Gastric Cancer

, Volume 21, Issue 4, pp 579–587 | Cite as

The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis

  • Yue Hu 
  • Shan Liu 
  • Bin Lv 
Review Article



Despite extensive research on the criteria for the assessment of gastric cancer risk using the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis/Intestinal-Metaplasia Assessment (OLGIM) systems, no comprehensive overview or systematic summary on their use is currently available.


To perform a systematic review and meta-analysis to assess the efficacy of the OLGA and OLGIM staging systems in evaluating gastric cancer risk.


We searched various databases, including PubMed, EMBASE, Medline, and Cochrane’s library, for articles published before March 2017 on the association between OLGA/OLGIM stages and risk of gastric cancer. Statistical analysis was performed using RevMan 5.30 and Stata 14.0, with the odds ratio, risk ratio, and 95% confidence interval as the effect measures.


A meta-analysis of six case–control studies and two cohort studies, comprising 2700 subjects, was performed. The meta-analysis of prospective case–control studies demonstrated a significant association between the OLGA/OLGIM stages III/IV and gastric cancer. The Newcastle–Ottawa Scale (NOS) score reflected heterogeneity in the case–control studies on OLGA. Subgroup analysis of high-quality (NOS score ≥ 5) studies showed an association between OLGA stage III/IV and increased risk of gastric cancer; the association was also high in the remaining study with low NOS score. The association between higher stages of gastritis defined by OLGA and risk of gastric cancer was significant.


This correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.


Gastric cancer Operative link on gastritis assessment Operative link on gastric intestinal metaplasia assessment stage Risk factors Meta-analysis Systematic review 



This study was funded by Natural Science Foundation of China (NSFC) (Grant numbers 81700468 and 81770535).

Ethical approval

No ethical approval or informed consent statement was required for this review article.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10120_2018_812_MOESM1_ESM.docx (13.5 mb)
Supplementary material 1 (DOCX 13.5 MB)


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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2018

Authors and Affiliations

  1. 1.Department of Gastroenterology, First Affiliated Hospital of ZhejiangChinese Medical UniversityHangzhouChina
  2. 2.Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of ZhejiangChinese Medical UniversityHangzhouChina

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