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Enzyme Inhibitors of Marine Microbial Origin with Pharmaceutical Importance

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Abstract

Several enzyme inhibitors with various industrial uses were isolated from bacteria and actinomycetes living in the marine environment. These inhibitors are useful in medicine and agriculture. All the compounds, except the monoamine oxidase inhibitors, are novel, and their activities have been characterized.

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References

  1. J.A. Alhadeff R.T. Holzinger (1982) ArticleTitleCharacterization of β-hexosaminidase from liver and sera of diabetic patients and control. Biochem Med 27 214–225 Occurrence Handle10.1016/0006-2944(82)90024-2 Occurrence Handle1:CAS:528:DyaL38Xhsl2jsL8%3D Occurrence Handle7082325

    Article  CAS  PubMed  Google Scholar 

  2. T. Aoyagi M. Hatsu C. Imada H. Naganawa Y. Okami T. Takeuchi (1992) ArticleTitlePyrizinostatin: a new inhibitor of pyroglutamyl peptidase. J Antibiotics 45 1795–1796 Occurrence Handle1:CAS:528:DyaK3sXhs1CrsLs%3D

    CAS  Google Scholar 

  3. T. Aoyama F. Kojima C. Imada Y. Muraoka H. Naganawa Y. Okami T. Takeuchi T. Aoyagi (1995) ArticleTitlePyrostatins A and B, new inhibitors of N-acetyl-β-glucosaminidase, produced by Streptomyces sp. SA-3501. J Enzyme Inhibition 8 223–232 Occurrence Handle1:CAS:528:DyaK2MXkslWgs7Y%3D

    CAS  Google Scholar 

  4. W. Bode R. Huber (1992) ArticleTitleNatural protein proteinase inhibitors and their interaction with proteinases. Eur J Biochem 204 433–451 Occurrence Handle1:CAS:528:DyaK38XhsVKnu7c%3D Occurrence Handle1541261

    CAS  PubMed  Google Scholar 

  5. G.W. Bo-Linn C.A. Santa Ana S.G. Morawski J.S. Fordtran (1982) ArticleTitleStarch blockers—their effect on calorie absorption from a high-starch meal. N Engl J Med 307 1413–1416 Occurrence Handle1:CAS:528:DyaL3sXmsFejtg%3D%3D Occurrence Handle6182469

    CAS  PubMed  Google Scholar 

  6. F. Borges E. Fernandes F. Roleira (2002) ArticleTitleProgress towards the discovery of xanthine oxidase inhibitors. Curr Med Chem 9 195–217 Occurrence Handle1:CAS:528:DC%2BD38XhtlKlt7s%3D Occurrence Handle11860355

    CAS  PubMed  Google Scholar 

  7. H.U. Demuth (1990) ArticleTitleRecent developments in inhibiting cysteine and serine proteases. J Enzyme Inhibition 3 249–278 Occurrence Handle1:CAS:528:DyaK3cXitFSnsb0%3D

    CAS  Google Scholar 

  8. H.G. Drexler G. Gaedicke (1983) ArticleTitleIsoenzyme studies in human leukemia, III: β-hexosaminidase (E. C. 3.3.1.30). Leukemia Res 7 611–619 Occurrence Handle10.1016/0145-2126(83)90132-7 Occurrence Handle1:CAS:528:DyaL2cXjt1yrsA%3D%3D

    Article  CAS  Google Scholar 

  9. M.S. Gil-Turnes M.E. Hay W. Fenical (1989) ArticleTitleSymbiotic marine bacteria defend crustacean embryos from a pathogenic fungus. Science 240 116–118

    Google Scholar 

  10. N. Hamato R. Takano T. Kamei-Hayashi C. Imada S. Hara (1992) ArticleTitleLeupeptins produced by the marine Alteromonas sp. B-10-31. Biosci Biotech Biochem 56 1316–1318 Occurrence Handle1:CAS:528:DyaK38XmtVylsrg%3D

    CAS  Google Scholar 

  11. C. Imada U. Simidu N. Taga (1985a) ArticleTitleIsolation and characterization of marine bacteria producing alkaline protease inhibitor. Bull Jpn Soc Sci Fish 51 799–803 Occurrence Handle1:CAS:528:DyaL2MXktlClsrg%3D

    CAS  Google Scholar 

  12. C. Imada N. Taga M. Maeda (1985b) ArticleTitleCultivation conditions for subtilisin inhibitor-producing bacterium and general properties of the inhibitor “marinostatin.” Bull Jpn Soc Sci Fish 51 805–810 Occurrence Handle1:CAS:528:DyaL2MXktlClsrk%3D

    CAS  Google Scholar 

  13. C. Imada M. Maeda N. Taga (1985c) ArticleTitlePurification and characterization of the protease inhibitor “monastatin” from a marine Alteromonas sp. with reference to inhibition of the protease produced by a bacterium pathogenic to fish. Can J Microbiol 31 1089–1094 Occurrence Handle1:CAS:528:DyaL28XmsVKlsg%3D%3D

