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Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake

Gastric Cancer volume 12, pages 225–228 (2009)Cite this article

Abstract

This is the first case of gastric schwannoma that exhibited increased accumulation of [(18)F] fluorodeoxyglucose (FDG) on positron emission tomography (PET) imaging. The patient was a 60-year-old woman in whom esophagogastroduodenoscopy showed a submucosal tumor, about 25 mm in size, in the upper body of the stomach, with ulceration at the top of the tumor. Endoscopic ultrasonography revealed a well-defined hypoechoic mass located in the proper muscle layer of the stomach. The specimen taken from the tumor showed only inflammatory degenerative tissue. Abdominal computed tomography revealed a tumor in the upper body of the stomach. FDG-PET showed FDG uptake (standardized uptake value [SUV] max 5.8) coincident with the tumor. Hence, the tumor was diagnosed initially as a gastrointestinal stromal tumor of the stomach. Laparoscopic partial gastrectomy was performed. Pathological examination showed that the tumor consisted of spindle cells with large nuclei, and mitosis was absent. The Ki-67 labeling index of the tumor cells was 4%. Immunohistochemically, the tumor cells showed a positive reaction for S-100 protein, whereas they were negative for KIT, CD 34, and alpha-smooth muscle actin protein. The tumor was diagnosed as a benign gastric schwannoma. Gastric schwannoma should be included in the differential diagnosis of submucosal tumors of the stomach with FDG uptake.

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Affiliations

  1. Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Daisuke Komatsu, Naohiko Koide, Risako Hiraga & Shinichi Miyagawa

  2. Department of Internal Medicine, Hotaka Hospital, Azumino, Nagano, Japan

    Naoyuki Furuya

  3. Department of Endoscopy, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

    Taiji Akamatsu

  4. Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

    Takeshi Uehara

Authors
  1. Daisuke Komatsu
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  2. Naohiko Koide
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  3. Risako Hiraga
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  4. Naoyuki Furuya
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  5. Taiji Akamatsu
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  6. Takeshi Uehara
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  7. Shinichi Miyagawa
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Komatsu, D., Koide, N., Hiraga, R. et al. Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake. Gastric Cancer 12, 225–228 (2009). https://doi.org/10.1007/s10120-009-0526-7

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  • DOI: https://doi.org/10.1007/s10120-009-0526-7

Key words

  • Schwannoma
  • Stomach
  • Fluorodeoxyglucose
  • Positron emission tomography