4.9 months. In 15 cases, the brain was the only metastatic site. In cases of multiple extracerebral metastases, the most common sites were the lung and bone. Acute intracerebral supratentorial hemorrhage was the most common presenting radiological feature. Treatment strategies were almost equally divided between the surgical (with or without adjuvant treatment) and the medical arm. Mean overall survival was 7.2 months while progression-free survival was 1.5 months. To our knowledge, this is the first systematic literature review on angiosarcoma-related cerebral metastases. This pathology proves to be an extremely rare clinical entity and carries a poor prognosis, and no consensus has been reached regarding treatment.

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References

  1. Akutsu H, Tsuboi K, Sakamoto N, Nose T, Honma S, Jikuya T (2004) Cerebral metastasis from angiosarcoma of the aortic wall: case report. Surg Neurol 61:68–71. https://doi.org/10.1016/S0090-3019%2803%2900297-0

    Article  PubMed  Google Scholar 

  2. Angrish K, Manchanda SC, Shankar SK, Chopra P (1979) Primary angiosarcoma of the heart. Jpn Heart J 20:375–380

    CAS  PubMed  Google Scholar 

  3. Bassanelli M, Viterbo A, Roberto M, Giacinti S, Staddon A, Aschelter AM, D’Antonio C, Marchetti P (2016) Multimodality treatment of brain metastases from renal cell carcinoma in the era of targeted therapy. Ther Adv Med Oncol 8:450–459

    CAS  PubMed Central  Google Scholar 

  4. Bennani O, Derrey S, Langlois O, Castel H, Laquerriere A, Freger P, Proust F (2014) Brain metastasis from renal cell carcinoma. Neurochirurgie 60:12–16

    CAS  PubMed  Google Scholar 

  5. Bhatt MD, Nambudiri VE (2019) Cutaneous sarcomas. Hematol Oncol Clin North Am 33:87–101. https://doi.org/10.1016/j.hoc.2018.08.007

    Article  PubMed  Google Scholar 

  6. Bien E, Stachowicz-Stencel T, Balcerska A, Godzinski J, Kazanowska B, Perek-Polnik M, Madziara W, Rybczynska A, Kurylak A, Zalewska-Szewczyk B, Peregud-Pogorzelski J (2009) Angiosarcoma in children still uncontrollable oncological problem. The report of the Polish paediatric rare tumours study. Eur J Cancer Care 18:411–420. https://doi.org/10.1111/j.1365-2354.2008.01063.x

    Article  CAS  Google Scholar 

  7. Booth AM, LeGallo RD, Stoler MH, Waldron PE, Cerilli LA (2001) Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. Pediatr Dev Pathol 4:490–495

    CAS  PubMed  Google Scholar 

  8. Chaudhuri R, Jager R, Bridger J, Fusi L, Thomas D, Frackowiak R (1994) Hemiplegia in pregnancy due to metastatic cerebral angiosarcoma. Eur Neurol 34:295–297

    CAS  PubMed  Google Scholar 

  9. Chiarion-Sileni V, Guida M, Ridolfi L, Romanini A, Del Bianco P, Pigozzo J, Brugnara S, Colucci G, Ridolfi R, De Salvo G (2011) Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide-and dacarbazine-based regimens. Br J Cancer 104:1816

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Cohen JV, Tawbi H, Margolin KA, Amravadi R, Bosenberg M, Brastianos PK, Chiang VL, de Groot J, Glitza IC, Herlyn M (2016) Melanoma central nervous system metastases: current approaches, challenges, and opportunities. Pigment Cell Melanoma Res 29:627–642

    PubMed  PubMed Central  Google Scholar 

  11. D’Antonio C, Passaro A, Gori B, Del Signore E, Migliorino MR, Ricciardi S, Fulvi A, De Marinis F (2014) Bone and brain metastasis in lung cancer: recent advances in therapeutic strategies. Ther Adv Med Oncol 6:101–114

