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Marine Pharmacology in 2000: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiplatelet, Antituberculosis, and Antiviral Activities; Affecting the Cardiovascular, Immune, and Nervous Systems and Other Miscellaneous Mechanisms of Action

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Abstract

During 2000 research on the pharmacology of marine chemicals involved investigators from Australia, Brazil, Canada, Egypt, France, Germany, India, Indonesia, Israel, Italy, Japan, the Netherlands, New Zealand, Phillipines, Singapore, Slovenia, South Korea, Spain, Sweden, Switzerland, United Kingdom, and the United States. This current review, a sequel to the authors’ 1998 and 1999 reviews, classifies 68 peer-reviewed articles on the basis of the reported preclinical pharmacologic properties of marine chemicals derived from a diverse group of marine animals, algae, fungi, and bacteria. Antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis, or antiviral activity was reported for 35 marine chemicals. An additional 20 marine compounds were shown to have significant effects on the cardiovascular and nervous system, and to possess anti-inflammatory or immunosuppressant properties. Finally, 23 marine compounds were reported to act on a variety of molecular targets and thus could potentially contribute to several pharmacologic classes. Thus, as in 1998 and 1999, during 2000 pharmacologic research with marine chemicals continued to contribute potentially novel chemical leads to the ongoing global search for therapeutic agents in the treatment of multiple disease categories.

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Acknowledgements

This publication was made possible with support from the National Institutes of Health (R03 ES10138-01 to A.M.S.M.) and (1R01A136596, 5K02A101502 to M.T.H.) and UNDP/World Bank/WHO special Program for Research and Training in Tropical Diseases (TDR 990199 to M.T.H.) and Midwestern University. Its content is solely the responsibility of the authors and does not necessarily represent the official view of the NIEHS, NIH. Jennifer Allman and Shelley Fleming are gratefully acknowledged for their assistance with the preparation of figures. Excellent support for literature searches and article retrieval by library staff members as well as medical and pharmacy students of Midwestern University is most gratefully acknowledged. The authors specially thank Mrs. Victoria Sears and Ms. Mary Hall for their assistance in the preparation of this manuscript.

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  1. Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA

    Alejandro M. S. Mayer

  2. School of Pharmacy, University of Mississippi, 125 Old Chemistry, University, MS 38677, USA

    Mark T. Hamann

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Correspondence to Alejandro M. S. Mayer.

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Mayer, A.M., Hamann, M.T. Marine Pharmacology in 2000: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiplatelet, Antituberculosis, and Antiviral Activities; Affecting the Cardiovascular, Immune, and Nervous Systems and Other Miscellaneous Mechanisms of Action . Mar. Biotechnol. 6, 37–52 (2004). https://doi.org/10.1007/s10126-003-0007-7

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