Abstract
There is growing evidence that the nervous system influences spinal cord vasculature. However, most descriptions of the spinal cord have paid little attention to this important aspect. We reviewed the literature on the innervation of spinal cord vessels with an emphasis on findings that may be applicable to human medicine. Multiple neurotransmitters and competing theories have been implicated in the neural regulation of spinal cord blood vessels. Identifying valid mechanisms of pathogenesis could be beneficial to human patients with spinal cord lesions. We discuss the various findings on the neural mechanisms behind spinal cord blood flow. Further investigation is warranted due to the current emphasis on comparative animal studies without corresponding corroborative human findings.
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References
Hegde SA, Hara H, Kobayashi S (1988) Innervation of radicular and extraparenchymal arteries of spinal cord: histochemical and immunohistochemical study in primate. Histochemistry 89:415–420
Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen-Gadol AA (2015) Blood supply to the human spinal cord: part I. Anatomy and hemodynamics. Clin Anat 28(1):52–64
Bosmia AN, Tubbs RS, Hogan E, Bohnstedt BN, Denardo AJ, Loukas M, Cohen-Gadol AA (2015) Blood supply to the human spinal cord: part II. Imaging and pathology. Clin Anat 28(1):65–74
Griessenauer CJ, Raborn J, Foreman P, Shoja MM, Loukas M, Tubbs RS (2015) Venous drainage of the spine and spinal cord: a comprehensive review of its history, embryology, anatomy, physiology, and pathology. Clin Anat 28(1):75–87
Motavkin PA (1964) Innervation of spinal cord blood vessels. Arkh Anat Gistol Embriol 46(6):56–64
Tator CH, Koyanagi I (1997) Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 86:483–492
Itakura T (1983) Aminergic and cholinergic innervations of the spinal cord blood vessels of cats: a histochemical study. J Neurosurg 58:900–905
Hickey R, Albin MS, Bunegin L, Gelineau J (1986) Autoregulation of spinal cord blood flow: is the cord a microcosm of the brain? Stroke 17(6):1183–1189
Di Carlo V (1984) Segmental serotoninergic innervation of spinal cord arterial circulation. Neurosci Lett 49:225–231
Amenta F, Bronzetti E, Cavallotti C, Felici L (1987) Quantitative image analysis of the density and pattern of adrenergic innervation of blood vessels of rat spinal cord. J Auton Nerv Syst 18:261–264
Amenta F, Bronzetti E, Ferrante F, Ricci A (1990) The noradrenergic innervation of spinal cord blood vessels in old rats. Neurobiol Aging 11:47–50
Hara H, Kobayashi S (1987) Adrenergic innervation of the vasa nervorum in the cranial nerves and spinal roots in the subarachnoid space. Exp Neurol 98:673–676
Bingham WG, Sirinek L, Crutcher K, Mohnacky C (1977) Effect of spinal cord injury on cord and cerebral blood flow in monkey. Acta Neurol Scand Suppl 64:238–239
McNicholas LF, Martin WR, Sloan JW, Nozaki M (1980) Innervation of the spinal cord by sympathetic fibers. Exp Neurol 69:383–394
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Montalbano, M.J., Loukas, M., Oskouian, R.J. et al. Innervation of the blood vessels of the spinal cord: a comprehensive review. Neurosurg Rev 41, 733–735 (2018). https://doi.org/10.1007/s10143-016-0788-6
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DOI: https://doi.org/10.1007/s10143-016-0788-6