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Actinobacteria—a promising natural source of anti-biofilm agents

International Microbiology volume 22, pages 403–409 (2019)Cite this article

Abstract

A biofilm is a community of microorganisms attached to a surface and embedded in a matrix of extracellular polymeric substances. Biofilms confer resistance towards conventional antibiotic treatments; thus, there is an urgent need for newer and more effective antimicrobial agents that can act against these biofilms. Due to this situation, various studies have been done to investigate the anti-biofilm effects of natural products including bioactive compounds extracted from microorganisms such as Actinobacteria. This review provides an insight into the anti-biofilm potential of Actinobacteria against various pathogenic bacteria, which hopefully provides useful information, guidance, and improvements for future antimicrobial studies. Nevertheless, further research on the anti-biofilm mechanisms and compound modifications to produce more potent anti-biofilm effects are required.

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Funding

This work was supported by the grant from Yayasan Pahang (GA004-2018) awarded to Dr. Adzzie Shazleen Azman.

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Affiliations

  1. Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Adzzie-Shazleen Azman & Sazaly AbuBakar

  2. School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia

    Christina-Injan Mawang

  3. Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

    Jasmine-Elanie Khairat

  4. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Sazaly AbuBakar

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  1. Adzzie-Shazleen Azman
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  2. Christina-Injan Mawang
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  3. Jasmine-Elanie Khairat
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  4. Sazaly AbuBakar
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Correspondence to Adzzie-Shazleen Azman or Sazaly AbuBakar.

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Azman, AS., Mawang, CI., Khairat, JE. et al. Actinobacteria—a promising natural source of anti-biofilm agents. Int Microbiol 22, 403–409 (2019). https://doi.org/10.1007/s10123-019-00066-4

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  • DOI: https://doi.org/10.1007/s10123-019-00066-4

Keywords

  • Streptomyces
  • Non-Streptomyces
  • Actinobacteria
  • Anti-biofilm
  • Biofilms