Pulmonary embolism is a life-threatening condition, which is most commonly related to deep vein thrombosis. Varicose vein thrombosis, a very common disease, is seldom reported as being related to pulmonary embolism. We present combined computed tomography venography and pulmonary angiography findings suggesting that thrombosed varicosities of a great saphenous vein caused acute pulmonary embolism in a 30-year-old male.