Abstract
Background
It has been proved that some differentiated-type gastric carcinomas have a gastric phenotype. Similarly, it can be conjectured that some undifferentiated-type gastric carcinomas have an intestinal phenotype and that there are biological differences between undifferentiated-type gastric carcinomas with a gastric phenotype and those with an intestinal phenotype. We classified the phenotypes of early undifferentiated-type gastric carcinomas and investigated the relationship between their biological behavior and the phenotypes.
Methods
Sixty lesions of intramucosal undifferentiated-type gastric carcinoma were classified into four phenotypes; gastric type, incomplete-intestinal type, complete-intestinal type, and unclassified type, according to the expression of CD10, MUC2, small-intestinal mucinous antigen (SIMA), human gastric mucin (HGM), or concanavalin A (ConA).
Results
The incidence of gastric-type carcinoma, incomplete-intestinal-type carcinoma, and complete-intestinal-type carcinoma was 33% (20 cases), 65% (39 cases), and 2% (1 case), respectively. There was no significant difference in any of the clinicopathological factors examined between the 20 gastric-type carcinomas and the 40 intestinal-type carcinomas, but there were significant differences in the morphological findings. Intestinal-type carcinomas had a glandular structure more frequently than the gastric-type carcinomas. The spreading pattern of gastric-type carcinomas showed a middle-layer type more frequently than the intestinal-type carcinomas.
Conclusion
Undifferentiated-type gastric carcinomas frequently expressed an intestinal phenotype. There were differences in the growth patterns between undifferentiated-type gastric carcinomas with a gastric phenotype and those with the intestinal phenotype.
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References
P Lauren (1965) ArticleTitleThe two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma Acta Pathol Microbiol Immunol Scand 64 31–49 Occurrence Handle1:STN:280:CCqC38rjsVw%3D
K Nakamura H Sugano K Takagi (1968) ArticleTitleCarcinoma of stomach in incipient phase: its histogenesis and histological appearances GANN 59 251–8 Occurrence Handle5726267 Occurrence Handle1:STN:280:CCaD287ps1U%3D
M Tatematsu M Ichinose K Miki R Hasegawa T Kato N Ito (1990) ArticleTitleGastric intestinal phenotypic expression of human stomach cancers as revealed by peptinogen immunohistochemistry and mucin histochemistry Acta Pathol Jpn 40 494–504 Occurrence Handle2220396 Occurrence Handle1:STN:280:By6D383gt1w%3D
Y Egashira (1994) ArticleTitleMucin histochemical study of differentiated adenocarcinoma of stomach Jpn J Gastroenterol 91 839–48 Occurrence Handle1:STN:280:ByuB38znvFY%3D
A Kabashima T Yao M Tsuneyoshi (2000) ArticleTitleGastric and intestinal phenotypic expression in the carcinomas and background mucosa of multiple early gastric carcinomas Histopathology 37 513–22 Occurrence Handle10.1046/j.1365-2559.2000.01008.x Occurrence Handle11122433 Occurrence Handle1:STN:280:DC%2BD3M7hvFWiug%3D%3D
T Yoshino T Shimoda A Saitou Y Nakanishi Y Tajima T Shirasu et al. (1999) ArticleTitleMacroscopic features of differentiated gastric adenocarcinoma with gastric or intestinal phenotype expression in early gastric cancer I to Cho (Stomach and Intestine) 34 507–25
K Kubo A Yanagisawa Y Ninomiya N Inoshita Y Kato (1999) ArticleTitleCharacteristics of differentiated-type carcinoma with gastric phenotype of the stomach I to Cho (Stomach and Intestine) 34 487–94
K Koseki T Takizawa M Koike N Funata T Hishima R Sakoma et al. (1999) ArticleTitleSubclassification of well differentiated gastric cancer with reference to biological behavior and malignancy, gastric type vs intestinal type, and papillary carcinoma vs tubular carcinoma I to Cho (Stomach and Intestine) 34 507–12
