Prognostic and clinicopathological significance of long non-coding RNA in glioma

  • Junhong Li
  • Ruofei Liang
  • Chen Song
  • Yufan Xiang
  • Yanhui Liu


Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identified through multiple research strategies in PubMed, EMBASE, Web of Science, and Cochrane Library up to May 2017. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were utilized to calculate patient’s survival. Fourteen eligible studies with 1415 patients were ultimately included in this meta-analysis. Our meta-analysis showed a significant association between high lncRNA expression level and OS in glioma patients (HR 2.09, 95% CI 1.68–2.58, P < 0.001). Subgroup analysis was conducted to explore the potential heterogeneity. As for clinicopathological parameters, lncRNA expression was significantly associated with tumor diameter (< 3 vs ≥ 3 cm, OR 0.39, 95% CI 0.27–0.56, P < 0.001; < 5 vs ≥ 5 cm, OR 0.56, 95% CI 0.34–0.92, P = 0.02), tumor grade (OR 0.21, 95% CI 0.13–0.34, P < 0.001), and Karnofsky Performance Status Scale (OR 2.52, 95% CI 1.54–4.11, P < 0.001). LncRNA may serve as a biomarker for prognosis and clinicopathological features in glioma patients.


Long non-coding RNA Glioma Prognosis Characteristic features 


Author’s contribution

Study design: Yanhui Liu, Junhong Li, Ruofei Liang.

Literature search: Ruofei Liang, Chen Song, Yufan Xiang.

Data collection: Junhong Li, Ruofei Liang.

Statistical analysis: Junhong Li, Yufan Xiang.

Result interpretation: Yanhui Liu, Junhong Li, Ruofei Liang.

Manuscript preparation: Junhong Li, Ruofei Liang.


This study was supported by the Key Research and Development Project from the Department of Science and Technology of Sichuan Province, China (grant number 2017SZ0006). The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryWest China Hospital of Sichuan UniversityChengduPeople’s Republic of China

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