    PubMed  PubMed Central  Google Scholar 

  12. De Felice F, Moscatelli E, Orelli S, Bulzonetti N, Musio D, Tombolini V (2018) Primary thyroid angiosarcoma: a systematic review. Oral Oncol 82:48–52. https://doi.org/10.1016/j.oraloncology.2018.05.004

    Article  PubMed  Google Scholar 

  13. Dea N, Pelmus M, Mathieu D, Belzile F, Bergeron D, Gosselin S, Tsanaclis AM (2009) 64-year-old man with multiple cerebral lesions. Brain Pathol 19:535–538

    PubMed  PubMed Central  Google Scholar 

  14. Delattre JY, Krol G, Thaler HT, Posner JB (1988) Distribution of brain metastases. Arch Neurol 45:741–744

    CAS  PubMed  Google Scholar 

  15. Duncan MA, Lautner MA (2018) Sarcomas of the breast. Surg Clin North Am 98:869–876. https://doi.org/10.1016/j.suc.2018.03.013

    Article  PubMed  Google Scholar 

  16. Eguchi K, Ishi S, Sugiura H, Noga K (2002) Angiosarcoma of the chest wall in a patient with fibrous dysplasia. Eur J Cardiothorac Surg 22:654–655

    CAS  PubMed  Google Scholar 

  17. Falk S, Krishnan J, Meis JM (1993) Primary angiosarcoma of the spleen: a clinicopathologic study of 40 cases. Am J Surg Pathol 17:959–970

    CAS  PubMed  Google Scholar 

  18. Fatih A, Melih C, Ozgur K, Feyzi SB, Kadir T, Fazilet K (2014) Brain metastasis from cardiac angiosarcoma. Neurol India 62

  19. Fatima J, Duncan AA, Maleszewski JJ, Kalra M, Oderich GS, Gloviczki P, Suri RM, Bower TC (2013) Primary angiosarcoma of the aorta, great vessels, and the heart. J Vasc Surg 57:756–764. https://doi.org/10.1016/j.jvs.2012.09.023

    Article  PubMed  Google Scholar 

  20. Fenske DC, Price GL, Hess LM, John WJ, Kim ES (2017) Systematic review of brain metastases in patients with non–small-cell lung cancer in the United States, European Union, and Japan. Clin Lung Cancer 18:607–614

    PubMed  Google Scholar 

  21. Florou V, Wilky BA (2018) Current and future directions for angiosarcoma therapy. Curr Treat Options Oncol 19:14

    PubMed  Google Scholar 

  22. Furihata M, Takeuchi T, Iwata J, Sonobe H, Ohtsuki Y, Wakatsuki A, Morioka N, Sagara Y (1998) Primary ovarian angiosarcoma: a case report and literature review. Pathol Int 48:967–973

    CAS  PubMed  Google Scholar 

  23. Gaballah AH, Jensen CT, Palmquist S, Pickhardt PJ, Duran A, Broering G, Elsayes KM (2017) Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol 90:20170039

    PubMed  PubMed Central  Google Scholar 

  24. Gallo P, Dini LI, Saraiva GA, Sonda I, Isolan G (2001) Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report. Arq Neuropsiquiatr 59:793–796

    CAS  PubMed  Google Scholar 

  25. Gaudino S, Di Lella GM, Russo R, Russo VL, Piludu F, Quaglio FR, Gualano MR, De Waure C, Colosimo C (2012) Magnetic resonance imaging of solitary brain metastases: main findings of nonmorphological sequences. Radiol Med 117:1225–1241

    CAS  PubMed  Google Scholar 

  26. Gavrilovic IT, Posner JB (2005) Brain metastases: epidemiology and pathophysiology. J Neuro-Oncol 75:5–14. https://doi.org/10.1007/s11060-004-8093-6

