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Identification of Antihypertensive Peptides from Peptic Digest of Two Microalgae, Chlorella vulgaris and Spirulina platensis

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Abstract:

The peptidic fractions that inhibited angiotensin I–converting enzyme (ACE) were separated from the peptic digests of 2 microalgae, Chlorella vulgaris and Spirulina platensis, by ion exchange chromatography and gel filtration. Oral administration of peptidic fractions into spontaneously hypertensive rats at 200 mg/kg of body weight resulted in marked antihypertensive effects. Further separation of the peptidic fractions by ODS high-performance liquid chromatography furnished the following active peptides: Ile-Val-Val-Glu (inhibitory against ACE with an IC50 of 315.3 μM), Ala-Phe-Leu (63.8 μM), Phe-Ala-Leu (26.3 μM), Ala-Glu-Leu (57.1 μM), and Val-Val-Pro-Pro-Ala (79.5 μM) from C. vulgaris; Ile-Ala-Glu (34.7 μM), Phe-Ala-Leu, Ala-Glu-Leu, Ile-Ala-Pro-Gly (11.4 μM), and Val-Ala-Phe (35.8 μM) from S. platensis.

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Authors and Affiliations

  1. Department of Food Science and Technology, National Fisheries University, 2-7-1 Nagata Honmachi, Shimonoseki, Yamaguchi 759-6595, Japan, , , , , , JP

    Kunio Suetsuna

  2. School of Nutrition and Health Science, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan, , , , , , TW

    Jiun-Rong Chen

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  1. Kunio Suetsuna
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  2. Jiun-Rong Chen
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Received July 7, 2000; accepted January 15, 2001

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Suetsuna, K., Chen, JR. Identification of Antihypertensive Peptides from Peptic Digest of Two Microalgae, Chlorella vulgaris and Spirulina platensis . Mar. Biotechnol. 3, 305–309 (2001). https://doi.org/10.1007/s10126-001-0012-7

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  • DOI: https://doi.org/10.1007/s10126-001-0012-7

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