    CAS  Google Scholar 

  14. C. Imada S. Hara M. Maeda U. Simidu (1986a) ArticleTitleAmino acid sequences of marinostatins C-1 and C-2 from marine Alteromonas sp. Bull Jpn Soc Sci Fish 52 1455–1459 Occurrence Handle1:CAS:528:DyaL2sXitFKk

    CAS  Google Scholar 

  15. C. Imada M. Maeda S. Hara N. Taga U. Simidu (1986b) ArticleTitlePurification and characterization of subtilisin inhibitors “marinostatin” produced by marine Alteromonas sp. J Appl Bacteriol 60 469–476 Occurrence Handle1:CAS:528:DyaL28XlvVKmsrs%3D

    CAS  Google Scholar 

  16. C. Imada S. Nishimoto S. Hara (2001) ArticleTitleThe effect of addition of protease inhibitor from marine bacterium on the strength of gel formation of sardine meat gel (Kamaboko). Nippon Suisan Gakkaishi 67 85–89 Occurrence Handle1:CAS:528:DC%2BD3MXhtlSgsb0%3D

    CAS  Google Scholar 

  17. H. Izumida W. Miki H. Sano M. Endo (1995a) ArticleTitleAgar plate method, a new assay for chitinase inhibitors using a chitin-degrading bacterium. J Mar Biotechnol 2 163–166 Occurrence Handle1:CAS:528:DyaK2MXmvFCgtro%3D

    CAS  Google Scholar 

  18. H. Izumida K. Adachi M. Nishijima M. Endo W. Miki (1995b) ArticleTitleAkalone: a novel xanthine oxidase inhibitor produced by the marine bacterium, Agrobacterium aurantiacum sp. nov. J Mar Biotechnol 2 115–118 Occurrence Handle1:CAS:528:DyaK2MXmtFyks7Y%3D

    CAS  Google Scholar 

  19. H. Izumida N. Imamura H. Sano (1996) ArticleTitleA novel chitinase inhibitor from a marine bacterium, Pseudomonas sp. J Antibiotics 49 76–80 Occurrence Handle1:CAS:528:DyaK28Xns1SnsA%3D%3D

    CAS  Google Scholar 

  20. H. Kobori N. Taga (1980) ArticleTitleExtracellular alkaline phosphatase from marine bacteria: purification and properties of extracellular phosphatase from a marine Pseudomonas sp. Can J Microbiol 26 833–838 Occurrence Handle1:CAS:528:DyaL3cXltV2mtrc%3D

    CAS  Google Scholar 

  21. R.A. MacLeod (1968) On the role of inorganic ions in the physiology of marine bacteria, VI. M.R. Droop E.J.F. Wood (Eds) Advances in Microbiology of the Sea, Vol. 1 Academic Press New York, N.Y. 95–126

    Google Scholar 

  22. M. Maeda N. Taga (1976) ArticleTitleExtracellular nuclease produced by a marine bacterium, II: purification and properties of extracellular nuclease from a marine Vibrio sp. Can J Microbiol 22 1443–1452 Occurrence Handle1:CAS:528:DyaE28XlslehtLs%3D Occurrence Handle10061

    CAS  PubMed  Google Scholar 

  23. A. Matsuura H. Okumura R. Asakura M. Ashizawa M. Takahashi F. Kobayashi N. Ashikawa K. Arai (1993) ArticleTitlePharmacological profiles of aspergillomarasmines as endothelin converting enzyme inhibitors. Jpn J Pharmacol 63 187–193 Occurrence Handle1:CAS:528:DyaK2cXitlGisQ%3D%3D Occurrence Handle8283829

    CAS  PubMed  Google Scholar 

  24. A. Ogata N. Hamaue M. Terado M. Minami K. Nagashima K. Tashiro (2003) ArticleTitleIsatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson’s disease induced by Japanese encephalitis virus. J Neurol Sci 206 79–83 Occurrence Handle10.1016/S0022-510X(02)00342-8 Occurrence Handle1:CAS:528:DC%2BD38XptlCqtrY%3D Occurrence Handle12480089

    Article  CAS  PubMed  Google Scholar 

  25. M.C. Pluncinsky J.J. Prorok J.A. Alhadeff (1986) ArticleTitleVariant serum β-hexosaminidase as a biochemical marker of malignancy. Cancer 58 1484–1487 Occurrence Handle2943402

    PubMed  Google Scholar 

  26. C.A. Prasad A. Peterkofsky (1976) ArticleTitleDetermination of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts. J Biol Chem 251 3229–3234 Occurrence Handle1:CAS:528:DyaE28XksVCitr8%3D Occurrence Handle819429

    CAS  PubMed  Google Scholar 

  27. W. Puls U. Keup (1973) ArticleTitleInfluence of an α-amylase inhibitor (BAY d 7791) on blood glucose, serum insulin and NEFA in starch loading tests in rats, dogs and man. Diabetologia 9 97–101 Occurrence Handle1:CAS:528:DyaE3sXktlyluro%3D Occurrence Handle4716119