    Article  Google Scholar 

  27. Goldberg SB, Contessa JN, Omay SB, Chiang V (2015) Lung cancer brain metastases. Cancer J 21:398–403

    PubMed  Google Scholar 

  28. Grafino M, Alves P, de Almeida MM, Garrido P, Hasmucrai D, Teixeira E, Sotto-Mayor R (2016) Angiosarcoma of the lung. J Bras Pneumol 42:68–70. https://doi.org/10.1590/S1806-37562016000000193

    Article  PubMed  PubMed Central  Google Scholar 

  29. Guan H, Zhang L, Zhang Q, Qi W, Xie S, Hou J, Wang H (2018) Primary angiosarcoma arising in an angiomyolipoma of the kidney: case report and literature review. Diagn Pathol 13:53. https://doi.org/10.1186/s13000-018-0730-z

    Article  PubMed  PubMed Central  Google Scholar 

  30. Harris JD, Quatman CE, Manring M, Siston RA, Flanigan DC (2014) How to write a systematic review. Am J Sports Med 42:2761–2768

    PubMed  Google Scholar 

  31. Ikeya E, Taguchi J, Yamaguchi M, Shibuya M, Kanabuchi K (2006) Primary cardiac angiosarcoma: presenting with cardiac tamponade followed by cerebral hemorrhage with brain metastases. Jpn J Thorac Cardiovasc Surg 54:528–531. https://doi.org/10.1007/s11748-006-0063-9

    Article  PubMed  Google Scholar 

  32. Jain A, Simon S, Elangovan I (2015) 18F-fluoro-deoxyglucose positron emission tomography-computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: a rare case report and review of the literature. Indian J Nucl Med 30:51

    PubMed  PubMed Central  Google Scholar 

  33. Jung S-H, Jung T-Y, Joo S-P, Kim H-S (2012) Rapid clinical course of cerebral metastatic angiosarcoma from the heart. J Korean Neurosurg Soc 51:47

    PubMed  PubMed Central  Google Scholar 

  34. Kadota S, Matsuda M, Umei N, Izuhara M, Baba O, Mitsuoka H, Shioji K, Uegaito T, Satsu T, Onoe M, Kadota E (2010) A case of right atrial angiosarcoma: the utility of PET and CT fusion imaging in detecting a malignant cardiac tumor. J Cardiol Cases 1:e84–e87. https://doi.org/10.1016/j.jccase.2009.08.002

    Article  PubMed  Google Scholar 

  35. Kardes O, Aydemir F, Suner HI, Durdag E, Civi S, Tufan K, Kayaselcuk F (2018) Brain Metastasis Of Penile Angiosarcoma. Urol J 15:53–55

    PubMed  Google Scholar 

  36. Kuratsu J-i, Seto H, Kochi M, Itoyama Y, Uemura S, Ushio Y (1991) Metastatic angiosarcoma of the brain. World Neurosurg 35:305–309

    CAS  Google Scholar 

  37. Liassides C, Katsamaga M, Deretzi G, Koutsimanis V, Zacharakis G (2004) Cerebral metastasis from heart angiosarcoma presenting as multiple hematomas. J Neuroimaging 14:71–73

    PubMed  Google Scholar 

  38. Lin C, Ducis K, Tucker S, Tranmer B (2017) Metastatic cardiac angiosarcoma to the lung, spine, and brain: a case report and review of the literature. World Neurosurg 107:1049. e1049

    Google Scholar 

  39. Liu C, Zhao Y, Yin Z, Hu T, Ren J, Wei J, Xie L, Xiong J, Wu H, Dai X (2018) Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy: a case report and literature review. Medicine 97

  40. Liu Q, Yin X, Yao J, Zeng H, Zhou Q, Chen N (2018) Case report primary angiosarcoma of the prostate: a case report and literature review. Int J Clin Exp Med 11:11304–11308

