Abstract
Intraorbital lymphoma is a rare event. The aim of this study was to evaluate the clinical features, management, and outcome of patients with intraorbital lymphoma. The data of twenty-one individuals (12 women, nine men, aged 33 years to 84 years, mean age 62 years) with intraorbital lymphoma diagnosed between 1994 and 2003 were reviewed. Fifteen patients had no signs of systemic lymphoma disease. After the diagnosis of lymphoma had been surgically confirmed, chemotherapy alone was administered to seven patients, only radiotherapy was employed in nine, and both therapies were administered to five patients. With this treatment it was possible to obtain relief of orbital symptoms in 14 patients (67%) for at least 1 year. Three patients remain unchanged in their decreased visual capabilities. Local recurrence was observed in four cases and was treated with chemotherapy. Individualized microsurgical approaches to the orbit and adequate adjuvant therapy (radiotherapy, steroids, and chemotherapy, separate or in combination) are necessary to achieve satisfactory remission of orbital lymphomas.
Similar content being viewed by others
References
Ahmad S, Nutting CM, Plowman PN (2001) Orbital lymphoma treatment. Radiother Oncol 61:101
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Chen Wen B (2002) Curative radiotherapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys 54:818–823
Bolek TW, Moyses HM, Marcus RB Jr, Golden L 3rd, Maiese RL, Almasri NM, Mendenhall NP (1999) Radiotherapy in the management of orbital lymphoma. Int J Radiat Oncol Biol Phys 44:31–36
Char DH (1993) Management of orbital tumours. Mayo Clin Proc 68:1081–1096
Char DH, Ljung BM, Miller T (1988) Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. Ophthalmology 95:625–630
Davis J, Chan CC, Nussenblatt R (1992) Diagnostic vitrectomy in intermediate uveitis. In: Boke WRF, Manthey KF, Nussenblatt R (eds) Intermediate uveitis. Karger, Basel, pp 120–132
de Smet MD, Vancs VS, Kohler D, Solomon D, Chan CC (1999) Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma. Br J Ophthalmol 83:448–451
Galieni P, Polito E, Leccisotti A, Marotta G, Lasi S, Bigazzi C, Bucalossi A, Frezza G, Lauria F (1997) Localized orbital lymphoma. Haematologica 82:436–439
Geddes JF, Bhattacharjee MB, Savage K, Scaravilli F, McLaughlin JE (1992) Primary cerebral lymphoma: a study of 47 cases probed for Epstein–Barr virus genome. J Clin Pathol 45:587–590
Hassler W, Steinmetz H (1988) Surgical approaches to lesions of the optic canal and the superior orbital fissure. Contemp Neurosurg 10:1–7
Hassler W, Meyer B, Rohde V, Unsöld R (1994) Pterional approach to the contralateral orbit. Neurosurgery 34:552–554
Hejazi N, Hassler W (1997) The transconjunctival microsurgical approach to the orbit: recent experience in 22 cases. Br J Neurosurg 11:310–317
Hejazi N, Hassler W, Farghaly F (1996) Mikrochirurgischer transkonjunktivaler zugang zur orbita. Ophthalmologe 93:623–630
Jakobiec FA, Knowles DM (1989) An overview of ocular adnexal lymphoid tumours. Trans Am Ophthalmol Soc 87:420–444
Lee S, Suh CO, Kim GE, Yang WI, Lee SY, Hahn JS, Park JO (2002) Role of radiotherapy for primary orbital lymphoma. Am J Clin Oncol 25:261–265
Margo CE, Mulla ZD (1998) Malignant tumours of the orbit. Analysis of the Florida Cancer Registry. Ophthalmology 105:185–190
Nutting CM, Jenkins CD, Norton AJ, Cree I, Rose GE, Plowman PN (2002) Primary orbital lymphoma. Hematol J 3:14–16
Platanias LC, Putterman AM, Vijayakumar S, Recant W, Weichselbaum RR, Bitran JD (1992) Treatment and prognosis of orbital non-Hodgkin’s lymphomas. Am J Clin Oncol 15:79–83
Polito E, Leccisotti A (1996) Prognosis of orbital lymphoid hyperplasia. Graefes Arch Clin Exp Ophthalmol 234:150–154
Priem H, Verbraeken H, De Laey JJ (1993) Diagnostic problems in chronic vitreous inflammation. Graefes Arch Clin Exp Ophthalmol 231:453–456
Rankin GA, Jakobiec FA, Hidayat AA (1994) Intraocular lymphoproliferations simulating uveitis. In: Albert DM, Jakobiec FA (eds) Principles and practice of ophthalmology. Saunders, Philadelphia, pp 524–548
Rouwen AJP, Wijermans PW, Boen-Tan TN, Stilma JS (1989) Intraocular non-Hodgkin’s lymphoma treated with systemic and intrathecal chemotherapy and radiotherapy. A case report and review of the literature. Graefes Arch Clin Exp Ophthalmol 227:355–359
Tranfa F, Di Matteo G, Strianese D, Forte R, Bonavolonta G (2001) Primary orbital lymphoma. Orbit 20:119–124
Valluri S, Moorthy RS, Khan A, Rao NA (1995) Combination treatment of intraocular lymphoma. Retina 15:125–129
Whitcup SM, Desmet MD, Rubin BI, Palestine AG, Martin BF, Burnier M (1993) Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology 100:1399–1406
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hejazi, N. Intraorbital lymphomas: neurosurgical experiences and management strategies. Neurosurg Rev 29, 123–129 (2006). https://doi.org/10.1007/s10143-005-0008-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10143-005-0008-2