    CAS  PubMed  Google Scholar 

  28. S. Sakuda A. Isogai S. Matsumoto A. Suzuki (1986) ArticleTitleThe structure of allosamidine, a novel insect chitinase inhibitor produced by Streptomyces sp. Tetrahedron Lett 27 2475–2478 Occurrence Handle10.1016/S0040-4039(00)84560-8 Occurrence Handle1:CAS:528:DyaL28XkvFCiurs%3D

    Article  CAS  Google Scholar 

  29. K.D. Spindler M. Spindler-Barth M. Londershausen (1990) ArticleTitleChitin metabolism: a target for drugs against parasites. Parasitol Res 76 283–288 Occurrence Handle1:STN:280:By%2BB2crotlc%3D Occurrence Handle2186405

    CAS  PubMed  Google Scholar 

  30. H. Sugino A. Kakinuma (1978) ArticleTitlePlasminostreptin, a protein proteinase inhibitor produced by Streptomyces antifibrinolyticus, III: elucidation of the primary structure. J Biol Chem 253 1546–1555 Occurrence Handle1:CAS:528:DyaE1cXhtlamtbw%3D Occurrence Handle627554

    CAS  PubMed  Google Scholar 

  31. A. Szewcruk J. Kwiatkowska (1970) ArticleTitlePyrrolidonyl peptidase in animal, plant and human tissues. Eur J Biochem 15 92–96 Occurrence Handle5489840

    PubMed  Google Scholar 

  32. S. Takaishi N. Tuchiya A. Sato T. Negishi Y. Takamatsu Y. Matsushita T. Watanabe Y. Iijima H. Haruyama T. Kinoshita M. Tanaka K. Kodama (1998) ArticleTitleB-90063, a novel endothelin converting enzyme inhibitor isolated from a new marine bacterium, Blastobacter sp. SANK 71894. J Antibiotics 51 805–815 Occurrence Handle1:CAS:528:DyaK1cXmsVCqt74%3D

    CAS  Google Scholar 

  33. T. Terashita M. Kono S. Murao (1980) ArticleTitlePromoting effect of S-PI on fruiting of Lentinus edodes. Trans Mycol Soc Jpn 21 137–140 Occurrence Handle1:CAS:528:DyaL3cXltVyru7o%3D

    CAS  Google Scholar 

  34. D. Tsuru K. Fujiwara K. Kado (1978) ArticleTitlePurification and characterization of L-pyrrolidonecarboxylate peptidase from Bacillus amloliquefaciens. J Biochem 84 467–476 Occurrence Handle1:CAS:528:DyaE1cXlsF2htL8%3D Occurrence Handle29893

    CAS  PubMed  Google Scholar 

  35. Y. Tsurumi N. Ohhata T. Iwamoto N. Shigematsu K. Sakamoto M. Nishikawa S. Kiyoto M. Okuhara (1994) ArticleTitleWS79089A, B, and C, new endothelin converting enzyme inhibitors isolated from Stretosporangium roseum, No. 79089: taxonomy, fermentation, isolation, physicochemical properties and biological activities. J Antibiotics 47 619–629 Occurrence Handle1:CAS:528:DyaK2cXlt12msb4%3D

    CAS  Google Scholar 

  36. H. Umezawa (1972) Enzyme Inhibitor of Microbial Origin University of Tokyo Press Tokyo, Japan

    Google Scholar 

  37. H. Umezawa T. Aoyagi H. Morishima M. Matsuzaki M. Hamada T. Takeuchi (1970) ArticleTitlePepstatin, a new pepsin inhibitor produced by actinomycetes. J Antibiotics 23 259–262 Occurrence Handle1:CAS:528:DyaE3cXksFCnsL0%3D

    CAS  Google Scholar 

  38. D.M.F. Aalten Particlevan D. Komander B. Systad S. Gaseidnes M.G. Peter V.G.H. Eijsink (2001) ArticleTitleStructural insights into the catalytic mechanism of a family 18 exo-chitinase. Proc Natl Acad Sci U S A 98 8979–8984 Occurrence Handle10.1073/pnas.151103798 Occurrence Handle11481469

    Article  PubMed  Google Scholar 

  39. K. Yamazaki H. Hasegawa K. Umekawa Y. Ueki N. Ohashi M. Kanaoka (2002) ArticleTitleDesign, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues. Bioorg Med Chem Lett 12 1275–1278 Occurrence Handle10.1016/S0960-894X(02)00149-X Occurrence Handle1:CAS:528:DC%2BD38XivVOrs7w%3D Occurrence Handle11965369

    Article  CAS  PubMed  Google Scholar 

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  1. Tokyo University of Marine Science and Technology, 108-8477, Minato, Tokyo, Japan

    Chiaki Imada

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  1. Chiaki Imada
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Correspondence to Chiaki Imada.

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Imada, C. Enzyme Inhibitors of Marine Microbial Origin with Pharmaceutical Importance. Mar. Biotechnol. 6, 193–198 (2004). https://doi.org/10.1007/s10126-003-0027-3

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