    Google Scholar 

  41. Macaulay RAA (1978) Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. J Neurol Neurosurg Psychiatry 41:474–478

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Maglaras GC, Katsenos S, Kakadelis J, Katsanos C, Metafratzi Z, Stefanou DG, Vassiliou MP, Constantopoulos SH (2004) Primary angiosarcoma of the lung and pleura. Monaldi Arch Chest Dis - Pulmonary Series 61:234–236

    CAS  Google Scholar 

  43. Masih I, McIlwaine W (2010) Metastatic angiosarcoma: a vascular tumour or an intracranial haemorrhage? BMJ Case Rep

  44. Matsuno A, Nagashima T, Tajima Y, Sugano I (2005) A diagnostic pitfall: angiosarcoma of the brain mimicking cavernous angioma. J Clin Neurosci 12:688–691

    PubMed  Google Scholar 

  45. Mecklai A, Rosenzweig B, Applebaum R, Axel L, Grossi E, Chan A, Saric M (2014) Intimal sarcoma in the aortic arch partially obstructing the aorta with metastasis to the brain. Tex Heart Inst J 41:433–436

    PubMed  PubMed Central  Google Scholar 

  46. Nai Q, Ansari M, Liu J, Razjouyan H, Pak S, Tian Y, Khan R, Broder A, Bagchi A, Iyer V, Hamouda D, Islam M, Sen S, Yousif A, Hu M, Lou Y, Duhl J (2018) Primary small intestinal angiosarcoma: epidemiology, diagnosis and treatment. J Clin Med Res 10:294–301. https://doi.org/10.14740/jocmr3153w

    Article  PubMed  PubMed Central  Google Scholar 

  47. Nowak-Sadzikowska J, Walasek T, Jakubowicz J, Blecharz P, Reinfuss M (2016) Current treatment options of brain metastases and outcomes in patients with malignant melanoma. Rep Pract Oncol Radiother 21:271–277

    PubMed  Google Scholar 

  48. Oliva IG, Tawbi H, Davies MA (2017) Melanoma brain metastases: current areas of investigation and future directions. Cancer J (Sudbury, Mass) 23:68

    Google Scholar 

  49. Omiyale AO, Carton J (2018) Clinical and pathologic features of primary angiosarcoma of the kidney. Curr Urol Rep 19:4. https://doi.org/10.1007/s11934-018-0755-6

    Article  PubMed  Google Scholar 

  50. Pacini D, Careddu L, Pantaleo A, Parolari A, Leone O, Daprati A, Gargiulo GD, Di Bartolomeo R (2015) Primary malignant tumors of the heart: outcomes of the surgical treatment. Asian Cardiovasc Thorac Ann 23:645–651

    PubMed  Google Scholar 

  51. Patchell RA (2003) The management of brain metastases. Cancer Treat Rev 29:533–540

    PubMed  Google Scholar 

  52. Pekmezci M, Perry A (2013) Neuropathology of brain metastases. Surg Neurol Int 4:S245–S255. https://doi.org/10.4103/2152-7806.111302

    Article  PubMed  PubMed Central  Google Scholar 

  53. Ploegmakers MJM, Pruszczynski M, De Rooy J, Kusters B, Veth RPH (2005) Angiosarcoma with malignant peripheral nerve sheath tumour developing in a patient with Klippel-Trenaunay-Weber syndrome. Sarcoma 9:137–140. https://doi.org/10.1080/13577140500353743

    Article  PubMed  PubMed Central  Google Scholar 

  54. Plotnik AN, Schweder P, Tsui A, Kavar B (2008) Splenic angiosarcoma metastasis to the brain. J Clin Neurosci 15:927–929. https://doi.org/10.1016/j.jocn.2007.03.028

    Article  PubMed  Google Scholar 

  55. Pötter R, Baumgart P, Greve H, Schnepper E (1989) Primary angiosarcoma of the heart. Thorac Cardiovasc Surg 37:374–378

