Abstract
Background
The aberrant expression of activation-induced cytidine deaminase (AICDA) was reportedly induced in gastric epithelial cells infected with cytotoxin-associated gene A (cagA)-positive Helicobacter pylori, resulting in the accumulation of alterations in the TP53 tumor suppressor gene in gastric cells. We investigated the association of the AICDA 7888 C/T polymorphism with H. pylori infection and the risk of gastric cancer and atrophic gastritis in Japanese subjects.
Methods
The study subjects were 583 histologically diagnosed gastric cancer patients (cases) and 1637 age- and sexfrequency-matched control outpatients, who visited Aichi Cancer Center Hospital from the years 2001 to 2005. In the controls, serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and atrophic gastritis, respectively. Odds ratios (ORs) and 95% confi dence intervals (CIs) were calculated by a logistic model.
Results
H. pylori seropositivity in the controls was not signifi cantly associated with the AICDA 7888 C/T genotypes. Among the H. pylori seropositive control subjects, the ageand sex-adjusted ORs of atrophic gastritis were not statistically signifi cant: 0.84 (95% CI, 0.62–1.13) for C/T, 0.82 (95% CI, 0.56–1.21) for T/T, and 0.83 (95% CI, 0.63–1.11) for C/T+T/T, relative to the C/C genotype. The age- and sexadjusted ORs of gastric cancer relative to atrophic gastritis were also not statistically signifi cant, at 1.17 (95% CI 0.89–1.54), 1.21 (95% CI, 0.85–1.71), and 1.18 (95% CI, 0.91–1.53), respectively. The OR of gastric cancer cases compared with the whole cohort of control subjects was also not signifi cant.
Conclusion
The hypothetical association of the AICDA 7888 C/T polymorphism with the risk of gastric cancer or gastric atrophy was not shown in this study.
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Hishida, A., Matsuo, K., Goto, Y. et al. No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. Gastric Cancer 13, 43–49 (2010). https://doi.org/10.1007/s10120-009-0534-7
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DOI: https://doi.org/10.1007/s10120-009-0534-7