K Nishikura H Watanabe Y Ninomiya Y Ajioka H Hashidate et al. (1999) ArticleTitleDifferentiated gastric adenocarcinoma with gastric phenotype. Its new classification and histopathological characteristics I to Cho (Stomach and Intestine) 34 495–506
Y Endou G Tamura K Sakata K Oomura H Watanabe T Motoyama (1999) ArticleTitleGenetic analysis of differentiated-type adenocarcinomas of the stomach with gastric phenotype and intestinal phenotype I to Cho (Stomach and Intestine) 34 539–44
M Oya T Yao M Tsuneyoshi (1997) ArticleTitleA correlation of intramural invasion with mucin histochemistry, and immunohistochemical expressions of oncogene-related proteins in early gastric carcinoma I to Cho (Stomach and Intestine) 32 31–9
R Fiocca L Villani P Tenti M Cornaggia D Finzi C Capella et al. (1988) ArticleTitleWidespread expression of intestinal markers in gastric carcinoma: a light and electron microscopic study using BD-5 monoclonal antibody J Clin Pathol 41 178–87 Occurrence Handle3350978 Occurrence Handle1:STN:280:BieC2s%2FgvVY%3D
R Fiocca L Villani P Tenti M Cornaggia D Finzi C Riva et al. (1990) ArticleTitleThe foveolar cell component of gastric cancer Hum Pathol 21 260–70 Occurrence Handle2312104 Occurrence Handle1:STN:280:By%2BC1crmsFU%3D
R Fiocca L Villani P Tenti M Cornaggia B Frigerio E Solcia et al. (1987) ArticleTitleCharacterization of four main cell types in gastric cancer: foveolar, mucopeptic, intestinal columnar and goblet cells Pathol Res Pract 182 308–25 Occurrence Handle3628092 Occurrence Handle1:STN:280:BiiA3MjisVw%3D
T Yamachika K Inada Y Fujimitu S Nakamura Y Yamamura T Kitou et al. (1997) ArticleTitleIntestinalization of gastric signet ring cell carcinomas with progression Virchows Arch 431 103–10 Occurrence Handle9293891 Occurrence Handle1:STN:280:ByiH3sfhtFI%3D
T Yao M Kajiwara S Kuroiwa A Iwashita M Oya A Kabashima et al. (2002) ArticleTitleMalignant transformation of gastric hyperplastic polyps: alteration phenotypes, proliferative activity, and p53 expression Hum Pathol 33 1016–22 Occurrence Handle10.1053/hupa.2002.126874 Occurrence Handle12395375 Occurrence Handle1:CAS:528:DC%2BD38Xosl2qsLY%3D
InstitutionalAuthorNameJapanese Research Society for Gastric Cancer (1993) The general rules for gastric cancer study EditionNumber12th ed. Kinbara Tokyo
T Yao A Kabashima T Kouzuki M Oya M Tsuneyoshi (1999) ArticleTitleThe phenotypes of the gastric carcinoma. Evaluation by a new immunohistochemical method I to Cho (Stomach and Intestine) 34 477–85
EM Danielsen JP Vyas AJ Kenny (1980) ArticleTitleA neutral endopeptidase in the microvillar membrane of pig intestine Biochem J 191 645–8 Occurrence Handle7016112 Occurrence Handle1:CAS:528:DyaL3MXnvFSltA%3D%3D
LK Trejdosiewicz G Malizia J Oakes MS Losowsky G Janossy (1985) ArticleTitleExpression of the common acute lymphoblastic leukemia antigen in the brush border of normal jejunum and jejunum of patients with coeliac disease J Clin Pathol 38 1002–6 Occurrence Handle2931454 Occurrence Handle1:STN:280:BimD3cfpslI%3D
Y Endoh G Tamura T Motoyama Y Ajioka H Watanabe (1999) ArticleTitleWell-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach Hum Pathol 30 826–32 Occurrence Handle10.1016/S0046-8177(99)90144-2 Occurrence Handle10414502 Occurrence Handle1:STN:280:DyaK1MzktFCmsA%3D%3D
KMAJ Tytgat HA Buller FJM Opdam (1994) ArticleTitleBiosynthesis of human colon mucin: MUC2 is prominent secretory mucin Gasteroenterology 107 1352–63 Occurrence Handle1:CAS:528:DyaK2MXitlGmsLg%3D
Y Ajioka H Watanabe JR Jass (1997) ArticleTitleMUC1 and MUC2 mucin in flat and polypoid colorectal adenomas J Clin Pathol 50 417–21 Occurrence Handle9215126 Occurrence Handle1:STN:280:ByiA2MjpsVE%3D
Y Ajioka LJ Allison JR Jass (1996) ArticleTitleSignificance of MUC1 and MUC2 mucin expression in colorectal cancer J Clin Pathol 49 560–4 Occurrence Handle8813954 Occurrence Handle1:STN:280:BymH3cfpslU%3D