    PubMed  Google Scholar 

  56. Rai S, Barthwal M, Bhattacharya P, Bhargava S, Pethe M (2008) Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage. Lung India 25:14

    PubMed  PubMed Central  Google Scholar 

  57. Ramachandren TK, Venkataraman K, Hussey K, Ferguson L (2016) Metastatic angiosarcoma presenting as ischemic anterior circulation stroke. Ann Vasc Surg 31:209.e207–209.e209. https://doi.org/10.1016/j.avsg.2015.08.025

    Article  Google Scholar 

  58. Rettmar K, Stierle U, Sheikhzadeh A, Diederich KW (1993) Primary angiosarcoma of the heart. Report of a case and review of the literature. Jpn Heart J 34:667–683

    CAS  PubMed  Google Scholar 

  59. Rostami R, Mittal S, Rostami P, Tavassoli F, Jabbari B (2016) Brain metastasis in breast cancer: a comprehensive literature review. J Neuro-Oncol 127:407–414

    CAS  Google Scholar 

  60. Scharl M, Bode B, Rushing E, Knuth A, Rordorf T (2014) Uncommon case of brain metastasis in a patient with a history of heavy smoking. Curr Oncol 21:e728–e731. https://doi.org/10.3747/co.21.1880

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Schouten LJ, Rutten J, Huveneers HA, Twijnstra A (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94:2698–2705

    PubMed  Google Scholar 

  62. Sherid M, Sifuentes H, Brasky J, Shah DA, Ehrenpreis ED (2013) Clinical and endoscopic features of angiosarcoma of the colon: two case reports and a review of the literature. J Gastrointest Cancer 44:12–21

    PubMed  Google Scholar 

  63. Shimabukuro I, Yatera K, Noguchi S, Kawanami Y, Iwanami T, Nishida C, Yamasaki K, Kawanami T, Ishimoto H, So T, Uramoto H, Yoshii C, Tanaka F, Mukae H (2015) Primary pulmonary angiosarcoma presenting with hemoptysis and ground-glass opacity: a case report and literature review. Tohoku J Exp Med 237:273–278. https://doi.org/10.1620/tjem.237.273

    Article  CAS  PubMed  Google Scholar 

  64. Shweikeh F, Bukavina L, Saeed K, Sarkis R, Suneja A, Sweiss F, Drazin D (2014) Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes. Sarcoma 2014. https://doi.org/10.1155/2014/475175

  65. Singla S, Papavasiliou P, Powers B, Gaughan J, Von Mehren M, Watson JC, Farma JM (2014) Challenges in the treatment of angiosarcoma: a single institution experience. Am J Surg 208:254–259. https://doi.org/10.1016/j.amjsurg.2014.01.007

    Article  PubMed  Google Scholar 

  66. Sinha R, Sage W, Watts C (2017) The evolving clinical management of cerebral metastases. Eur J Surg Oncol 43:1173–1185

    CAS  PubMed  Google Scholar 

  67. Sleszycka JA, Sioma A, Mazurkiewicz L, Klisiewicz A, Michalowska I, Kocanda S, Walczak E, Langfort R, Klimczak A, Grzybowski J (2013) Cardiac angiosarcoma with the presence of mycobacterium tuberculosis complex genetic material. Eur Heart J 34:1125–1126

    Google Scholar 

  68. Søndenaa K, Heikkilä R, Nysted A, Søreide JA, Ødegaard H, Pollard ML, Holter J (1993) Diagnosis of brain metastases from a primary hemangiosarcoma of the spleen with magnetic resonance imaging. Cancer 71:138–141

    PubMed  Google Scholar 

  69. Stelzer KJ (2013) Epidemiology and prognosis of brain metastases. Surg Neurol Int 4:S192

    PubMed  PubMed Central  Google Scholar 

  70. Strohl KP (1976) Angiosarcoma of the heart: a case study. Arch Intern Med 136:928–929

    CAS  PubMed  Google Scholar 

  71. Suki D, Khoury Abdulla R, Ding M, Khatua S, Sawaya R (2014) Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center. J Neurosurg Pediatr 14:372–385

