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The incidence of cerebral amyloid angiopathy in surgically treated intracranial hemorrhage in the Chinese population

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Abstract

Despite being widely accepted as an important cause of spontaneous intracranial hemorrhage (ICH), cerebral amyloid angiopathy (CAA) has seldom been studied in the Chinese population. The current study aims to investigate the incidence and features of CAA in surgically treated ICH patients in China. From May 2006 to April 2011, 974 patients admitted to 71 hospitals throughout China for acute spontaneous ICH were studied. Craniotomy for hematoma evacuation was performed. Brain tissue from the superficial side of the suspected residual hematoma cavity, as well as from the cortex and subcortex, was obtained. Congo Red stain and β-amyloid immunohistochemistry were used for the diagnosis. Each case was assigned a pathological severity score. Of the 974 involved patients, 37.7 % were identified with CAA of different degrees. CAA had positive correlation with age and was independent of sex. Most patients had mild CAA with only the superficial vessels involved in lobes instead of the basal ganglia; the patients ≥65 years had more severe pathological score of CAA than those <65 years and had more lobes and cerebellum involved than the latter. More than one third of the surgically treated Chinese ICH patients may have CAA of different degrees.

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Acknowledgments

This study was supported by The Ministry of Science and Technology, People's Republic of China (2006BAI01A13). The authors want to thank all the 71 hospitals for the brain samples and information (listed in the supplement). Special thanks to Dr. Alexander G. Weil for the language assistance (programme de neurosurgery, Notre-Dame Hospital, University of Montreal, Montreal, Canada).

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Chongwen District, 100050, Beijing, China

    Ya-juan Tang, Shuo Wang & Ji-zong Zhao

  2. Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China

    Ming-wei Zhu

  3. Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Yong Li

  4. Department of Ultropathology, Beijing Neurosurgical Institute, Beijing, China

    Yi-lin Sun

Authors
  1. Ya-juan Tang
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  2. Yong Li
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  3. Shuo Wang
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  4. Ming-wei Zhu
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  5. Yi-lin Sun
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  6. Ji-zong Zhao
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Corresponding author

Correspondence to Ji-zong Zhao.

Additional information

Yajuan Tang and Yong Li contributed equally to this article and list as co- first author.

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Tang, Yj., Li, Y., Wang, S. et al. The incidence of cerebral amyloid angiopathy in surgically treated intracranial hemorrhage in the Chinese population. Neurosurg Rev 36, 533–539 (2013). https://doi.org/10.1007/s10143-013-0474-x

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  • DOI: https://doi.org/10.1007/s10143-013-0474-x

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