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Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes

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Abstract

Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nanoparticles, preparing ultrasmall sized (< 6 nm) particles with precisely-defined structures has remained a grand challenge. In this work, we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes (POSS)-based polyphenol nanoparticles (T8-, T10-, and T12-GAPOSS) by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael “click” reactions. Those polyphenol nanoparticles exhibited strong free radical scavenging capacity, good biocompatibility and ability to resist cell oxidative damage, which demonstrated great potentials in inhibiting oxidative stress induced pathologies.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos. 51603133 and 21774079), National Key R&D Program of China (No. 2019YFA0904500), the Program of the Science, Technology Department of Guangzhou, China (No. 201803020039), and the Fundamental Research Funds for Central Universities.

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Authors and Affiliations

  1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China

    Zhan Li, Haotian Li, Jianhua Zhang, Zhipeng Gu & Yiwen Li

  2. School of Materials Science and Engineering, Xihua University, Chengdu, 610039, China

    Jianhua Zhang

  3. National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou, 450002, China

    Xianhu Liu

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  1. Zhan Li
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  2. Haotian Li
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  3. Jianhua Zhang
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  4. Xianhu Liu
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  5. Zhipeng Gu
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Correspondence to Zhipeng Gu or Yiwen Li.

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Li, Z., Li, H., Zhang, J. et al. Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes. Chin J Polym Sci 38, 1149–1156 (2020). https://doi.org/10.1007/s10118-020-2486-7

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  • DOI: https://doi.org/10.1007/s10118-020-2486-7

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