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Gastric Cancer

, Volume 6, Issue 2, pp 100–107 | Cite as

Helicobacter pylori eradication therapy for the remnant stomach after gastrectomy

  • Norio Matsukura
  • Takashi Tajiri
  • Shunji Kato
  • Akiyoshi Togashi
  • Gotaro Masuda
  • Itsuo Fujita
  • Akira Tokunaga
  • Nobutaka Yamada
Original article
  • 344 Downloads

Background.

The remnant stomach after surgery for gastric cancer is at high risk for the metachronous development of multiple gastric cancers. Here, we report on eradication therapy of Helicobacter pylori in the remnant stomach, comparing the eradication rate with that in unoperated stomachs. We examined gross and histological changes after treatment.

Methods. Forty H. pylori-positive patients after distal gastrectomy were treated with proton pump inhibitor (PPI)-based dual and triple therapies. After eradication, histological changes were classified on the basis of the updated Sydney system.

Results. The eradication rate in the remnant stomach was 70% (14 of 20) after dual therapy and 90% (18 of 20) after triple therapy, using per-protocol analysis, and these rates were comparable to the rates of 70% (186 of 264) and 88% (58 of 66), respectively, in nonsurgery patients. After eradication, three sites in the remnant stomach showed similar histological changes: significant decreases in inflammation and activity scores (P < 0.001) and no significant changes in glandular atrophy and intestinal metaplasia scores.

Conclusion. PPI-based therapy was as effective for H. pylori eradication in the remnant stomach as in the unoperated stomach, and eradication therapy resulted in a significant decrease in inflammatory cell infiltration of the mucosal layer.

Key words Helicobacter pylori Remnant stomach Eradication Triple therapy Sydney system 

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Norio Matsukura
    • 1
  • Takashi Tajiri
    • 1
  • Shunji Kato
    • 1
  • Akiyoshi Togashi
    • 1
  • Gotaro Masuda
    • 1
  • Itsuo Fujita
    • 1
  • Akira Tokunaga
    • 1
  • Nobutaka Yamada
    • 2
  1. 1.Surgery for Organ Function and Biological Regulation (First Department of Surgery), Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanJP
  2. 2.Second Department of Pathology, Nippon Medical School, Tokyo, JapanJP

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