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Correlation between glioma location and preoperative seizures: a systematic review and meta-analysis

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Abstract

Epilepsy is a common manifestation of glioma patients and negatively impacts on quality of life and neurocognitive function. The risk of preoperative seizures in patients with glioma is currently under discussion. We aimed to evaluate the relationship between tumor locations in the cerebrum and preoperative seizures in patients with glioma. PubMed, EMBASE, Web of Science, China Biology Medicine, and the Cochrane Library were systematically searched from inception to July 15, 2017, for original studies including reports of preoperative seizures in patients with gliomas in different brain regions. The pooled odds ratio (OR) and 95% confidence interval (CI) of the meta-analysis for preoperative seizure risk stratified by cerebrum regions were calculated. The quality of evidence was assessed per outcome, using the approach of the Grades of Recommendation, Assessment, Development and Evaluation. Overall, 4323 participants in 16 population-based studies were included in this meta-analysis. The meta-analysis indicated that gliomas in the frontal lobe (OR = 1.51, 95% CI = 1.09–2.09, P = 0.013) were associated with a higher risk for preoperative seizure compared to occipital lobe involved (OR = 0.53, 95% CI = 0.32–0.88, P = 0.014). Regarding the other three lobe involved gliomas, no difference was found between the incidence of preoperative seizures and tumor location. Current limited data suggest that frontal gliomas were associated with a higher risk of preoperative seizures, while gliomas in the occipital lobe were associated with a lower seizure risk. Further RCT studies recruiting larger sample sizes are required to validate these results and guide clinical practice.

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Authors and Affiliations

  1. Department of Neurology, Gansu Provincial Hospital, Dong gang West Road, Lanzhou, 730000, Gansu, China

    Jian Zhang, Shaopeng Peng & Jianxiong Liu

  2. Clinical Evidence Based Medicine Center, Gansu Provincial Hospital, Dong gang West Road, Lanzhou, 730000, Gansu, China

    Liang Yao

  3. Department of Endocrinology, Gansu Provincial Hospital, Dong gang West Road, Lanzhou, 730000, Gansu, China

    Yuan Fang

  4. School of Clinical Medical Sciences, Ningxia Medical University, Yinchuan, 750004, Ningxia, China

    Ruitian Tang

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  1. Jian Zhang
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  3. Shaopeng Peng
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  4. Yuan Fang
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Correspondence to Jianxiong Liu.

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Appendices

Appendix 1

Table 6 Search strategies
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Appendix 2

Table 7 The inception date of each database
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Appendix 3

Table 8 The 2007 WHO grading of tumors of the central nervous system
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Zhang, J., Yao, L., Peng, S. et al. Correlation between glioma location and preoperative seizures: a systematic review and meta-analysis. Neurosurg Rev 42, 603–618 (2019). https://doi.org/10.1007/s10143-018-1014-5

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