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Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review

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Abstract

Collagen (Col) from marine organisms has been emerging as an important alternative for commercial Col and it has been considered highly attractive by the industry. Despite the positive effects of Col from marine origin, there is still limited understanding of the effects of this natural biomaterial in the process of wound healing in animal studies. In this context, the purpose of this study was to perform a systematic review of the literature to examine the effects of Col from different marine species in the process of skin tissue healing using experimental models of skin wound. The search was carried out according to the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), and the descriptors of the Medical Subject Headings (MeSH) were defined: “marine collagen,” “spongin,” “spongin,” “skin,” and “wound.” A total of 42 articles were retrieved from the databases PubMed and Scopus. After the eligibility analyses, this review covers the different marine sources of Col reported in 10 different papers from the beginning of 2011 through the middle of 2019. The results were based mainly on histological analysis and it demonstrated that Col-based treatment resulted in a higher deposition of granulation tissue, stimulation of re-epitalization and neoangiogenesis and increased amount of Col of the wound, culminating in a more mature morphological aspect. In conclusion, this review demonstrates that marine Col from different species presented positive effects on the process of wound skin healing in experimental models used, demonstrating the huge potential of this biomaterial for tissue engineering proposals.

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Authors and Affiliations

  1. Department of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP, 11015020, Brazil

    Matheus Almeida Cruz, Tiago Akira Araujo, Ingrid Regina Avanzi, Julia Risso Parisi & Ana Claudia Muniz Rennó

  2. São Paulo State Faculty of Technology (FATEC), 350 Senador Feijó Avenue, Santos, SP, 11015502, Brazil

    Ingrid Regina Avanzi

  3. Department of Physical Therapy, Federal University of São Carlos (UFSCar), km 235 Washington Luís Road, São Carlos, SP, 13565905, Brazil

    Julia Risso Parisi, Ana Laura Martins de Andrade & Ana Claudia Muniz Rennó

Authors
  1. Matheus Almeida Cruz
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  2. Tiago Akira Araujo
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  3. Ingrid Regina Avanzi
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  4. Julia Risso Parisi
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  5. Ana Laura Martins de Andrade
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  6. Ana Claudia Muniz Rennó
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Correspondence to Ana Claudia Muniz Rennó.

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Cruz, M.A., Araujo, T.A., Avanzi, I.R. et al. Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review. Mar Biotechnol 23, 1–11 (2021). https://doi.org/10.1007/s10126-020-10011-6

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