    PubMed  Google Scholar 

  72. van IDGP, Bovee J (2017) Vascular tumors of bone: the evolvement of a classification based on molecular developments. Surg Pathol Clin 10:621–635. https://doi.org/10.1016/j.path.2017.04.003

    Article  Google Scholar 

  73. Vaquero J, Martinez R, Coca S, Oya S, Burgos R (1990) Cerebral metastasis from angiosarcoma of the heart: case report. J Neurosurg 73:633–635

    CAS  PubMed  Google Scholar 

  74. Vermander F, Geerts ML, Kint A (1982) Angiosarcoma of the scalp and the face with a cerebral metastasis. Dermatologica 165:529–530

    Google Scholar 

  75. Wang Q, Zhao T, Mi BT, Zhang YL, Wei R, Tong HL, Wu M (2018) Primary colonic angiosarcoma seen in a patient on calcium channel blocker: a case report with summary analysis of 32 other cases from the literature. Am J Case Rep 19:254–261

    PubMed  PubMed Central  Google Scholar 

  76. Wasmer JM, Block NL, Politano VA, Tejada F (1981) Penile angiosarcoma presenting in bladder. Urology 18:179–180

    CAS  PubMed  Google Scholar 

  77. Yanagawa B, Mazine A, Chan EY, Barker CM, Gritti M, Reul RM, Ravi V, Ibarra S, Shapira OM, Cusimano RJ (2018) Surgery for tumors of the heart. In: Seminars in thoracic and cardiovascular surgery. Elsevier, Amsterdam

    Google Scholar 

  78. Young RJ, Woll PJ (2017) Anti-angiogenic therapies for the treatment of angiosarcoma: a clinical update. Memo 10:190–193. https://doi.org/10.1007/s12254-017-0365-x

    Article  PubMed  PubMed Central  Google Scholar 

  79. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ (2010) Angiosarcoma. Lancet Oncol 11:983–991

    PubMed  Google Scholar 

  80. Zakaria Z, Tambirajoo K, Sattar MT, Farrell MA (2015) Rapid clinical course of multiple metastatic cerebral angiosarcoma. Turk Neurosurg 25:643–648. https://doi.org/10.5137/1019-5149.JTN.9042-13.1

    Article  PubMed  Google Scholar 

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  1. Evangelos Drosos and Aristotelis Kalyvas contributed equally to this work.

Authors and Affiliations

  1. Athens Microneurosurgery Laboratory, Ploutarhou 3, Athens, Greece

    Evangelos Drosos, Aristotelis Kalyvas, Spyridon Komaitis, Georgios P. Skandalakis, George Stranjalis & Christos Koutsarnakis

  2. Department of Neurosurgery, Evangelismos Hospital, National and Kapodistrian University of Athens, Ypsilantou 45-47, Athens, Greece

    Evangelos Drosos, Aristotelis Kalyvas, Spyridon Komaitis, Eleftherios Neromyliotis, George Stranjalis & Christos Koutsarnakis

  3. Hellenic Center for Neurosurgical Research “Petros Kokkalis”, Ploutarxhou 3, Athens, Greece

    Aristotelis Kalyvas, Spyridon Komaitis, Theodosis Kalamatianos, Evangelia Liouta, George Stranjalis & Christos Koutsarnakis

  4. Neurosurgery Department, University of Ioannina, Leof. Stavrou Niarchou, Ioannina, Greece

    George A. Alexiou

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Drosos, E., Kalyvas, A., Komaitis, S. et al. Angiosarcoma-related cerebral metastases: a systematic review of the literature. Neurosurg Rev 43, 1019–1038 (2020). https://doi.org/10.1007/s10143-019-01127-y

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