Utility of continuous glucose monitoring following gastrectomy



Glucose fluctuation after gastrectomy represented by dumping syndrome is a well-known post-gastrectomy syndrome that negatively impacts patient quality of life. However, the current methods of post-gastrectomy glucose monitoring do not comprehensively capture the postoperative blood glucose fluctuations that characterize this.


We used a continuous glucose monitoring (CGM) system to document the glycemic profiles of patients undergoing gastrectomy and compared these between patients undergoing distal gastrectomy (DG) and total gastrectomy (TG). To evaluate post-gastrectomy syndromes, including dumping syndrome, we used the Post-gastrectomy Syndrome Assessment Scale 37-item questionnaire. The glycemic profiles were also compared using this tool.


We studied 57 patients who had undergone DG and 13 who had undergone TG between September 2017 and September 2019. Our results revealed larger diurnal glycemic variability and longer periods of nocturnal hypoglycemia after gastrectomy. The dumping score was worse in the TG than in the DG group (TG 2.4 ± 1.4 vs. DG 1.3 ± 1.2, P = 0.0061). Importantly, 30 of 57 DG patients (52.6%) and 5 of 13 TG patients (38.5%) experienced postprandial hypoglycemia following hyperglycemia without hypoglycemic symptoms. There was no correlation between the dumping symptom score and glycemic variability (ρ = 0.0545, P = 0.6662).


CGM demonstrated diurnal glycemic variability and nocturnal hypoglycemia in patients undergoing gastrectomy. Because some hypoglycemic patients did not develop symptoms and glycemic variability was not necessarily associated with dumping symptom, dumping syndrome must only partially explain the postoperative glucose fluctuations.

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This work was supported in part by a Grant-in Aid for Scientific Research, No 18H02882. We thank Mark Cleasby from Edanz Group (www.edanzediting.com/ac) for editing drafts of this manuscript.

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Correspondence to Takeshi Kubota.

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The authors declare that they have no conflicts of interest.

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This study conformed to the ethical guidelines of the World Medical Association Declaration of Helsinki. All patients gave their written informed consent for surgery and the use of clinical data, as required by the Institutional Review Board of the Kyoto Prefectural University of Medicine (ERB-C-975–2).

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Kubota, T., Shoda, K., Ushigome, E. et al. Utility of continuous glucose monitoring following gastrectomy. Gastric Cancer 23, 699–706 (2020). https://doi.org/10.1007/s10120-019-01036-5

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  • Gastric cancer
  • Gastrectomy
  • Continuous glucose monitoring
  • Glycemic variability
  • Dumping syndrome