J Bara R Gautier H Zaghouani C Decaens N Daher (1986) ArticleTitleMonoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosae Cancer Res 46 3983–9 Occurrence Handle3524800 Occurrence Handle1:CAS:528:DyaL28XltFehsbw%3D
J Bara R Gautier P Mouradian C Decaens N Daher (1991) ArticleTitleOncofetal mucin M1 epitope family: characterization and expression during colonic carcinogenesis Int J Cancer 47 304–10 Occurrence Handle1988372 Occurrence Handle1:CAS:528:DyaK3MXhvVent7c%3D
PJ Hertzog HC Robinson J Ma IR Mackay AW Linnane (1991) ArticleTitleOncofetal expression of the human intestinal mucin glycoprotein antigens in gastrointestinal epithelium defined by monoclonal antibodies Int J Cancer 48 355–63 Occurrence Handle1710206 Occurrence Handle1:CAS:528:DyaK3MXlsFKmu78%3D
PJ Hertzog HC Robinson J Ma IR Mackay AW Linnane (1992) ArticleTitleOncofetal expression of the human intestinal mucin glycoprotein antigens in gastrointestinal epithelium defined by monoclonal antibodies. Int J Cancer early appearance of a hierarchy of small intestinal mucin antigen (SIMA) epitopes and correlation with malignant potential Br J Cancer 66 748–57 Occurrence Handle1419617
SJ Pilbrow PJ Hertzog AW Linnane (1993) ArticleTitleDifferentiation-associated changes in mucin glycoprotein antigenicity in mucosa adjacent to rare gastrointestinal tract tumors of non-mucosal origin J Pathol 169 259–67 Occurrence Handle8445491 Occurrence Handle1:STN:280:ByyC1cjns1I%3D
GD Pinczower RPW Williams RD Gianello HC Robinson BN Preston AW Linnane (1996) ArticleTitleCharacterisation of the tumor-associated carbohydrate epitope recognized by monoclonal antibody 4D3 Int J Cancer 66 636–44 Occurrence Handle10.1002/(SICI)1097-0215(19960529)66:5<636::AID-IJC10>3.0.CO;2-2 Occurrence Handle8647626 Occurrence Handle1:CAS:528:DyaK28XktFynuro%3D
AR Sepulveda L Wu H Ota O Gutierrrez JG Kim RM Genta et al. (2000) ArticleTitleMolecular identification of main cellular lineages as a tool for the classification of gastric cancer Hum Pathol 31 566–74 Occurrence Handle10.1053/hp.2000.6684 Occurrence Handle10836295 Occurrence Handle1:CAS:528:DC%2BD3cXjvFShtL0%3D
Y Fujimori T Akamatsu H Ota T Katsuyama (1995) ArticleTitleProliferative markers in gastric carcinoma and organoid differentiation Hum Pathol 26 725–34 Occurrence Handle10.1016/0046-8177(95)90219-8 Occurrence Handle7628843 Occurrence Handle1:STN:280:ByqA2MrhtFc%3D
YZ Wang H Mitomi M Kurihara K Ishihara K Hotta H Tanigawa et al. (2000) ArticleTitleGastric adenomas and superficial adenocarcinomas display distinct patterns of mucin carbohydrate and core protein expression Histopathology 37 250–9 Occurrence Handle10971701 Occurrence Handle1:STN:280:DC%2BD3cvnt1Clsg%3D%3D
T Akamatsu T Katsuyama (1990) ArticleTitleHistochemical demonstration of mucins in the intramucosal laminated structure of human gastric signet ring carcinoma and its relation to submucosal invasion Histochem J 22 416–25 Occurrence Handle10.1007/BF01003461 Occurrence Handle2172192 Occurrence Handle1:STN:280:By6D3svos10%3D
H Sugihara T Hattori M Fukuda S Fujita (1987) ArticleTitleCell proliferation and differentiation in intramucosal and advanced signet ring cell carcinomas of human stomach Virchows Arch A 411 117–27 Occurrence Handle10.1007/BF00712735 Occurrence Handle1:STN:280:BiiB28rktlI%3D
E Solcia R Fiocca O Luinetti L Villani L Padovan D Calistri et al. (1996) ArticleTitleIntestinal and diffuse gastric cancers arise in a different background of Helicobacter pylori gastritis through different gene involvement AJSP 20 8–22
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Kabashima, A., Yao, T., Maehara, Y. et al. Relationship between biological behavior and phenotypic expression in undifferentiated-type gastric carcinomas. Gastric Cancer 8, 220–227 (2005). https://doi.org/10.1007/s10120-005-0340-9
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DOI: https://doi.org/10.1007/s10120-005-0340-9