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Gastric Cancer

, Volume 8, Issue 4, pp 220–227 | Cite as

Relationship between biological behavior and phenotypic expression in undifferentiated-type gastric carcinomas

  • Akira Kabashima
  • Takashi Yao
  • Yoshihiko Maehara
  • Masazumi Tsuneyoshi
Original article

Abstract

Background

It has been proved that some differentiated-type gastric carcinomas have a gastric phenotype. Similarly, it can be conjectured that some undifferentiated-type gastric carcinomas have an intestinal phenotype and that there are biological differences between undifferentiated-type gastric carcinomas with a gastric phenotype and those with an intestinal phenotype. We classified the phenotypes of early undifferentiated-type gastric carcinomas and investigated the relationship between their biological behavior and the phenotypes.

Methods

Sixty lesions of intramucosal undifferentiated-type gastric carcinoma were classified into four phenotypes; gastric type, incomplete-intestinal type, complete-intestinal type, and unclassified type, according to the expression of CD10, MUC2, small-intestinal mucinous antigen (SIMA), human gastric mucin (HGM), or concanavalin A (ConA).

Results

The incidence of gastric-type carcinoma, incomplete-intestinal-type carcinoma, and complete-intestinal-type carcinoma was 33% (20 cases), 65% (39 cases), and 2% (1 case), respectively. There was no significant difference in any of the clinicopathological factors examined between the 20 gastric-type carcinomas and the 40 intestinal-type carcinomas, but there were significant differences in the morphological findings. Intestinal-type carcinomas had a glandular structure more frequently than the gastric-type carcinomas. The spreading pattern of gastric-type carcinomas showed a middle-layer type more frequently than the intestinal-type carcinomas.

Conclusion

Undifferentiated-type gastric carcinomas frequently expressed an intestinal phenotype. There were differences in the growth patterns between undifferentiated-type gastric carcinomas with a gastric phenotype and those with the intestinal phenotype.

Key words

Phenotypic expression Undifferentiated-type gastric carcinomas Growth pattern 

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Copyright information

© International and Japanese Gastric Cancer Association 2005

Authors and Affiliations

  • Akira Kabashima
    • 1
    • 2
  • Takashi Yao
    • 1
  • Yoshihiko Maehara
    • 2
  • Masazumi Tsuneyoshi
    • 1
  1. 1.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Surgery and Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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